Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein [PDF]
, 2014 Infections with human respiratory syncytial virus (HRSV) occur globally in all age groups and can have devastating consequences in young infants. We demonstrate that a vaccine based on the extracellular domain (SHe) of the small hydrophobic (SH) protein ...
Bert Schepens +20 more
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Vaccine Epidemiology and Decision-Making: A Bryant Student Focus [PDF]
, 2018 The Centers for Disease Control and Prevention estimate that influenza has resulted in between 9.2 and 35.6 million illnesses and between 12,000 and 56,000 deaths annually since 2010 (1).
Coburn, Hannah
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T cell immunity as a tool for studying epigenetic regulation of cellular differentiation
Frontiers in Genetics, 2013 Cellular differentiation is regulated by the strict spatial and temporal control of gene expression. This is achieved, in part, by regulating changes in histone post-translational modifications (PTMs) and DNA methylation that in-turn, impact ...
Brendan Edward Russ +3 more
doaj +1 more source
Investigation into the Causes and Severity of the 1918 Influenza Pandemic [PDF]
, 2018 The 1918 Influenza outbreak is regarded as one of the worst pandemics in human history due to its widespread effects across the globe and its high death rate.
Freedenberg, Alex T.
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Modeling the dynamical interaction between epidemics on overlay networks
, 2011 Epidemics seldom occur as isolated phenomena. Typically, two or more viral agents spread within the same host population and may interact dynamically with each other. We present a general model where two viral agents interact via an immunity mechanism as
Antoine Allard +5 more
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Virological aspects of Epstein-Barr virus infections. [PDF]
, 2005 Epstein-Barr virus (EBV) is usually maintained in an asymptomatic and latent form by the host immune system, and primarily by EBV-specific cytotoxic T cells (CTLs).
Kimura, Hiroshi +2 more
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Cell Reports, 2017 Predicting vaccine efficacy remains a challenge. We used a systems vaccinology approach to identify early innate immune correlates of antibody induction in humans receiving the Ebola vaccine rVSV-ZEBOV.
Anne Rechtien +29 more
doaj +1 more source
Differentiation and Protective Capacity of Virus-Specific CD8 [PDF]
, 2017 Noroviruses can establish chronic infections with active viral shedding in healthy humans but whether persistence is associated with adaptive immune dysfunction is unknown.
Bengsch, Bertram +12 more
core +1 more source
Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]
, 2017 The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
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Mucosal immunity and viral infections
Annals of Medicine, 2001 The mucosal surfaces are the first portals of entry for most infectious agents, among which respiratory and intestinal viruses are of greatest epidemiological importance. To combat these infections, the immune system uses unspecific and specific mechanisms.
J, Freihorst, P L, Ogra
openaire +2 more sources