Results 231 to 240 of about 4,157,307 (334)

Editorial: HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies

Frontiers in Immunology, 2018
Francesca Chiodi, Gabriella Scarlatti
doaj   +1 more source

Prolonged SARS-CoV-2 Infection and Intra-Patient Viral Evolution in an Immunodeficient Child. [PDF]

Pediatr Infect Dis J, 2023
Filippi M, Ribeiro Amorim M, Soares da Silva M, Schons Gularte J, Demoliner M, Girardi V, de Abreu Goes Pereira VM, Witt Hansen A, Fleck JD, Frohlich J, de-Paris F, Motta Rodrigues G, Aparecida Risczik Arruda Correa J, Machado Arlindo De Mattos E, Minuto Paiva R, Deutschendorf C, Soares Falcetta F, Proença Modena JL, Rosado Spilki F.   +18 more
europepmc   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Artifact‐Minimizing Ultrathin Transparent Electrodes Fabricated via iCVD for In Vivo Optogenetic Stimulation and Neural Signal Monitoring of Primary Visual Cortex

Advanced Functional Materials, EarlyView.
We present ultrathin flexible transparent electrodes through iCVD‐enabled molecular control of 10 nm gold films on poly(dimethylaminomethylstyrene). In vivo validation demonstrated photoelectric artifact reduction vs. opaque electrodes and preservation of natural neural dynamics.
Tae Jin Mun, Minju Kim, Chaesung Kim, Yunyoung Choi, In‐Yeop Baek, Younghak Cho, Gyeongyong Lee, Yerim Jang, Min‐Ho Nam, Wonryung Lee, Maesoon Im, Hyejeong Seong   +11 more
wiley   +1 more source

Rapid response to fast viral evolution using AlphaFold 3-assisted topological deep learning. [PDF]

Virus Evol
Wee J, Wei GW.
europepmc   +1 more source

Amyloidogenic Peptide Fragments Designed From Bacterial Collagen‐like Proteins Form Hydrogel

Advanced Functional Materials, EarlyView.
This study identified amyloidogenic sequence motifs in bacterial collagen‐like proteins and exploited these to design peptides that self‐assemble into β‐sheet fibers and form hydrogels. One hydrogel supported healthy fibroblast growth, showing promise for biocompatible materials. Our work demonstrates that bacterial sequences can be harnessed to create
Vamika Sagar, Xuen J Ng, Lukas Lechel, Ashish Chand Rajwar, Hendrik Bargel, Abhishek A. Jalan   +5 more
wiley   +1 more source

Apollo: a comprehensive GPU-powered within-host simulator for viral evolution and infection dynamics across population, tissue, and cell. [PDF]

Nat Commun
Perera D, Li E, Gordon PM, van der Meer F, Lynch T, Gill J, Church DL, de Koning APJ, Huber CD, van Marle G, Platt A, Long Q.   +11 more
europepmc   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

Higher Rates of Viral Evolution in Chronic Hepatitis B Patients Linked to Predicted T Cell Epitopes. [PDF]

Viruses
Dalegaard MI, Winckelmann A, Fahnøe U, Underwood AP, Pedersen AG, Bollerup S, Bukh J, Weis N.   +7 more
europepmc   +1 more source