Results 61 to 70 of about 2,220,366 (311)

The Role of Cluster of Differentiation 39 (CD39) and Purinergic Signaling Pathway in Viral Infections

, 2023
CD39 is a marker of immune cells such as lymphocytes and monocytes. The CD39/CD73 pathway hydrolyzes ATP into adenosine, which has a potent immunosuppressive effect.
Alaa Elsaghir, Ibrahim M. Sayed, Ehsan M. W. El-Sabaa, Mohamed A. El-Mokhtar, Abdulrahman K. Ahmed, Sayed F. Abdelwahab   +5 more
core   +1 more source

Defensins in Viral Infections [PDF]

Journal of Innate Immunity, 2009
Defensins are antimicrobial peptides important to innate host defense. In addition to their direct antimicrobial effect, defensins modulate immune responses. Increasing evidence indicates that defensins exhibit complex functions by positively or negatively modulating infections of both enveloped and non-enveloped viruses.
Jian, Ding, Yi-Ying, Chou, Theresa L, Chang   +2 more
openaire   +2 more sources

Role of hepatitis C virus core antigen assay in hepatitis C care in developing country

Egyptian Liver Journal, 2021
Background The World Health Organization (WHO) aims to achieve global hepatitis C elimination by 2030, defined as diagnosis of 90% of infected individuals and treating 80% of them.
Ouafa Kallala, Saoussen Kacem, Imene Fodha, Bruno Pozzetto, Trabelsi Abdelhalim   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

IFN-γ derived from activated human CD4+ T cells inhibits the replication of SARS-CoV-2 depending on cell-type and viral strain

Scientific Reports
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination elicit both T cell and B cell immune responses in immunocompetent individuals.
Jun Shimizu, Tadahiro Sasaki, Guang Han Ong, Ritsuko Koketsu, Yoshihiro Samune, Emi E. Nakayama, Tetsuharu Nagamoto, Yuki Yamamoto, Kazuo Miyazaki, Tatsuo Shioda   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Aetiological role of viral and bacterial infections in acute adult lower respiratory tract infection (LRTI) in primary care [PDF]

, 2005
Background: Lower respiratory tract infections (LRTI) are a common reason for consulting general practitioners (GPs). In most cases the aetiology is unknown, yet most result in an antibiotic prescription.
McHugh, TD, Gillespie, S H, Creer, D.D., Wallace, P.G., McHugh, T.D., Gillespie, S.H., Creer, D D, Johnston, S.L., Johnston, AR, Wallace, P G, Johnston, A R, Dilworth, J P, Sanderson, G, Sanderson, G., Johnston, S L, Ling, C., Johnston, A.R., McHugh, T D, Creer, DD, Dilworth, JP, Patel, S, Dilworth, J.P., Gillespie, SH, Ling, C, Patel, S., Wallace, PG, Johnston, SL   +26 more
core   +1 more source

Epidemiology and Transmission Dynamics of Viral Encephalitides in West Africa

, 2023
Encephalitis is an inflammation of the brain, often caused by an autoimmune reaction, or in most cases because of a direct viral, bacterial, or parasitic infection.
Olalekan Chris Akinsulie, Ridwan Olamilekan Adesola, Ifeoluwa Peace Oladapo, Abdulafees Hamzat, Victor Ayodele Aliyu   +4 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Cough formation in viral infections in children

, 2014
Using a multidisciplinary approach, Human Respiratory Viral Infections is set at the level between the definitive reference work and an essential clinical manual. Exploring recent advances in human respiratory viral research, the text builds on the basic
Anne B. Chang, Mackay, Ian M., Ian M. Mackay, O'Grady, Kerry-Ann F., Chang, Anne B., O’Grady Kerry-Ann F.   +5 more
core   +1 more source