Results 71 to 80 of about 614,692 (224)

Viral Hemorrhagic Fevers

, 2013
Viral hemorrhagic fevers have captured the imagination of the public and made their way into popular books and movies by virtue of their extreme virulence and mysterious origins. Since 2001, concerns have grown about the potential use of many hemorrhagic

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Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Early tocilizumab and outcomes in acute necrotizing encephalopathy

Developmental Medicine &Child Neurology, EarlyView.
Early tocilizumab and outcome in acute necrotising encephalopathy. Aim To evaluate the timing and safety of tocilizumab in acute necrotizing encephalopathy (ANE). Method This was a multicentre retrospective study evaluating outcomes (modified Rankin Scale [mRS]) in children with ANE treated with tocilizumab. A logistic regression model determined a cut‐
Velda X Han, Prithuja Poudyal, Vanessa Lee, Arushi Gahlot Saini, Shekeeb S Mohammad, Sekhar C Pillai, Gouri Rao Passi, Naveen Sankhyan, Ahmad Rithauddin Mohamed, Lokesh Lingappa, Hiroshi Sakuma, Russell C Dale, Ming Lim, Terrence Thomas, for The International ANE Study Group   +14 more
wiley   +1 more source

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus

Nature Communications
Zika virus (ZIKV) is a mosquito-borne orthoflavivirus primarily transmitted among humans by Aedes aegypti. Over the past two decades, it has caused significant outbreaks associated with birth defects and neurological disorders.
Shiho Torii, Jennifer S. Lord, Morgane Lavina, Matthieu Prot, Alicia Lecuyer, Cheikh T. Diagne, Oumar Faye, Ousmane Faye, Amadou A. Sall, Michael B. Bonsall, Etienne Simon-Lorière, Xavier Montagutelli, Louis Lambrechts   +12 more
doaj   +1 more source

Viral diversity in wild and urban rodents of Yunnan Province, China

Emerging Microbes and Infections
Rodents represent over 40% of known mammal species and are found in various terrestrial habitats. They are significant reservoirs for zoonotic viruses, including harmful pathogens such as arenaviruses and hantaviruses, yet knowledge of their hosts and ...
Yakhouba Kane, Alexander Tendu, Ruiya Li, Yanhua Chen, Emilio Mastriani, Jiaming Lan, Alice Catherine Hughes, Nicolas Berthet, Gary Wong   +8 more
doaj   +1 more source

First occurrence of Rift Valley fever outbreak in Niger, 2016

Veterinary Medicine and Science, 2019
Rift Valley fever (RVF) is a mosquito‐borne viral zoonosis causing abortions and high mortality among animals, whereas in humans, the disease is usually mild or asymptomatic. In September 2016, the Republic of Niger declared the first RVF outbreak in the
Adamou Lagare, Gamou Fall, Alkassoum Ibrahim, Sani Ousmane, Bacary Sadio, Mariama Abdoulaye, Abdou Alhassane, Ali Elh Mahaman, Bassira Issaka, Fati Sidikou, Maman Zaneidou, Baruani Bienvenue, Harouna Djingarey Mamoudou, Amadou Bailo Diallo, Goumbi Kadadé, Jean Testa, Halima Boubacar Mainassara, Ousmane Faye   +17 more
doaj   +1 more source

Ebola Hemorrhagic Fever Associated with Novel Virus Strain, Uganda, 2007–2008

Emerging Infectious Diseases, 2010
During August 2007–February 2008, the novel Bundibugyo ebolavirus species was identified during an outbreak of Ebola viral hemorrhagic fever in Bundibugyo district, western Uganda.
Joseph F. Wamala, Luswa Lukwago, Mugagga Malimbo, Patrick Nguku, Zabulon Yoti, Monica Musenero, Jackson Amone, William Mbabazi, Miriam Nanyunja, Sam Zaramba, Alex Opio, Julius J. Lutwama, Ambrose O. Talisuna, Sam I. Okware   +13 more
doaj   +1 more source

Clinicopathological Challenge: Giant Cellulitis‐Like Sweet Syndrome With Retiform Petechiae and Vasculitis‐Like Histopathological Features

International Journal of Dermatology, EarlyView.
ABSTRACT We report a patient with chronic myeloid leukemia who developed giant cellulitis‐like Sweet syndrome with concurrent retiform petechiae and vasculitis‐like histopathological changes. This case highlights a potential diagnostic pitfall whereby Sweet syndrome may clinically and histologically mimic cutaneous vasculitis.
Kangjie R. Chua, James J. Koutsis, Patricia M. Lowe   +2 more
wiley   +1 more source

Management of Non‐Plaque‐Induced Gingival Conditions: A Systematic Review—Part 2: Inflammatory and Immune Conditions; Neoplasms; and Gingival Pigmentation

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aims This systematic review assesses current evidence on the management of non‐plaque (dental biofilm)‐induced gingival diseases and conditions (NPIGDs), including (i) inflammatory and immune conditions, (ii) neoplasms and (iii) gingival pigmentations.
Maria Clotilde Carra, Cecile Wasielewski, Bruno Špiljak, Maja Sabalić‐Schoener, Sebastien Jungo, Ivan Alajbeg   +5 more
wiley   +1 more source