Results 81 to 90 of about 2,913,940 (309)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

A Transparency Standard for Derivatives [PDF]

open access: yes
Derivatives exposures across large financial institutions often contribute to – if not necessarily create – systemic risk. Current reporting standards for derivatives exposures are nevertheless inadequate for assessing these systemic risk contributions ...
Viral V. Acharya
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The interplay between viral-derived miRNAs and host immunity during infection [PDF]

open access: yes, 2019
MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene expression during cellular processes. The host-encoded miRNAs are known to modulate the antiviral defense during viral infection.
Ingle, Harshad   +3 more
core   +1 more source

Investigating the generalizability of EEG-based Cognitive Load Estimation Across Visualizations

open access: yes, 2018
We examine if EEG-based cognitive load (CL) estimation is generalizable across the character, spatial pattern, bar graph and pie chart-based visualizations for the nback~task.
Bilalpur, Maneesh   +5 more
core   +1 more source

Leverage, Moral Hazard and Liquidity [PDF]

open access: yes, 2010
We consider a moral hazard setup wherein leveraged firms have incentives to take on excessive risks and are thus rationed when they attempt to roll over debt. Firms can sell assets to alleviate rationing.
Acharya, Viral, Viswanathan, S.
core   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Respiratory Viral Coinfections: Insights into Epidemiology, Immune Response, Pathology, and Clinical Outcomes

open access: yesPathogens
Respiratory viral coinfections are a global public health threat that poses an economic burden on individuals, families, and healthcare infrastructure.
Pius I. Babawale   +1 more
doaj   +1 more source

Are banks passive liquidity backstops? deposit rates and flows during the 2007-2009 crisis [PDF]

open access: yes
Can banks maintain their advantage as liquidity providers when they are heavily exposed to a financial crisis? The standard argument - that banks can - hinges on deposit inflows that are seeking a safe haven and provide banks with a natural hedge to fund
Nada Mora, Viral V. Acharya
core  

Correction for founder effects in host-viral association studies via principal components [PDF]

open access: yes, 2012
Viruses such as HIV and Hepatitis C (HCV) replicate rapidly and with high transcription error rates, which may facilitate their escape from immune detection through the encoding of mutations at key positions within human leukocyte antigen (HLA)-specific ...
James, I.R.   +2 more
core   +2 more sources

Home - About - Disclaimer - Privacy