Results 71 to 80 of about 2,220,366 (311)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Viral Infections in Immunocompromised Hosts

This Special Issue comprises 11 manuscripts and 1 editorial. The manuscripts include 4 research papers and 7 reviews, with one correction to a review article.

core   +1 more source

T Cell Responses Induced by DNA Vaccines Based on the DENV2 E and NS1 Proteins in Mice: Importance in Protection and Immunodominant Epitope Identification

Frontiers in Immunology, 2019
The importance of the cellular immune response against DENV has been increasingly highlighted in the past few years, in particular for vaccine development.
Paolla B. A. Pinto, Maysa L. Assis, Adriana L. Vallochi, Agatha R. Pacheco, Lauro M. Lima, Kátia R. L. Quaresma, Bernardo A. S. Pereira, Simone M. Costa, Ada M. B. Alves   +8 more
doaj   +1 more source

Modulation of Cell Surface Receptor Expression by Modified Vaccinia Virus Ankara in Leukocytes of Healthy and HIV-Infected Individuals

Frontiers in Immunology, 2020
Viral vectors are increasingly used as delivery means to induce a specific immunity in humans and animals. However, they also impact the immune system, and it depends on the given context whether this is beneficial or not.
Adrien Leite Pereira, Quentin Jouhault, Ernesto Marcos Lopez, Antonio Cosma, Olivier Lambotte, Olivier Lambotte, Olivier Lambotte, Roger Le Grand, Michael H. Lehmann, Nicolas Tchitchek   +9 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Emerging Viral Infections

Seminars in Pediatric Neurology, 2012
Unique disorders appear episodically in human populations and cause life-threatening systemic or neurological disease. Historical examples of such disorders include von Economo encephalitis, a disorder of presumed viral etiology; acquired immune deficiency syndrome, caused by the human immunodeficiency virus; and severe acute respiratory syndrome ...
openaire   +2 more sources

Prenatal Infection of the Newborns as an Epidemic Marker in Maternity Hospitals

Эпидемиология и вакцинопрофилактика, 2019
Relevance.  According  to  official  statistics  prenatal  infections  outweigh  neonatal  purulent-septic  infections.  The  clinical  picture of prenatal infections is not the specifics.
S. S. Smirnova, A. A. Golubkova, A. V. Alimov, V. G. Akimkin   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Vaccine Strategies Against RNA Viruses: Current Advances and Future Directions

Vaccines
The development of vaccines against RNA viruses has undergone a rapid evolution in recent years, particularly driven by the COVID-19 pandemic. This review examines the key roles that RNA viruses, with their high mutation rates and zoonotic potential ...
Kuei-Ching Hsiung, Huan-Jung Chiang, Sebastian Reinig, Shin-Ru Shih   +3 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source