Results 51 to 60 of about 257,291 (319)

Evaluation of HIV viral load turnaround time in Moshi, Tanzania

Journal of Infection in Developing Countries, 2022
Introduction: Viral load measurement is an important gold standard for monitoring anti-retroviral treatment among people living with human immunodeficiency virus.
Elizabeth L Moirana, Eva Prosper Muro, Ireen Eliah Kiwelu, James Kimaro, Rachel Manongi, Zahra Theilgaard, Terese L Katzenstein   +6 more
doaj   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Cumulative exposure to viremia: Methods for the implementation of standardized variables in longitudinal HIV studies

MethodsX, 2023
Measures of viremic exposure over time, including HIV viral copy-years or durable viremic suppression, may be more relevant measures of viral load exposure for comorbid outcomes and mortality than single time point viral load measures. However, there are
Benjamin W. Barrett, Katherine McGowan, Christian Landon, Jinbing Zhang, Sabina Haberlen, Alison G. Abraham   +5 more
doaj  

The effect of motion of respiratory droplets on propagation of viral particles [PDF]

arXiv, 2021
In this work we investigate viral load propagation due to liquid droplets expelled during respiratory actions. We describe a mechanism of the transmission of such evaporating system and analyze dependence on several ambient parameters for different respiratory processes, such as sneezing, coughing and speaking.
arxiv  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Potential Pitfalls in Estimating Viral Load Heritability [PDF]

Trends in Microbiology, 2016
AbstractIn HIV patients, the set-point viral load (SPVL) is the most widely used predictor of disease severity. Yet SPVL varies over several orders of magnitude between patients. The heritability of SPVL quantifies how much of the variation in SPVL is due to transmissible viral genetics.
Gabriel E. Leventhal, Gabriel E. Leventhal, Sebastian Bonhoeffer   +2 more
openaire   +4 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

HIV viral suppression and risk of viral rebound in patients on antiretroviral therapy: a two- year retrospective cohort study in Northern Tanzania

BMC Infectious Diseases
Background The world is moving towards the third target of the Joint United Nations Programme on HIV/AIDS to ensure most people receiving antiretroviral therapy (ART) are virologically suppressed.
Monica S Kahabuka, Yimtubezinash Woldeamanuel, Peter M. Mbelele, Emmanuel A. Mpolya, Stellah G. Mpagama, Jonas P. Kessy, Tsegahun Manyazewal   +6 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source