Results 131 to 140 of about 3,712,649 (404)

Revealing patterns in HIV viral load data and classifying patients via a novel machine learning cluster summarization method [PDF]

arXiv, 2018
HIV RNA viral load (VL) is an important outcome variable in studies of HIV infected persons. There exists only a handful of methods which classify patients by viral load patterns. Most methods place limits on the use of viral load measurements, are often specific to a particular study design, and do not account for complex, temporal variation.
arxiv  

Transmissibility of COVID-19 depends on the viral load around onset in adult and symptomatic patients

PLoS ONE, 2020
Objective To investigate the relationship between viral load and secondary transmission in novel coronavirus disease 2019 (COVID-19). Methods Epidemiological and clinical data were obtained from immunocompetent laboratory-confirmed patients with COVID-19
H. Kawasuji, Y. Takegoshi, M. Kaneda, A. Ueno, Y. Miyajima, Koyomi Kawago, Y. Fukui, Y. Yoshida, Miyuki Kimura, H. Yamada, I. Sakamaki, H. Tani, Y. Morinaga, Yoshihiro Yamamoto   +13 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

HIV Viral Load Response to Antiretroviral Therapy According to the Baseline CD4 Cell Count and Viral Load [PDF]

JAMA, 2001
It is unclear whether delay in initiation of antiretroviral therapy (ART) may lead to a poorer viral load response for patients with human immunodeficiency virus (HIV).To characterize the relationship of viral load response to ART with baseline CD4 cell count and baseline viral load.Inception cohort of 3430 therapy-naive patients with HIV, of whom 3226
Phillips, AN, Staszewski, S, Weber, R, Kirk, O, Francioli, P, Miller, V, Vernazza, P, Lundgren, Jens Dilling, Ledergerber, B   +8 more
openaire   +3 more sources

Two-year follow-up of macaques developing intermittent control of the human immunodeficiency virus homolog simian immunodeficiency virus SIVmac251 in the chronic phase of infection [PDF]

, 2015
Off-therapy control of viremia by HIV-infected individuals has been associated with two likely players: a restricted viral reservoir and an efficient cell-mediated immune response.
Arts, Eric, Biffoni, Mauro, Chung, Hye Kyung, Farrell, Nicholas, Labranche, Celia, Lewis, Mark G., Montefiori, David, Nickel, Gabrielle, Pal, Ranajit, PALAMARA, ANNA TERESA, Robert Guroff, Marjorie, Sacha, Jonah B., Savarino, Andrea, Shytaj, Iart Luca, Vargas Inchaustegui, Diego   +14 more
core   +2 more sources

Providing anti-retroviral treatment did not achieve the ambition of ‘Joint united nations program on HIV/AIDS (UNAIDS) among HIV positive patient in Ethiopia’: a systematic review and meta-analysis

Journal of Pharmaceutical Policy and Practice
Introduction: Antiretroviral Treatment (ART) has great importance in reducing viral load. Though a global effort was made to suppress viral load, the level of viral load suppression among ART patients is still high in Ethiopia. Objective: This study aims
Tamirat Melis, Tadesse Sahle, Kassahun Haile, Abebe Timerga, Amare Zewdie, Yohannes Wegu, Kebebush Zepire, Jemal Bedewi   +7 more
doaj   +1 more source

Trend of viral load during the first, second, and third wave of COVID-19 in the Indian Himalayan region: an observational study of the Uttarakhand state

Frontiers in Microbiology
India had faced three waves throughout the Coronavirus disease 2019 (COVID-19) pandemic, which had already impacted economic lives and affected the healthcare setting and infrastructure.
Shailender Negi, Diksha, Deepjyoti Kalita, Neeraj Ranakoti, Ashish Negi, Diksha Kandwal, Shailesh Kumar Gupta, Yogendra Pratap Mathuria, Yogendra Pratap Mathuria   +8 more
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Promoting adherence to antiretroviral therapy: the experience from a primary care setting in Khayelitsha, South Africa. [PDF]

, 2004
OBJECTIVE: To describe the approach used to promote adherence to antiretroviral therapy (ART) and to present the outcomes in the first primary care public sector ART project in South Africa.
Asselman, V, Boulle, A, Coetzee, D, Goemaere, E, Hildebrand, K, Van Cutsem, G   +5 more
core   +1 more source

Predicting virological decay in patients starting combination antiretroviral therapy. [PDF]

, 2016
OBJECTIVE: Model trajectories of viral load measurements from time of starting combination antiretroviral therapy (cART), and use the model to predict whether patients will achieve suppressed viral load (≤200 copies/ml) within 6-months of starting cART ...
Anastos, Andrade, Cescon, Cozzi Lepri, Diggle, Glas, Grabar, Gunthard, Hartzell, Haubrich, Herz, Ho, Knobel, Kuritzkes, Marconi, McGinnis, Mittler, Mueller, Notermans, Pence, Perelson, Polis, Riddler, Royston, Rubin, Simoni, Smith, Spector, Taylor, Taylor, Taylor, Tucker, Wei, Weintrob, Weintrob, Williams, Wu, Wu, Wu, Wu, Yamashita   +40 more
core   +4 more sources