Results 101 to 110 of about 2,220,366 (311)

Viral Infection and Apoptosis [PDF]

Viruses, 2017
Viruses are master molecular manipulators, and evolved to thrive and survive in all species.[...]
openaire   +4 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Towards Understanding and Identification of Human Viral Co-Infections

Viral co-infections, in which a host is infected with multiple viruses simultaneously, are common in the human population. Human viral co-infections can lead to complex interactions between the viruses and the host immune system, affecting the clinical ...
Hang-Yu Zhou, Aiping Wu, Heng Zheng, Hui Wu   +3 more
core   +1 more source

Genetic Characteristics of Acinetobacter baumannii Isolates Circulating in an Intensive Care Unit of an Infectious Diseases Hospital During the COVID-19 Pandemic

Pathogens
During the COVID-19 pandemic, a significant increase in the spread of healthcare-associated infections (HAIs) and antimicrobial resistance (AMR) was observed.
Svetlana S. Smirnova, Dmitry D. Avdyunin, Marina V. Holmanskikh, Yulia S. Stagilskaya, Nikolai N. Zhuikov, Tarek M. Itani   +5 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Hepatic involvement in major respiratory viral infections

Common respiratory viral pathogens, including SARS-CoV-2, influenza viruses, and respiratory syncytial virus (RSV), can lead to extrapulmonary manifestations, including clinically significant liver involvement. This review synthesizes current evidence on
Piotr Rzymski, Krystyna Dobrowolska, Michał Brzdęk, Dorota Zarębska-Michaluk, Robert Flisiak   +4 more
core   +1 more source

The effects of early syphilis on CD4 counts and HIV-1 RNA viral loads in blood and semen [PDF]

, 2005
Objective: To examine the effect of early syphilis on blood and semen plasma HIV-1 viral loads and CD4 counts.Methods: In a retrospective case-control study, blood plasma HIV-1 viral loads and CD4 counts in cases during early syphilis ( n = 63, 27 ...
Weller, IVD, Copas, AJ, Sadiq, ST, Edwards, SJ, Bennett, J, French, P, Kaye, S, McSorley, J, Kirk, S   +8 more
core  

The Results of Two-Year Monitoring of Compliance with the Requirements of Sanitary Legislation in Infectious Diseases Hospitals of the Russian Federation for the Treatment of Patients with COVID-19

Проблемы особо опасных инфекций
In the context of the COVID-19 pandemic, the problem of biological safety of patients and staff of medical organizations has reached a new level. The peculiarities of the functioning of infectious diseases hospitals for the treatment of patients with ...
A. V. Semenov, S. S. Smirnova, I. A. Egorov, N. N. Zhuikov   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Evidence of virus interference? Increased risk of non-influenza respiratory virus infections associated with receipt of inactivated influenza vaccine [PDF]

, 2012
BACKGROUND: Seasonal influenza vaccination is effective in preventing influenza infection and disease in healthy school-age children, while influenza vaccination is not generally thought to affect the risk of non-influenza respiratory virus infections (e.
Nishiura, H, Peiris, JSM, Cowling, BJ, Ip, DKM, Leung, GM, Chan, KH, Ng, S, Chiu, SS, Fang, VJ   +8 more
core