Results 41 to 50 of about 66,998 (219)

A Matter of Miscommunication: Young People’s Understandings of Rape, Sex and What Lies In-between

Young
Research shows a high prevalence of sexual violations among young people despite widespread agreement on the importance of consent. To understand their perspectives, we conducted focus-group interviews with 63 young Norwegians (aged 16–20) discussing a ...
Hannah Helseth, Carolina Överlien
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Development of an Index to Evaluate Children’s Risk for Being Instrumentalized in Intimate Partner Violence against Women Contexts

European Journal of Psychology Applied to Legal Context
Background/Objective: The risk of children being instrumentalized in contexts of gender violence poses a social and health problem that impacts children’s future development.
José C. Ríos Lechuga, Juan M. Alarcón Cuenca, Esther Lopez-Zafra   +2 more
doaj   +1 more source

Outcomes of image-based sexual abuse among young people: a systematic review

Frontiers in Psychology
Image-Based Sexual Abuse (IBSA) is an increasingly recognized issue, especially among young people, yet empirical research on its consequences remains relatively scarce.
Per Moum Hellevik, Linn-Eirin Aronsen Haugen, Carolina Överlien, Carolina Överlien   +3 more
doaj   +1 more source

Epidemiological profile of violence against women in a city in the interior of Maranhão, Brazil

O Mundo da Saúde, 2021
Violence against women at any time in their lives is a serious social and public health problem to be faced in Brazil. In this perspective, the present study aims to analyze the epidemiological profile of female victims of domestic violence in a city in ...
Samylla Bruna de Jesus Silva, Hayla Nunes da Conceição, Marília Ramalho Oliveira, Joseneide Teixeira Câmara, Leônidas Reis Pinheiro Moura, Karoline dos Santos Silva, Beatriz Mourão Pereira   +6 more
doaj  

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Silent Crime : Suatu Ulasan Tentang Kekerasan Terhadap Perempuan 

Veritas: Jurnal Teologi dan Pelayanan, 2010
Beberapa waktu lalu, masyarakat Indonesia dikagetkan dengan sebuah berita: “Manohara Odelia Pinot kabur dari suaminya” yang adalah anggota kesultanan Kelantan, Malaysia pada 31 Mei 2009.
Aileen P. Mamahit,
doaj   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source