Results 61 to 70 of about 8,731,984 (297)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

A Matter of Miscommunication: Young People’s Understandings of Rape, Sex and What Lies In-between

Young
Research shows a high prevalence of sexual violations among young people despite widespread agreement on the importance of consent. To understand their perspectives, we conducted focus-group interviews with 63 young Norwegians (aged 16–20) discussing a ...
Hannah Helseth, Carolina Överlien
doaj   +1 more source

Pre-Service Perspectives on E-Teaching: Assessing E-Teaching Using the EPEC Hierarchy of Conditions for E-Learning/Teaching Competence

Canadian Journal of Learning and Technology, 2015
This article examines pre-service teacher perspectives of teaching with an online synchronous (live-time) platform as a part of their training. Fifty-three students who participated in a blended learning (including both face-to-face and online lectures ...
Ashley Sisco, Stuart Woodcock, Michelle Eady   +2 more
doaj   +1 more source

Global and regional estimates of violence against women [PDF]

, 2013
The report presents a global systematic review of scientific data on the prevalence of two forms of violence against women: violence by an intimate partner (intimate partner violence) and sexual violence by someone other than a partner (non-partner ...
Claudia Garcia-Moreno, Christina Pallitto   +1 more
core  

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Development of an Index to Evaluate Children’s Risk for Being Instrumentalized in Intimate Partner Violence against Women Contexts

European Journal of Psychology Applied to Legal Context
Background/Objective: The risk of children being instrumentalized in contexts of gender violence poses a social and health problem that impacts children’s future development.
José C. Ríos Lechuga, Juan M. Alarcón Cuenca, Esther Lopez-Zafra   +2 more
doaj   +1 more source

Outcomes of image-based sexual abuse among young people: a systematic review

Frontiers in Psychology
Image-Based Sexual Abuse (IBSA) is an increasingly recognized issue, especially among young people, yet empirical research on its consequences remains relatively scarce.
Per Moum Hellevik, Linn-Eirin Aronsen Haugen, Carolina Överlien, Carolina Överlien   +3 more
doaj   +1 more source

Epidemiological profile of violence against women in a city in the interior of Maranhão, Brazil

O Mundo da Saúde, 2021
Violence against women at any time in their lives is a serious social and public health problem to be faced in Brazil. In this perspective, the present study aims to analyze the epidemiological profile of female victims of domestic violence in a city in ...
Samylla Bruna de Jesus Silva, Hayla Nunes da Conceição, Marília Ramalho Oliveira, Joseneide Teixeira Câmara, Leônidas Reis Pinheiro Moura, Karoline dos Santos Silva, Beatriz Mourão Pereira   +6 more
doaj  

The national plan to reduce violence against women and their children 2010 – 2022 [PDF]

, 2011
Released in 2011, this 12-year national plan was an COAG initiative supported by Commonwealth, state and territory governments working with the community and includeds the first three-year action plan. Over 12 years the National Plan
Council of Australian Governments
core  

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source