Results 81 to 90 of about 623,045 (205)

Dengue virus IgG and neutralizing antibody titers measured with standard and mature viruses are protective

Nature Communications
The standard dengue virus (DENV) neutralization assay inconsistently predicts dengue protection. We compare how IgG ELISA, envelope domain III (EDIII), or non-structural protein 1 (NS1) binding antibodies, and titers from plaque reduction neutralization ...
Camila D. Odio, Jedas Veronica Daag, Maria Vinna Crisostomo, Charlie J. Voirin, Ana Coello Escoto, Cameron Adams, Lindsay Dahora Hein, Rosemary A. Aogo, Patrick I. Mpingabo, Guillermo Raimundi Rodriguez, Saba Firdous, Maria Abad Fernandez, Laura J. White, Kristal An Agrupis, Jacqueline Deen, Aravinda M. de Silva, Michelle Ylade, Leah C. Katzelnick   +17 more
doaj   +1 more source

Understanding MHC class I presentation of viral antigens by human dendritic cells as a basis for rational design of therapeutic vaccines

Frontiers in Immunology, 2014
Effective viral clearance requires the induction of virus-specific CD8+ cytotoxic T lymphocytes (CTL). Since dendritic cells (DC) have a central role in initiating and shaping virus-specific CTL responses, it is important to understand how DC initiate ...
Nadine eVan Montfoort, Evelyn evan der Aa, Andrea Monique Woltman   +2 more
doaj   +1 more source

Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity

Frontiers in Immunology
BackgroundFactors leading to severe COVID-19 remain partially known. New biomarkers predicting COVID-19 severity that are also causally involved in disease pathogenesis could improve patient management and contribute to the development of innovative ...
Stephane Isnard, Stephane Isnard, Tsoarello Mabanga, Tsoarello Mabanga, Léna Royston, Léna Royston, Léna Royston, Carolina A. Berini, Carolina A. Berini, Simeng Bu, Simeng Bu, Orthy Aiyana, Orthy Aiyana, Hansen Feng, Hansen Feng, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Cecilia T. Costiniuk, Cecilia T. Costiniuk, Joseph Cox, Joseph Cox, Guido Kroemer, Guido Kroemer, Guido Kroemer, Madeleine Durand, Jean-Pierre Routy, Jean-Pierre Routy, Jean-Pierre Routy, the Biobanque Québécoise de la COVID-19 (BQC-19)   +30 more
doaj   +1 more source

Viral Diversity of House Mice in New York City

mBio, 2018
The microbiome of wild Mus musculus (house mouse), a globally distributed invasive pest that resides in close contact with humans in urban centers, is largely unexplored. Here, we report analysis of the fecal virome of house mice in residential buildings
Simon H. Williams, Xiaoyu Che, Joel A. Garcia, John D. Klena, Bohyun Lee, Dorothy Muller, Werner Ulrich, Robert M. Corrigan, Stuart Nichol, Komal Jain, W. Ian Lipkin   +10 more
doaj   +1 more source

From dysbiosis to defense: harnessing the gut microbiome in HIV/SIV therapy

Microbiome
Background Although the microbiota has been extensively associated with HIV pathogenesis, the majority of studies, particularly those using omics techniques, are largely correlative and serve primarily as a basis for hypothesis generation.
Jason M. Brenchley, Sergio Serrano-Villar   +1 more
doaj   +1 more source

Gut infection and dysbiosis are hallmarks of severe SARS-CoV-2 variants

npj Viruses
SARS-CoV-2, the virus behind the COVID-19 pandemic, is primarily a respiratory pathogen, with host entry mediated by the ACE2 receptor that determines viral tropism.
Santhosh K. Nagaraj, Christy M. Joy, Rishad Shiraz, Rohan Narayan, Sumandeep Kaur, Oyahida Khatun, Sagar Dubey, James Ng, Nischay Mishra, Shashank Tripathi   +9 more
doaj   +1 more source

IFI207, a young and fast‐evolving protein, controls retroviral replication via the STING pathway

mBio
Mammalian AIM-2-like receptor (ALR) proteins bind nucleic acids and initiate production of type I interferons or inflammasome assembly, thereby contributing to host innate immunity.
Eileen A. Moran, Karen Salas-Briceno, Wenming Zhao, Takuji Enya, Alexya N. Aguilera, Ivan Acosta, Francis Alonzo, Dara Kiani, Judith Behnsen, Catalina Alvarez, Thomas M. Keane, David J. Adams, Jingtao Lilue, Susan R. Ross   +13 more
doaj   +1 more source

Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host

, 2016
The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are successively infected with different strains within a short timeframe provide insight into the underlying viral dynamics and the ...
Ada W.C. Yan, Antia, Badovinac, Barber, Beauchemin, Blattman, Bocharov, Bodewes, Boianelli, Boon, Bortnick, Braciale, Brown, Brown, Bui, Cao, Carolan, Carpenter, Chao, Christensen, Crowe, Davenport, De Boer, Dobrovolny, Epstein, Faroudi, Grayson, Grebe, Greenbaum, Hancioglu, Handel, Hou, Iwasaki, James M. McCaw, Jameson, Jane M. Heffernan, Jodie McVernon, Kaech, Kaech, Karen L. Laurie, Kees, Komadina, Kreijtz, Kris, Kylie M. Quinn, Laurie, Laurie, Lee, Lehmann-Grube, Luciani, Luckheeram, Marchuk, Martin, McElhaney, McMichael, Mehlhop-Williams, Miao, Miao, Murali-Krishna, Nicole L. La Gruta, Nowak, Pawelek, Pengxing Cao, Petrie, Quinn, Rammensee, Selin, Shin, Smith, Smith, Smith, Sridhar, Steel, Sze, Tanchot, Terajima, Tscharke, van Stipdonk, Veiga-Fernandes, Veiga-Fernandes, Wells, Wherry, Wirth, Wodarz, Wodarz, Yan, Yap, Yewdell, Yewdell, Zarnitsyna, Zehn   +90 more
core   +1 more source

Development of Cross-Reactive Live Attenuated Influenza Vaccine Candidates against Both Lineages of Influenza B Virus

Vaccines
Background: Influenza viruses continue to cause a significant social and economic burden globally. Vaccination is recognized as the most effective measure to control influenza.
Pei-Fong Wong, Irina Isakova-Sivak, Ekaterina Stepanova, Elena Krutikova, Ekaterina Bazhenova, Andrey Rekstin, Larisa Rudenko   +6 more
doaj   +1 more source

Circulating LPS and (1→3)-β-D-Glucan: A Folie à Deux Contributing to HIV-Associated Immune Activation

Frontiers in Immunology, 2019
Immune activation is the driving force behind the occurrence of AIDS and non-AIDS events, and is only partially reduced by antiretroviral therapy (ART).
Rayoun Ramendra, Rayoun Ramendra, Rayoun Ramendra, Stéphane Isnard, Stéphane Isnard, Vikram Mehraj, Jun Chen, Jun Chen, Yonglong Zhang, Malcolm Finkelman, Jean-Pierre Routy, Jean-Pierre Routy, Jean-Pierre Routy   +12 more
doaj   +1 more source