Results 101 to 110 of about 462,588 (307)

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

SARS-CoV-2 Viral Load in Stool and Nasopharyngeal/Oropharyngeal Samples: Implications for Clinical Progression in Severe COVID-19 Patients

International Journal of Microbiology
The SARS-CoV-2 RNA load in different specimens has been analyzed to evaluate its correlation with disease outcomes and other factors. However, conflicting results have emerged due to variations in study design.
Mariane Vedovatti Monfardini, Brena Ramos Athaydes, Priscila Marinho Abreu, Fernanda Laís Lima Fonseca, Roberta Ferreira Ventura Mendes, Juliana Couto-Vieira, Frederico Firme Figueira, Priscilla Aquino Martins, Regina Keller, Sandra Lucia Ventorin von Zeidler, Liliana Cruz Spano   +10 more
doaj   +1 more source

The case for viral load testing in adolescents in resource-limited settings. [PDF]

, 2017
INTRODUCTION: The success of HIV treatment programmes globally has resulted in children with perinatally acquired HIV reaching adolescence in large numbers. The number of adolescents living with HIV is growing further due to persisting high HIV incidence
Adejumo, Agwu, Agwu, Battles, Betz, Blakemore, Blum, Boerma, Campbell, Castro, Chaix, Choudhury, Clark, Cluver, Davies, Dellar, Ferrand, Germanaud, Gody, Govender, Haydon, Houck, Idele, Kamya, Kebe, Kim, Kyaw, Lowenthal, Marston, Martinez, McAteer, Menson, Mocroft, Muri, Nachega, Ndembi, Price, Rao, Reif, Ritchie, Roberts, Rossum, Ruel, Ryscavage, Salou, Sawyer, Sedgh, Sigaloff, Smith, Sohn, Stover, Taddeo, Turner, Van Dyke, Viani, WHO, Zhang   +56 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

East African HIV care: depression and HIV outcomes. [PDF]

, 2019
Importance:Depression is a common co-morbidity for people living with HIV (PLWH) and is associated with elevated plasma HIV RNA levels. While depression correlates with deficits in antiretroviral (ARV) adherence, little data exist to inform the ...
Adamu, Y, Ake, JA, Kiweewa, F, Maganga, L, Maswai, J, McCulloch, CE, Meffert, SM, Neylan, TC, Owuoth, J, Polyak, CS, Valcour, VG   +10 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Systematic review of the accuracy of plasma preparation tubes for HIV viral load testing.

PLoS ONE, 2019
Expanding access to HIV viral load testing is essential to improving the care and treatment of people living with HIV/AIDS and ending the AIDS epidemic. Though significant investments have been made in the past five years, many high burden, low resource ...
Robert Luo, Jessica Markby, Jilian Sacks, Lara Vojnov   +3 more
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe [PDF]

, 2017
HIV-1 set-point viral load—the approximately stable value of viraemia in the first years of chronic infection—is a strong predictor of clinical outcome and is highly variable across infected individuals.
Albert, J, Bakker, M, Bannert, N, Berkhout, B, Bezemer, D, Blanquart, F, Cornelissen, M, Fellay, J, Fransen, K, Fraser, C, Gall, A, Gourlay, AJ, Grabowski, MK, Gunsenheimer-Bartmeyer, B, Günthard, HF, Hall, M, Hillebregt, M, Kellam, P, Kivelä, P, Kouyos, R, Laeyendecker, O, Liitsola, K, Meyer, L, Ong, SH, Porter, K, Reiss, P, Ristola, M, van Sighem, A, Vanham, G, Wymant, C   +29 more
core