Results 61 to 70 of about 6,506,858 (262)

Stimulation requirement and pathogenetic significance of T cells during chronic viral hepatitis. [PDF]

, 2007
Hepatitis B virus (HBV) and Hepatitis C virus (HCV) are important causes of liver inflammation and fibrosis. More than 500 million people are persistently infected worldwide and consequently are at increased risk of developing chronic liver disease ...
Kennedy, P.
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Meta-analysis of gene expression profiles in long-term non-progressors infected with HIV-1

BMC Medical Genomics, 2019
Background In the absence of antiretroviral treatments (ARTs), a small group of individuals infected with HIV, including long-term non-progressors (LTNPs) who maintain high levels of CD4+ T cells for more than 7–10 years in the absence of ART and in ...
Sun Young Lee, Yong Kwang Park, Cheol-Hee Yoon, Kisoon Kim, Kyung-Chang Kim   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Disease progression in Human Immunodeficiency Virus type 1 infected viraemic controllers [PDF]

, 2012
PhDBackground: The mechanism of CD4+ T-cell decline in Human Immunodeficiency Virus-1 (HIV-1) infection is unclear, but the association with plasma HIV-1 RNA-load suggests viral replication is involved.
Groves, Katherine Claire
core   +4 more sources

Viral hepatitis surveillance United States, 2018 [PDF]

Viral Hepatitis Surveillance \u2014 United States, 2018 is published by the Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC), U.S.

core   +2 more sources

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The state of biosafety across China's CDC microbiology laboratories: insights from a nationwide survey (2021–2023)

Frontiers in Public Health
BackgroundThe COVID-19 pandemic underscored the critical importance of biosafety in microbiology laboratories worldwide. In response, China has ramped up its efforts to enhance biosafety measures within its Centers for Disease Control and Prevention (CDC)
Peihua Niu, Zhenlu Sun, Ruiqing Zhang, Yiming Zhao, Fengyu Tian, Ping Cheng, Hongmei Zheng, Jianqiang Guo, Meng Zhang, Xuejun Ma, Ji Wang   +10 more
doaj   +1 more source

Synonymous substitution rates predict HIV disease progression as a result of underlying replication dynamics [PDF]

, 2007
Upon HIV transmission, some patients develop AIDS in only a few months, while others remain disease free for 20 or more years. This variation in the rate of disease progression is poorly understood and has been attributed to host genetics, host immune ...
Pybus, OG, Drummond Alexei J, Lemey, P, Drummond, AJ, Kosakovsky Pond, Sergei L., Shapiro, B, Alexei J. Drummond, Pond, Sergei L. Kosakovsky|, Shapiro Beth, Helena Barroso, Kosakovsky Pond Sergei L, Pybus Oliver G, Beth Shapiro, Rambaut, A, Barroso, H, Philippe Lemey, Shapiro, Beth, Sergei L Kosakovsky Pond, Alexei J Drummond, Nuno Taveira, Rambaut Andrew, Drummond, Alexei J., Rambaut, Andrew, Kosakovsky Pond, SL, Pybus, Oliver G., Lemey Philippe, Andrew Rambaut, Lemey, Philippe, Barroso, Helena, Sergei L. Kosakovsky Pond, Oliver G. Pybus, Taveira Nuno, Oliver G Pybus, Barroso Helena, Pond, Sergei L. Kosakovsky, Taveira, N, Pond, SLK, Taveira, Nuno   +37 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source