Results 51 to 60 of about 6,506,858 (262)

CD25(+) Natural Regulatory T Cells Are Critical in Limiting Innate and Adaptive Immunity and Resolving Disease following Respiratory Syncytial Virus Infection [PDF]

, 2010
Regulatory CD4(+) T cells have been shown to be important in limiting immune responses, but their role in respiratory viral infections has received little attention.
Harker, JA, Johansson, C, Cecilia Johansson, Tregoning, John S, Jürgen Schwarze, Atabani, Sowsan F, Lee, Debbie C P, Atabani, SF, Lee, DC, Harker, James A E, Peter J. M. Openshaw, Schwarze, J, Harker, JAE, James A. E. Harker, Openshaw, Peter J M, Tregoning, JS, Lee, DCP, Johansson, Cecilia, John S. Tregoning, Openshaw, PJ, Schwarze, Jürgen, Openshaw, PJM, Debbie C. P. Lee, Sowsan F. Atabani   +23 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Correction: Guo et al. A Mixture of T-Cell Epitope Peptides Derived from Human Respiratory Syncytial Virus F Protein Conferred Protection in DR1-TCR Tg Mice. Vaccines 2024, 12, 77

Vaccines
The authors would like to make the following corrections to this published paper [...]
Hong Guo, Yang Song, Hai Li, Hongqiao Hu, Yuqing Shi, Jie Jiang, Jinyuan Guo, Lei Cao, Naiying Mao, Yan Zhang   +9 more
doaj   +1 more source

Reduction in morbidity and mortality from childhood diarrhoeal disease after species A rotavirus vaccine introduction in Latin America : a review

Memorias do Instituto Oswaldo Cruz, 2011
Countries in Latin America were among the first to implement routine vaccination against species A rotavirus (RVA). We evaluate data from Latin America on reductions in gastroenteritis and RVA disease burden following the introduction of RVA vaccine ...
Rishi Desai, Lucia Helena de Oliveira, Umesh D Parashar, Benjamin Lopman, Jacqueline E Tate, Manish M Patel   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A rapid and sensitive recombinase aided amplification assay to detect hepatitis B virus without DNA extraction

BMC Infectious Diseases, 2019
Background Hepatitis B virus (HBV) infection is the major public health problem worldwide. In clinical practice, serological and molecular assays are the most commonly used diagnostic methods to detect HBV infection in clinical practices. Methods Here we
Xin-xin Shen, Fang-zhou Qiu, Li-Ping Shen, Ten-fei Yan, Meng-chuan Zhao, Ju-Ju Qi, Chen Chen, Li Zhao, Le Wang, Zhi-shan Feng, Xue-jun Ma   +10 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease [PDF]

, 2012
Hepatitis B virus (HBV)-specific T-cell responses are important in the natural history of HBV infection. The number of known HBV-specific T-cell epitopes is limited, and it is not clear whether viral evolution occurs in chronic HBV infection. We aimed to
Chopra, A., Gordon, A, Scott Bowden, Pfafferott, K, Desmond, P.V., Ian R. James, Revill, P.A., Chopra, A, Mallal, SA, Silvana Gaudieri, Anna Ayres, Lewin, S.R., Thompson, AJ, Desmond, C.P., Jennifer Audsley, James, IR, Locarnini, SA, Stephen A. Locarnini, Sharon R. Lewin, James, I.R., Locarnini, S.A., Chivers, S., Christopher P. Desmond, Desmond, PV, Thompson, A.J., Stuart K. Roberts, Audsley, J, Revill, PA, Lau, GK, Gaudieri, S, Gaudieri, S., Audsley, J., Day, C, Caroline Day, Ayres, A, Day, C., Paul V. Desmond, Pfafferott, K., Gordon, A., Roberts, SK, Peter A. Revill, Alexander J. Thompson, Ayres, A., Desmond, CP, Sarah Chivers, Katja Pfafferott, Bowden, S., George K. Lau, Simon A. Mallal, Lewinb, SR, Lau, G.K., Roberts, S. K., Abha Chopra, Bowden, S, Mallal, S.A., Adam Gordon, Chivers, S   +56 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Epidemiological characteristics of seven notifiable respiratory infectious diseases in the mainland of China: an analysis of national surveillance data from 2017 to 2021

Infectious Diseases of Poverty, 2023
Background Respiratory infectious diseases (RIDs) remain a pressing public health concern, posing a significant threat to the well-being and lives of individuals.
Le-le Deng, Ya-jun Han, Zhuo-wei Li, Da-yan Wang, Tao Chen, Xiang Ren, Guang-xue He   +6 more
doaj   +1 more source