Results 81 to 90 of about 1,330,033 (311)

Development and biological activity of long-acting recombinant human interferon-α2b

BMC Biotechnology, 2020
Background The type I human interferon (IFN) family consists of a group of cytokines with a multiplicity of biological activities, including antiviral, antitumor, and immunomodulatory effects.
Qian Zhang, Chao Wang, Fenlian Ma, Lihong Yao, Hanchun Gao, Luyan Zhu, Lishu Zheng   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Endogenous Viral Etiology of Prion Diseases

, 2009
Transmissible spongiform encephalopathies (TSEs), or prion diseases, are a group of incurable neurodegenerative disorders, including Kuru and Creutzfeldt-Jakob disease in humans, “mad cow” disease in cattle, and scrapie in sheep. This paper
Claudiu I. Bandea
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Synonymous substitution rates predict HIV disease progression as a result of underlying replication dynamics

, 2007
Upon HIV transmission, some patients develop AIDS in only a few months, while others remain disease free for 20 or more years. This variation in the rate of disease progression is poorly understood and has been attributed to host genetics, host immune ...
Pybus, OG, Drummond Alexei J, Lemey, P, Drummond, AJ, Kosakovsky Pond, Sergei L., Shapiro, B, Alexei J. Drummond, Pond, Sergei L. Kosakovsky|, Shapiro Beth, Helena Barroso, Kosakovsky Pond Sergei L, Pybus Oliver G, Beth Shapiro, Rambaut, A, Barroso, H, Philippe Lemey, Shapiro, Beth, Sergei L Kosakovsky Pond, Alexei J Drummond, Nuno Taveira, Rambaut Andrew, Drummond, Alexei J., Rambaut, Andrew, Kosakovsky Pond, SL, Pybus, Oliver G., Lemey Philippe, Andrew Rambaut, Lemey, Philippe, Barroso, Helena, Sergei L. Kosakovsky Pond, Oliver G. Pybus, Taveira Nuno, Oliver G Pybus, Barroso Helena, Pond, Sergei L. Kosakovsky, Taveira, N, Pond, SLK, Taveira, Nuno   +37 more
core   +1 more source

Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation [PDF]

, 2010
End-stage liver disease caused by chronic hepatitis C virus (HCV) infection is a leading cause for liver transplantation (LT). Due to viral evasion from host immune responses and the absence of preventive antiviral strategies, reinfection of the graft is
Pessaux, Patrick, Doffoel, Michel, Leroux-Roels, G., Stoll-Keller, Françoise, Michel Doffoël, Patel, Arvind H, Samira Fafi-Kremer, Fofana, I., Soulier, E., Patric Carolla, Fafi-Kremer, S., Doffoel, M., Stoll-Keller, F., Cosset, F.-L., Meuleman, Philip, Fafi-Kremer, Samira, Eric Soulier, Philip Meuleman, Isabel Fofana, Wolf, P., Soulier, Eric, Cosset, François-Loic, François-Loïc Cosset, Leroux-Roels, Geert, Wolf, Philippe, Françoise Stoll-Keller, Philippe Wolf, Carolla, Patric, Pessaux, P., Meuleman, P., Baumert, Thomas F, Patel, A.H., Fofana, Isabel, Patrick Pessaux, Thomas F. Baumert, Arvind H. Patel, Geert Leroux-Roels, Carolla, P., Baumert, T.F.   +38 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Surveillance, epidemiology, and pathogen spectrum of hand, foot, and mouth disease in mainland of China from 2008 to 2017

Biosafety and Health, 2019
Hand, foot and mouth disease (HFMD) was reported in May 2, 2008 to be the 38th legally notifiable disease in China's National Notifiable Disease Reporting and Surveillance System.
Tianjiao Ji, Taoli Han, Xiaojuan Tan, Shuangli Zhu, Dongmei Yan, Qian Yang, Yang Song, Aili Cui, Yan Zhang, Naiying Mao, Songtao Xu, Zhen Zhu, Dandan Niu, Yong Zhang, Wenbo Xu   +14 more
doaj   +1 more source

Unravelling the structure of viral replication complexes at super-resolution [PDF]

, 2013
This work was supported by Biotechnology and Biomedical Sciences Research Council grant BB/H018719/1During infection, many RNA viruses produce characteristic inclusion bodies that contain both viral and host components.
Karl J. Oparka, Tilsner, Jens, Jens eTilsner, Johannes Liesche, Johannes eLiesche, Olga Linnik, Liesche, Johannes, Olga eLinnik, Karl eOparka, Oparka, Karl J, Jens Tilsner, Oparka, Karl J., Linnik, Olga   +12 more
core   +1 more source