Results 101 to 110 of about 664,008 (371)

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Cryo-electron tomography of Marburg virus particles and their morphogenesis within infected cells.

PLoS Biology, 2011
Several major human pathogens, including the filoviruses, paramyxoviruses, and rhabdoviruses, package their single-stranded RNA genomes within helical nucleocapsids, which bud through the plasma membrane of the infected cell to release enveloped virions.
Tanmay A M Bharat, James D Riches, Larissa Kolesnikova, Sonja Welsch, Verena Krähling, Norman Davey, Marie-Laure Parsy, Stephan Becker, John A G Briggs   +8 more
doaj   +1 more source

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source

Assembly of nucleocapsids with cytosolic and membrane-derived matrix proteins of vesicular stomatitis virus.

Virology, 1999
During budding of vesicular stomatitis virus (VSV), the viral matrix (M) protein binds the viral nucleocapsid to the host plasma membrane and condenses the nucleocapsid into the tightly coiled nucleocapsid-M protein (NCM) complex observed in virions.
E. Flood, D. Lyles
semanticscholar   +1 more source

A new census of protein tandem repeats and their relationship with intrinsic disorder [PDF]

, 2020
Protein tandem repeats (TRs) are often associated with immunity-related functions and diseases. Since that last census of protein TRs in 1999, the number of curated proteins increased more than seven-fold and new TR prediction methods were published. TRs
Anisimova, Maria, Delucchi, Matteo, Elofsson, Arne, Sachenkova, Oxana, Schaper, Elke   +4 more
core   +1 more source

Reverse genetics system for Chandipura virus: Tagging the viral matrix protein with green fluorescent protein

Virus Research, 2011
Chandipura virus (CV; genus Vesiculovirus, family Rhabdoviridae) is an emerging arbovirus, responsible for a number of outbreaks of severe viral encephalitis affecting children in India. A reverse genetics system has been constructed which allows recovery of infectious recombinant CV (rCV) entirely from cDNA.
Anthony C. Marriott, Crystal A. Hornsey
openaire   +3 more sources

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein.

PLoS Pathogens
Several Old World and New World Mammarenavirus are responsible for hemorrhagic fever in humans. These enveloped viruses have a bi-segmented ambisense RNA genome that encodes four proteins.
Xavier Carnec, Virginie Borges-Cardoso, Stéphanie Reynard, Heinrich Kowalski, Jean-Charles Gaillard, Mathieu Mateo, Jean Armengaud, Sylvain Baize   +7 more
doaj   +1 more source

Structural studies on the Ebola virus matrix protein VP40 indicate that matrix proteins of enveloped RNA viruses are analogues but not homologues

FEMS Microbiology Letters, 2004
Matrix proteins are the driving force of assembly of enveloped viruses. Their main function is to interact with and polymerize at cellular membranes and link other viral components to the matrix–membrane complex resulting in individual particle shapes ...
Joanna Timmins, R. Ruigrok, W. Weissenhorn   +2 more
semanticscholar   +1 more source

Full-length three-dimensional structure of the influenza A virus M1 protein and its organization into a matrix layer

PLoS Biology, 2020
Matrix proteins are encoded by many enveloped viruses, including influenza viruses, herpes viruses, and coronaviruses. Underneath the viral envelope of influenza virus, matrix protein 1 (M1) forms an oligomeric layer critical for particle stability and ...
Lisa Selzer, Z. Su, G. Pintilie, W. Chiu, K. Kirkegaard   +4 more
semanticscholar   +1 more source