Results 51 to 60 of about 3,662,996 (361)

Use of multi-trait and random regression models to identify genetic variation in tolerance to porcine reproductive and respiratory syndrome virus

Genetics Selection Evolution, 2017
Background A host can adopt two response strategies to infection: resistance (reduce pathogen load) and tolerance (minimize impact of infection on performance).
Graham Lough, Hamed Rashidi, Ilias Kyriazakis, Jack C. M. Dekkers, Andrew Hess, Melanie Hess, Nader Deeb, Antti Kause, Joan K. Lunney, Raymond R. R. Rowland, Han A. Mulder, Andrea Doeschl-Wilson   +11 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Predictors of HIV Viral Load Suppression After Enhanced Adherence Counseling, Nekemte, Ethiopia

Journal of Epidemiology and Global Health
Background Enhanced adherence counseling refers to the counseling intervention for Human Immunodeficiency Virus (HIV) patients with an elevated viral load result, a viral load of > 1000 copies/ml, on a routine or need-based viral load test.
Yohannis Mosisa, Adisu Ewunetu, Kitesa Biresa Duftu, Bayise Biru, Debelo Diriba, Adisu Tafari Shama, Melese Lemi, Getahun Fetensa, Bikila Regassa Feyisa   +8 more
doaj   +1 more source

Relationships between Viral Load and the Clinical Course of COVID-19

Viruses, 2021
To predict the clinical outcome of coronavirus disease-2019 (COVID-19), we examined relationships among epidemiological data, viral load, and disease severity.
H. Tsukagoshi, Daisuke Shinoda, M. Saito, Kaori Okayama, Mitsuru Sada, H. Kimura, N. Saruki   +6 more
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Prognostic value of severe acute respiratory syndrome coronavirus‐2 viral load and antibodies in patients hospitalized with COVID‐19

Clinical and Translational Science, 2023
Observational studies have identified the potential prognostic value for severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) viral load and anti‐SARS‐CoV‐2 antibodies in coronavirus disease 2019 (COVID‐19). However, viral load in nasopharyngeal (
Rebecca N. Bauer, Anastasia Teterina, Haridha Shivram, Jacqueline McBride, Carrie M. Rosenberger, Fang Cai, Min Bao, Larry Tsai, Oliver Gordon, Ivan T. Lee, Jeffrey J. Wallin, Danielle Porter, Kavita Juneja, Gregory Camus, Ivan O. Rosas, Steffen Wildum   +15 more
doaj   +1 more source

Impact of viral load at admission on the development of respiratory failure in hospitalized patients with SARS-CoV-2 infection

European Journal of Clinical Microbiology and Infectious Diseases, 2021
The aim of our study was to elucidate if SARS-CoV-2 viral load on admission, measured by real-time reverse transcriptase–polymerase chain reaction (rRT-PCR) cycle threshold (Ct) value on nasopharyngeal samples, was a marker of disease severity.
C. de la Calle, A. Lalueza, M. Mancheño-Losa, G. Maestro-de la Calle, J. Lora-Tamayo, E. Arrieta, A. Garcia-Reyne, I. Losada, Borja de Miguel, R. Díaz-Simón, F. López‐Medrano, M. Fernández-Ruiz, O. Carretero, R. San Juan, J. Aguado, C. Lumbreras   +15 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

High heritability is compatible with the broad distribution of set point viral load in HIV carriers.

PLoS Pathogens, 2015
Set point viral load in HIV patients ranges over several orders of magnitude and is a key determinant of disease progression in HIV. A number of recent studies have reported high heritability of set point viral load implying that viral genetic factors ...
Sebastian Bonhoeffer, Christophe Fraser, Gabriel E Leventhal   +2 more
doaj   +1 more source

Evaluation of HIV viral load turnaround time in Moshi, Tanzania

Journal of Infection in Developing Countries, 2022
Introduction: Viral load measurement is an important gold standard for monitoring anti-retroviral treatment among people living with human immunodeficiency virus.
Elizabeth L Moirana, Eva Prosper Muro, Ireen Eliah Kiwelu, James Kimaro, Rachel Manongi, Zahra Theilgaard, Terese L Katzenstein   +6 more
doaj   +1 more source