Results 211 to 220 of about 663,857 (285)

Efficacy and Effectiveness of the Recombinant Zoster Vaccine Against Herpes Zoster, Herpes Zoster Ophthalmicus, Postherpetic Neuralgia and Dementia: A Systematic Review and Meta‐Analysis

open access: yesReviews in Medical Virology, Volume 36, Issue 5, September 2026.
ABSTRACT Herpes zoster (HZ, shingles) constitutes a significant public health concern, particularly in ageing populations, and there is growing global interest in the recombinant zoster vaccine (RZV) from a public health perspective. In this systematic review with meta‐analysis, we assessed the efficacy and effectiveness of RZV against HZ and its ...
E. Heen   +11 more
wiley   +1 more source

Inhibition of mitophagy via the EIF2S1-ATF4-PRKN pathway contributes to viral encephalitis. [PDF]

open access: yesJ Adv Res
Song X   +10 more
europepmc   +1 more source

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

open access: yesChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira   +8 more
wiley   +1 more source

Design and Synthesis of a Potent, Cell Active Purine‐Based Amidoxime Against the Dengue Virus

open access: yesChemistrySelect, Volume 11, Issue 36, 22 September 2026.
Scaffold hopping from our previous indolazepinone hit exemplifies purine SP‐835G with DENV2 EC50 0.1 µM, CC50>100 µM, clogP 3.61. Docking studies support its amidine metabolite operates as an allosteric inhibitor of DENV(pro). A flexible ether linker appears pivotal for enhancing binding and activity.
Dimitrios Kiousis   +8 more
wiley   +1 more source

Molecular and Serological Screening of West Nile and Usutu Virus in Birds and Humans: A Sentinel Study in Finland

open access: yesVeterinary Medicine and Science, Volume 12, Issue 5, September 2026.
We developed sensitive real‐time PCR assays for West Nile virus and Usutu virus to screen bird and human samples in Finland. Although no positive samples were detected, active migratory flyways and recent cases in neighbouring countries highlight the risk of future introduction and the need for continued surveillance.
Ruut Joensuu   +6 more
wiley   +1 more source

Review on Major Challenges of Veterinary Service Delivery in Ethiopia

open access: yesVeterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Ethiopian veterinary services face systemic barriers, including inadequate infrastructure, a severe shortage of qualified veterinarians, and underfunded diagnostic facilities, particularly in rural and pastoralist areas. These challenges, compounded by limited access to molecular diagnostic tools, poor data sharing, and low public awareness, result in ...
Abdu Muhammed, Mitiku Wamile
wiley   +1 more source

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