Results 101 to 110 of about 5,389,784 (354)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Role of hepatitis C virus core antigen assay in hepatitis C care in developing country

Egyptian Liver Journal, 2021
Background The World Health Organization (WHO) aims to achieve global hepatitis C elimination by 2030, defined as diagnosis of 90% of infected individuals and treating 80% of them.
Ouafa Kallala, Saoussen Kacem, Imene Fodha, Bruno Pozzetto, Trabelsi Abdelhalim   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

IFN-γ derived from activated human CD4+ T cells inhibits the replication of SARS-CoV-2 depending on cell-type and viral strain

Scientific Reports
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination elicit both T cell and B cell immune responses in immunocompetent individuals.
Jun Shimizu, Tadahiro Sasaki, Guang Han Ong, Ritsuko Koketsu, Yoshihiro Samune, Emi E. Nakayama, Tetsuharu Nagamoto, Yuki Yamamoto, Kazuo Miyazaki, Tatsuo Shioda   +9 more
doaj   +1 more source

Non-Polio Enterovirus Surveillance in the Ural Federal District and Western Siberia, 2022: Is There a Need for a Vaccine?

Vaccines, 2023
Human non-polio enteroviruses (NPEVs) are the etiological agents involved in most cases of hand-foot-and-mouth disease (HFMD), herpangina and aseptic meningitis.
Tarek M. Itani, Vladislav I. Chalapa, Vasilii N. Slautin, Roman O. Bykov, Bolat S. Imangaliev, Polina K. Starikova, Aleksandr G. Sergeev, Aleksandr V. Semenov   +7 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Differentiation and Protective Capacity of Virus-Specific CD8 [PDF]

, 2017
Noroviruses can establish chronic infections with active viral shedding in healthy humans but whether persistence is associated with adaptive immune dysfunction is unknown.
Bengsch, Bertram, Cosma, Gabriela L., Eisenlohr, Laurence C., Lau, Chi Wai, Manne, Sasikanth, Nice, Timothy J., Palko, Olesya, Pattekar, Ajinkya, Sun, Yuhang, Tacheva, Ralitza, Tomov, Vesselin T., Virgin, Herbert W., Wherry, E. John   +12 more
core   +1 more source

Redox-Modulating Agents in the Treatment of Viral Infections

International Journal of Molecular Sciences, 2020
Viruses use cell machinery to replicate their genome and produce viral proteins. For this reason, several intracellular factors, including the redox state, might directly or indirectly affect the progression and outcome of viral infection.
Paola Checconi, M. De Angelis, M. E. Marcocci, A. Fraternale, M. Magnani, A. Palamara, L. Nencioni   +6 more
semanticscholar   +1 more source

Glycofullerenes Inhibit Viral Infection [PDF]

Biomacromolecules, 2013
Water-soluble glycofullerenes based on a hexakis-adduct of [60]fullerene with an octahedral addition pattern are very attractive compounds providing a spherical presentation of carbohydrates. These tools have been recently described and they have been used to interact with lectins in a multivalent manner.
Luczkowiak J., Muñoz A., Sánchez-Navarro M., Ribeiro-Viana R., Ginieis A., Illescas B.M., Martín, Nazario, Delgado R., Rojo J.   +8 more
openaire   +4 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source