Results 71 to 80 of about 2,275,769 (309)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
2020 National viral hepatitis progress report [PDF]
The National Viral Hepatitis Progress Report provides information on ten data indicators, providing an objective way to assess progress toward achieving key viral hepatitis goals.Publication date from document properties.NationalProgressReport2020 ...
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Activation of the interferon induction cascade by influenza A viruses requires viral RNA synthesis and nuclear export [PDF]
, 2014 This work is supported by grants from the Wellcome Trust (grants 087751/A/08/Z) and MRC (G1001726/1).We have examined the requirements for virus transcription and replication and thus the roles of input and progeny genomes in the generation of interferon
Randall, Richard E +3 more
core +1 more source
PathogensRespiratory viral coinfections are a global public health threat that poses an economic burden on individuals, families, and healthcare infrastructure.
Pius I. Babawale +1 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
2021 National viral hepatitis progress report [PDF]
The National Viral Hepatitis Progress Report provides information on ten data indicators, providing an objective way to assess progress toward achieving key viral hepatitis goals.Publication date from document properties.FactSheet ...
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Fast Facts:\ue2\u20ac\ua2 People with HIV infection are affected disproportionally by viral hepatitis.\ue2\u20ac\ua2 Nearly 75% of people with HIV who report a history of injection drug use also are infected with hepatitis C virus (HCV).\ue2\u20ac\ua2 ...
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Division of Viral Hepatitis 2025 strategic plan [PDF]
DVH\u2019s 2025 Strategic Plan articulates DVH\u2019s vision, mission, core values, and goals. Each goal is further defined by specific and time-bound outcome measures and supporting objectives and associated strategies.
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