Results 1 to 10 of about 4,114,474 (307)

Sp100 Provides Intrinsic Immunity against Human Papillomavirus Infection

mBio, 2013
Most DNA viruses associate with, and reorganize, nuclear domain 10 (ND10) bodies upon entry into the host nucleus. In this study, we examine the roles of the ND10 components PML, Sp100, and Daxx in the establishment of human papillomavirus type 18 (HPV18)
Wesley H. Stepp, Jordan M. Meyers, Alison A. McBride   +2 more
doaj   +1 more source

Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance

mBio, 2019
Flaviviruses are controlled by adaptive immune responses but are exquisitely sensitive to interferon-stimulated genes (ISGs). How coinfections, particularly simian immunodeficiency viruses (SIVs), that induce robust ISG signatures influence flavivirus ...
Carol L. Vinton, Samuel J. Magaziner, Kimberly A. Dowd, Shelly J. Robertson, Emerito Amaro-Carambot, Erik P. Karmele, Alexandra M. Ortiz, Carly E. Starke, Joseph C. Mudd, Stephen S. Whitehead, Sonja M. Best, Theodore C. Pierson, Heather D. Hickman, Jason M. Brenchley   +13 more
doaj   +1 more source

Real-time tracking of vaccinia virus entry using a split luciferase complementation assay

Journal of Virology
A recombinant vaccinia virus (vA4-HiBiT) was constructed with a short, split luciferase HiBiT tag at the C-terminus of the A4 core protein open reading frame.
Yunliang Zhang, Jaroslav Holly, James Gibbs, Jonathan W. Yewdell, Bernard Moss   +4 more
doaj   +1 more source

25-Hydroxycholesterol restricts human norovirus replication in human intestinal enteroids

Journal of Virology
Norovirus is the leading cause of acute gastroenteritis worldwide. Since the development of human intestinal enteroid (HIE) cell culture systems, significant advancements have been made in exploring and evaluating therapeutic strategies to combat human ...
Verónica Costantini, Wadzanai P. Mboko, Helen Wall, Kimberly Huynh, Anna M. Montmayeur, Geun Woo Park, Ruijie Xu, Jan Vinjé, Preeti Chhabra   +8 more
doaj   +1 more source

Efficacy of modified-vaccinia Ankara vaccine as pre- and post-exposure prophylaxis against monkeypox sexual transmission in non-human primate model

Nature Communications
The monkeypox virus (MPXV) outbreak of 2022 caused a human disease with unusual epidemiological and clinical features, notably an increase in human-to-human transmission through sexual contact, predominantly among men who have sex with men (MSM).
Cécile Herate, Audrey Ferrier-Rembert, Francis Relouzat, Anne-Sophie Gallouët, Quentin Pascal, Hélène Letscher, Mariangela Cavarelli, Nathalie Dereuddre-Bosquet, Wesley Gros, Benoit Delache, Sébastien Langlois, Hawa Timera, Fanny Jarjaval, Laetitia Bossevot, Camille Ludot, Catherine Brua, Maxence Lechemia, Olivier Ferraris, Nathalie Silvestre, Roger Le Grand, Jean-Nicolas Tournier   +20 more
doaj   +1 more source

Early Generation of New PrPSc on Blood Vessels after Brain Microinjection of Scrapie in Mice

mBio, 2015
Aggregation of misfolded host proteins in the central nervous system is believed to be important in the pathogenic process in several neurodegenerative diseases of humans, including prion diseases, Alzheimer's disease, and Parkinson's disease.
Bruce Chesebro, James Striebel, Alejandra Rangel, Katie Phillips, Andrew Hughson, Byron Caughey, Brent Race   +6 more
doaj   +1 more source

Functional Characterization of Circulating Mumps Viruses with Stop Codon Mutations in the Small Hydrophobic Protein

mSphere, 2020
Between 2015 and 2017, routine molecular surveillance in the United States detected multiple mumps viruses (MuVs) with mutations in the small hydrophobic (SH) gene compared to a reference virus of the same genotype.
Rita Czakó Stinnett, Andrew S. Beck, Elena N. Lopareva, Rebecca J. McNall, Donald R. Latner, Carole J. Hickman, Paul A. Rota, Bettina Bankamp   +7 more
doaj   +1 more source

Switching to bictegravir/emtricitabine/tenofovir alafenamide from efavirenz/emtricitabine/tenofovir disoproxil in virologically suppressed people with HIV: findings from a non-randomized clinical trial (EBONY study)

International Journal of Infectious Diseases
Objectives: No previous studies specifically explored the switch from efavirenz to bictegravir (BIC)-containing three-drug antiretroviral regimens.
Roberta Gagliardini, Marta Camici, Simone Lanini, Rita Bellagamba, Sandrine Ottou, Maria Maddalena Plazzi, Alessandra Vergori, Valentina Mazzotta, Annalisa Mondi, Marisa Fusto, Jessica Paulicelli, Massimo Tempestilli, Carmela Pinnetti, Elisabetta Grilli, Ilaria Mastrorosa, Federico De Zottis, Giulia Del Duca, Andrea Antinori   +17 more
doaj   +1 more source

The control of diarrhea, the case of a rotavirus vaccine

Salud Pública de México, 2019
[Not available]
Umesh D Parashar, Jacqueline E Tate
doaj   +1 more source

Adaptive mutations of neuraminidase stalk truncation and deglycosylation confer enhanced pathogenicity of influenza A viruses

Scientific Reports, 2017
It has been noticed that neuraminidase (NA) stalk truncation has arisen from evolutionary adaptation of avian influenza A viruses (IAVs) from wild aquatic birds to domestic poultry.
Sehee Park, Jin Il Kim, Ilseob Lee, Joon-Yong Bae, Kirim Yoo, Misun Nam, Juwon Kim, Mee Sook Park, Ki-Joon Song, Jin-Won Song, Sun-Ho Kee, Man-Seong Park   +11 more
doaj   +1 more source