Results 171 to 180 of about 2,254,091 (312)

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Knowledge, Attitudes, Practices and Education Needs of Dentists on Domestic Violence: A Systematic Review. [PDF]

J Eval Clin Pract
Puello SDCP, Gomes VR, Gondinho BVC, Octaviani JV, Aparici EZ, Guerra LM.   +5 more
europepmc   +1 more source

Violences coloniales, violences impériales

Calenda, 2013
Ce séminaire a pour objet la violence dans les empires coloniaux contemporains. Elle permet d’approcher le phénomène colonial par le biais des pratiques plutôt que des systèmes. En mettant le colonisateur aux prises avec son idée de la civilisation et de la barbarie, elle suscite ou inquiète les discours de légitimation de la domination coloniale.
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Examining the Effectiveness of Typologies of Violence Used in Predicting and Responding to Workplace Violence Against Nurses: A Rapid Review. [PDF]

Int J Nurs Pract
McGregor JR, Ung J, Roffee J, Long K.
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Multilevel correlates of childhood violence in refugee settings: findings from the Ethiopia humanitarian violence against children and youth survey. [PDF]

Glob Health Action
Dessie Y, Wandera B, Odwe G, Obare F, Habteyesus D, Muthuri S, Seruwagi G, Namarra U, Nur A, Kisaakye P, Kabiru CW, Undie CC, Wado YD.   +12 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Non-accidental violence toward sport officials: a scoping review. [PDF]

Front Sports Act Living
Pereira Vargas MLF, Webb T, Gorczynski P, O'Keefe LK, Hancock D.   +4 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source