Results 81 to 90 of about 911,253 (363)

Macaque models of human infectious disease. [PDF]

open access: yes, 2008
Macaques have served as models for more than 70 human infectious diseases of diverse etiologies, including a multitude of agents-bacteria, viruses, fungi, parasites, prions.
Abe   +330 more
core   +1 more source

Neurological manifestations and neuro-invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2 [PDF]

open access: yes, 2020
Background and purpose Infections with coronaviruses are not always confined to the respiratory tract and various neurological manifestations have been reported.
Boon, Paul   +6 more
core   +2 more sources

Viral Meningitis and Encephalitis

open access: yesMedicine, 2001
Abstract Viral meningitis and encephalitis occur at all stages of life. They may represent disease at its primary site of replication (e.g. rabies) or be part of an infection syndrome (e.g. HIV). A large proportion of cases go unconfirmed by laboratory diagnosis despite use of all available laboratory techniques.
openaire   +2 more sources

Detection of West Nile Virus Infection in Viral Encephalitis Cases, China.

open access: yesVector Borne and Zoonotic Diseases, 2019
This study detected West Nile virus (WNV) infection in serum samples of patients clinically diagnosed with viral encephalitis in the Japanese encephalitis virus (JEV) endemic area (seven provinces) and JEV nonendemic area (Xinjiang province) in China ...
Lei Cao   +11 more
semanticscholar   +1 more source

Metabolic Programming Drives Protective and Inflammatory Monocyte Fates in Viral Encephalitis

open access: yesAdvanced Science, EarlyView.
Bone marrow monocytes infiltrate the West Nile virus‐infected brain and differentiate into HIF1‐α⁺ monocyte‐derived cells (MCs) that diverge into protective, antigen‐presenting or inflammatory, iNOS⁺ MCs with distinct metabolic programs and functions.
Claire L. Wishart   +4 more
wiley   +1 more source

Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion. [PDF]

open access: yes, 2016
The host responds to virus infection by activating type I interferon (IFN) signaling leading to expression of IFN-stimulated genes (ISGs). Dysregulation of the IFN response results in inflammatory diseases and chronic infections.
Bozzacco, Leonia   +8 more
core  

Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection [PDF]

open access: yes, 2017
Type I IFNs promote cellular responses to viruses, and IFN receptor (IFNAR) signaling regulates the responses of endothelial cells of the blood-brain barrier (BBB) during neurotropic viral infection.
Ali   +23 more
core   +3 more sources

Characterization of Zika virus endocytic pathways in human glioblastoma cells [PDF]

open access: yes, 2020
Zika virus (ZIKV) infections can cause microcephaly and neurological disorders. However, the early infection events of ZIKV in neural cells remain to be characterized. Here, by using a combination of pharmacological and molecular approaches and the human
Du, T   +11 more
core   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

open access: yesAdvanced Science, EarlyView.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil   +12 more
wiley   +1 more source

Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2018
Significance Viral encephalitis is a frequent medical emergency, often resulting in acute seizures and brain damage, which reduce quality of life, promote the development of epilepsy, and can cause death.
Christopher Käufer   +7 more
semanticscholar   +1 more source

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