Results 91 to 100 of about 2,220,366 (311)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Parainfluenza virus 5 genomes are located in viral cytoplasmic bodies whilst the virus dismantles the interferon-induced antiviral state of cells [PDF]

, 2009
This work was supported by the Wellcome Trust.Although the replication cycle of parainfluenza virus type 5 (PIV5) is initially severely impaired in cells in an interferon (IFN)-induced antiviral state, the virus still targets STAT1 for degradation.
Carlos, T S, Schneider, M, Simas, J P, Randall, Richard Edward, Young, Dan Frushard   +4 more
core   +1 more source

Viral infections and allergies

Immunobiology, 2007
Respiratory viral infections have been implicated in the origin of, protection from and exacerbation of allergy-related symptoms in a variety of ways. Viral infections are closely linked to infantile wheezing. Severe bronchiolitis in early infancy may predispose to chronic childhood asthma as well as allergic sensitization; alternatively it could ...
Xepapadaki, Paraskevi, Papadopoulos, Nikolaos G.; id_orcid 0000-0002-4448-3468   +1 more
openaire   +4 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Genetics, recombination and clinical features of human rhinovirus species C (HRV-C) infections; interactions of HRV-C with other respiratory viruses [PDF]

, 2009
To estimate the frequency, molecular epidemiological and clinical associations of infection with the newly described species C variants of human rhinoviruses (HRV), 3243 diagnostic respiratory samples referred for diagnostic testing in Edinburgh were ...
Anne Wisdom, Gaunt, Eleanor R, Gaunt, E., Harvala, H., McWilliam Leitch, E.C., Aldona E Kutkowska, E Carol McWilliam Leitch, Kate Templeton, Kutkowska, A.E., Templeton, K., Peter Simmonds, Wisdom, A., Heli Harvala, Simmonds, P., Eleanor Gaunt   +14 more
core   +2 more sources

Nanoparticle Vaccines Based on the Truncated VZV gE Elicit a Robust Immune Response in Mice

Vaccines
Background: Herpes zoster (HZ), caused by the reactivation of varicella-zoster virus (VZV), primarily affects elderly populations worldwide. Although current recombinant HZ vaccines show strong immunogenicity, their high cost and potential side effects ...
Tianxin Shi, Hai Li, Jiehui Wu, Hongqiao Hu, Jie Jiang, Ruichen Wang, Ziyi Li, Qianqian Cui, Shihong Fu, Kai Nie, Fan Li, Qikai Yin, Huanyu Wang, Songtao Xu   +13 more
doaj   +1 more source

Targeted surveillance reveals native and invasive mosquito species infected with Usutu virus

Parasites & Vectors, 2019
Background The emergence of Usutu virus (USUV) in Europe was first reported in Austria, 2001, and the virus has since spread to many European countries. Initial outbreaks are marked by a mass die-off of European blackbirds (Turdus merula) and other bird ...
Jeremy V. Camp, Jolanta Kolodziejek, Norbert Nowotny   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

UBL5 and Its Role in Viral Infections

Unlike other ubiquitin-like family members, UBL5 is structurally and functionally atypical, and a novel role in various biological processes and diseases has been discovered.
Yanhua He, Xijia Feng, Yangang Liu, Zhongtian Qi, Xijing Qian, Liancheng Xia, Yifan Sui   +6 more
core   +1 more source