Results 91 to 100 of about 911,253 (363)

A Transcriptome‐Wide Mendelian Randomization Study in Isolated Human Immune Cells Highlights Risk Genes Involved in Viral Infections and Potential Drug Repurposing Opportunities for Schizophrenia

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Schizophrenia is a neurodevelopmental psychiatric disorder characterized by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (causal, correlated, consequential) and the mechanisms involved are not fully understood.
David Stacey, Liam Gaziano, Preethi Eldi, Catherine Toben, Beben Benyamin, S. Hong Lee, Elina Hyppönen   +6 more
wiley   +1 more source

The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system. [PDF]

, 1992
Following intracerebral inoculation of adult Balb/c Byj mice, the MHV-4 strain of mouse hepatitis virus (MHV) had an LD50 of less than 0.1 PFU, whereas its monoclonal antibody resistant variant V5A13.1 had an LD50 of 10(4.2) PFU.
Bloom, F, Buchmeier, MJ, Fazakerley, JK, Parker, SE   +3 more
core   +1 more source

Arbovirus and seizures

Acta Epileptologica, 2020
The high prevalence and spread of arthropod-borne viruses (arboviruses) make them an important cause of viral encephalitis in humans. Most epidemic viral encephalitides have an etiology associated with arboviruses. Among various arboviruses, the Japanese
Mingrui Zheng, Shichuo Li, R. Edward Hogan, Meihua Yang   +3 more
doaj   +1 more source

A case report of anti-NMDA receptor encephalitis in a young Egyptian female patient presenting with hyperreligiosity

The Egyptian Journal of Internal Medicine, 2023
Anti-n-methyl-d-aspartate receptor (NMDAR) encephalitis is a form of autoimmune encephalitis that remains under-recognized due to the variability of the initial symptoms and can be misdiagnosed as viral encephalitis or other pathogens.
Hamdi Ibrahim, Attaa Ali, Safwat Abdel Maksod, Magdy Khorshed, Mona Wassef, Mostafa Alfishawy, Hanan Rady, Adel Mohamed, Mohamed Mahmod, Khaled Ismael, Marwa Haron, Suzan Said, Riham Adel, Noha Mohamed   +13 more
doaj   +1 more source

New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond

Annals of Neurology, EarlyView.
The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, guided by gains in understanding the fundamental immunology, neurobiology, genetics, and triggers of this disease, have broadened the traditional focus on ...
Joseph J. Sabatino Jr., Bruce A. C. Cree, Stephen L. Hauser   +2 more
wiley   +1 more source

The chemokine receptor CXCR2 and coronavirus-induced neurologic disease. [PDF]

, 2013
Inoculation with the neurotropic JHM strain of mouse hepatitis virus (MHV) into the central nervous system (CNS) of susceptible strains of mice results in an acute encephalomyelitis in which virus preferentially replicates within glial cells while ...
Akwa, Bajetto, Bakshi, Barnett, Bauer, Belperio, Bergmann, Bergmann, Bergmann, Bergmann, Boyle, Brett S. Marro, Buchmeier, Burrer, Carbajal, Carlson, Castro, Cervantes-Barragan, Cheever, Chen, Cho, Coughlan, Danik, Dorf, Epstein, Field, Filipovic, Filipovic, Fischer, Fleming, Fleury, Flynn, Frohman, Glabinski, Glaser, Glass, Glass, Glass, Glass, Glass, Goebels, Gonzalez, Gonzalez, Gorio, Hauser, Held, Held, Hiremath, Holmes, Horuk, Hosking, Hosking, Houtman, Ireland, Jason G. Weinger, Juedes, Kapil, Katz-Levy, Kerstetter, Kielian, Kim, Klein, Kroenke, Lane, Lane, Lin, Lin, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Londhe, Londhe, Lu, Malone, Marques, Marsh, Marten, Marten, Marten, Martin, Martin P. Hosking, Masters, Matthews, Matthews, Matute, Mazaleuskaya, McMahon, Merabova, Miller, Minagawa, Moser, Nguyen, Omari, Omari, Omari, Padovani-Claudio, Parra, Parra, Pearce, Perlman, Pewe, Pewe, Phares, Phares, Popivanova, Ramakrishna, Ramakrishna, Ramakrishna, Raman, Rempel, Rempel, Robinson, Roth-Cross, Roth-Cross, Saas, Savarin, Schumacher, Scott, Smith, Stiles, Stiles, Stohlman, Stohlman, Strieter, Sui, Sun, Tarassishin, Templeton, Thomas E. Lane, Tirotta, Tirotta, Tonai, Tran, Traugott, Traugott, Trifilo, Trifilo, Tsai, Tschen, Tuohy, Tuohy, Turbic, Ubogu, van der Hoek, van der Hoek, Versteeg, Walsh, Walsh, Wang, Wareing, Watson, Weiss, Wengner, Wolpe, Woo, Woodroofe, Wu, Wu, Xia, Xue, Yong, Zhang, Zhang, Zhou, Zhou, Zhou, Zhou, Zhou, Zuo   +172 more
core   +1 more source

Towards Differentiation of Viral Encephalitis

Aktualʹnaâ Infektologiâ, 2014
Viral encephalitis is one of the important directions of modern neurology. Practitioners have diagnostic difficulties that require differentiation from neoplastic process, acute cerebral vascular syndromes, toxic encephalopathy, psychosis. In this regard,
T.V. Mironenko, G.A. Pogorelova
doaj   +1 more source

Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy

Annals of Neurology, EarlyView.
Objective To assess the diagnostic accuracy of metabolites in cerebrospinal fluid (CSF) for central nervous system (CNS) infections. Methods Patients were derived from three prospective cohort studies in the Netherlands. All studies included adults suspected of a CNS infection who underwent a diagnostic lumbar puncture.
Steven L. Staal, Sabine E. Olie, Michel van Weeghel, Bauke V. Schomakers, Frédéric M. Vaz, I‐PACE Study Group, Diederik van de Beek, Matthijs C. Brouwer   +7 more
wiley   +1 more source

Clinical perspectives of emerging pathogens in bleeding disorders. [PDF]

, 2006
As a result of immunological and nucleic-acid screening of plasma donations for transfusion-transmissible viruses, and the incorporation of viral reduction processes during plasma fractionation, coagulation-factor concentrates (CFC) are now judged safe ...
Bozzette, Samuel, Diamond, Michael, Koerper, Marion A, Kulkarni, Roshni, Ludlam, Christopher A, Powderly, William G, Ritchie, Bruce, Siegel, Jamie, Simmonds, Peter, Stanley, Samuel, Tapper, Michael L, von Depka, Mario   +11 more
core   +1 more source

RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation [PDF]

, 2017
Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Daniels, Brian P., Gale, Michael, Loo, Yueh-Ming, Martinez, Jennifer, Oberst, Andrew, Oguin III, Thomas H., Olsen, Tayla M., Orozco, Susana, Snyder, Annelise G., Tait, Stephen W.G.   +9 more
core   +1 more source