Results 251 to 260 of about 273,852 (324)

Local government social care workforce development expenditure: a survey of trends and funding. [PDF]

, 2008
Bates, Natalie, Brown, Keith, Keen, Steven   +2 more
core  

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Associations of Candidate Gene Polymorphisms with Egg Production and Egg Quality Traits in Atak-S Laying Hens. [PDF]

Int J Mol Sci
Ilhan F, Aygun A.
europepmc   +1 more source

Tinkering Towards Sustainability: Bundling Innovations to Electrify the Fossil‐Dependent Process Industry

Creativity and Innovation Management, EarlyView.
ABSTRACT Sustainability transitions, such as electrifying the process industry, require a bundle of related innovations to make meaningful progress. Drawing on literature on innovation through tinkering, that is, adaptive, typically small‐scale experimentation with various forms of innovation, and applying a micropolitical perspective, this qualitative
Karin Wigger, Anna Yström, Alexander Gorgijevski, Viktor Werner   +3 more
wiley   +1 more source

Metabolomics Reveals Glyoxylate and Dicarboxylate Metabolism Disorder in Elderly Trauma: A Retrospective Study. [PDF]

Clin Interv Aging
Huang C, Gou Y, Cong Y, Li D, Yang J, Feng K.   +5 more
europepmc   +1 more source

PIK‐III‐Mediated Elevation of Thiamine Re‐Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1

Cell Proliferation, EarlyView.
PIK‐III enhancing the efficacy of cuproptosis to kill renal cancer cells through dysregulating thiamine metabolism and dephosphorylation of pyruvate dehydrogenase complex E1 (PDHA1), providing a potential option for treatment of cuproptosis‐resistant renal cancer by the combination of PIK‐III and elesclomol.
Dongdong Xie, Yu Wang, Wenjie Cheng, Minbo Yan, Kunyu Li, Xiang Wu, Jiaqing Wu, Zhuangzhuang Zhang, Yingbo Dai   +8 more
wiley   +1 more source

Altered Sigmoid Mucosal Innervation and Mast Cell Proximity to Sensory Nerve Fibers Are Associated With Symptom Severity in Patients With Irritable Bowel Syndrome. [PDF]

Neurogastroenterol Motil
Yuan PQ, Nash M, Li T, Mahurkar-Joshi S, Sohn J, Khandadash A, Taché Y, Chang L.   +7 more
europepmc   +1 more source

LPC18:0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55‐Mediated Signalling in Spinal Cord Injury

Cell Proliferation, EarlyView.
LPC18:0 secreted by exogenous neural stem cells potentiates neurogenesis via the GPR55/AKT/GSK3β signalling axis, which ultimately promotes spinal cord injury recovery. ABSTRACT Spinal cord injury (SCI) is a devastating condition with limited therapeutic options. Although neural stem cell (NSC) transplantation shows regenerative potential, its efficacy
Dong Chen, Shuo Liu, Le‐Yi Tu, Ming‐Mei Yang, Cong‐Wang Xu, Yue Jiang, Hui Yang, Chen‐Xu Tai, Yan‐Ning Wang, Yuan‐Yuan Xie, Ping‐Ping Shen, Bin Wang   +11 more
wiley   +1 more source

VIP syndrome in surgical oncology: ethical and clinical challenges in resource-limited settings. [PDF]

Oncol Rev
Ray M, Kottu HS.
europepmc   +1 more source

SAFE SPACES AND FREE SPEECH ON CAMPUS: A GUIDED TOUR OF CAMPUS CONTEXTS

Educational Theory, EarlyView.
Abstract Contemporary events on university campuses have spotlighted the perceived conflict between free speech and safe spaces. While both values are widely acknowledged as essential, reconciling them in practice remains difficult. In this article, we argue that universities should not be viewed as singular entities but as a constellation of distinct ...
Bryan R. Warnick, Jamie Herman, Kyle Williams   +2 more
wiley   +1 more source