Results 161 to 170 of about 92,388 (260)

Targeting notch signaling to restore neural development and behavior in mouse models of ASD. [PDF]

Nat Commun
Hanno Y, Nakanishi M, Takase A, Nomura J, Tanaka M, Iida Y, Tanaka M, Hosokawa H, Ito M, Mikami K, Hozumi K, Miyoshi G, Takumi T, Iijima T.   +13 more
europepmc   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Bioactivity-guided metabolomics reveals discriminant cytotoxic signatures in Siparuna guianensis. [PDF]

Metabolomics
Asghar S, Bevilaqua GB, Guarneire GJ, Ludgero SCC, Castro SBR, Carli AP, Alves CCS, Gontijo B, Dias DF, Soares MG, Lima NM.   +10 more
europepmc   +1 more source

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

Multi-stable oscillations in cortical networks with two classes of inhibition. [PDF]

PLoS Comput Biol
Dey Sarkar A, Ermentrout B.
europepmc   +1 more source

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

Tail-Suspension Model of Simulated Microgravity-Induced Functional Dyspepsia in Rats: Behavioral, Motility, and Brain-Gut Peptide Alterations. [PDF]

Int J Mol Sci
Li W, Li Y, Wang F, Qi H, Fan B, Wang G, Wang Q.   +6 more
europepmc   +1 more source

Gut Microbiota of Gray Snub‐Nosed Monkeys: Adaptation to Seasonal Variations Through Energy Compensation and Thermogenesis

Integrative Zoology, EarlyView.
Based on metagenome‐assembled genomes (MAGs), the gut microbiota of the gray snub‐nosed monkeys recovered 1229 non‐redundant MAGs. The gut microbiota showed an enhanced capacity to produce energy substrates with increased conversion activity of these substrates during winter.
Yue Sun, Mingyi Zhang, Xiaochen Wang, Xiaolong Huang, Yanze Yu, Huijuan Pan, Haibo Li, Lei Shi, Wei Yang, Chen Zhang, Bo Ding, Xun Liu, Jianfeng Li, Changjiang Qian, Boxing Cheng, Chao Zhang, Jingcheng Ran, Ming Li   +17 more
wiley   +1 more source

Metabolomic study of Cynara cardunculus L. growing at different altitudes reveals the flowering stage as the balsamic time. [PDF]

BMC Plant Biol
Mandrone M, Chiocchio I, Trincia S, De Agostini A, Sanna C, Poli F.   +5 more
europepmc   +1 more source

Adapting to Urban Heights: Multidimensional Gradients Drive Nest‐Selection Plasticity and Trade‐Offs in a Human‐Commensal Sparrow

Integrative Zoology, EarlyView.
Urban Eurasian tree sparrows exhibit pronounced nest‐site plasticity, exploiting vertical building space while preferring lower nest heights when sites are abundant. Nest decisions are driven by altitude and building height rather than other factors, indicating a shift toward anthropogenic resources in cities.
Yang Wang, Guanqun Kou, Fangyuan Liu, Xu Liu, Juyong Li, Jie Wang, Qian Zhang, Yuan Yin, Limin Wang, John C. Wingfield, Fumin Lei, Dongming Li   +11 more
wiley   +1 more source