Results 121 to 130 of about 664,008 (371)
A novel biclustering approach to association rule mining for predicting HIV-1-human protein interactions. [PDF]
PLoS ONE, 2012 Identification of potential viral-host protein interactions is a vital and useful approach towards development of new drugs targeting those interactions.
Anirban Mukhopadhyay +2 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source
Retroviral matrix proteins: a structural perspective.
Virology, 1998 Retroviral assembly is a crucial process in the late stage of the virus life cycle, based on the ability of the Gag proteins to direct the formation of virion-like particles (for reviews see Wills and Craven, 1991; Hunter, 1994).
M. Conte, S. Matthews
semanticscholar +1 more source
Dynein Regulators Are Important for Ecotropic Murine Leukemia Virus Infection [PDF]
, 2016 Indexación: Web of Science.During the early steps of infection, retroviruses must direct the movement of the viral genome into the nucleus to complete their replication cycle.
Arriagada, Gloria +4 more
core +1 more source
Advanced Functional Materials, EarlyView.This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley +1 more source
Protein intrinsic disorder toolbox for comparative analysis of viral proteins
BMC Genomics, 2008 To examine the usefulness of protein disorder predictions as a tool for the comparative analysis of viral proteins, a relational database has been constructed. The database includes proteins from influenza A and HIV-related viruses.
Uversky Vladimir N +2 more
doaj +1 more source
HIV-1 Virus-like Particle Budding Assay
Bio-Protocol, 2013 Viral replication culminates with the egress of the mature virion from the host cell. This step of the viral life cycle has recently garnered increased attention with the discovery of the cellular restriction factor, Tetherin, which tethers budded ...
Nathan Vande Burgt +2 more
doaj +1 more source
Polarization restricts hepatitis C virus entry into HepG2 hepatoma cells [PDF]
, 2009 The primary reservoir for hepatitis C virus (HCV) replication is believed to be hepatocytes, which are highly polarized with tight junctions (TJ) separating their basolateral and apical domains.
Balfe, Peter +8 more
core +3 more sources
Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks
Advanced Functional Materials, EarlyView.This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson +12 more
wiley +1 more source
Rhabdovirus matrix protein structures reveal a novel mode of self-association.
PLoS Pathogens, 2008 The matrix (M) proteins of rhabdoviruses are multifunctional proteins essential for virus maturation and budding that also regulate the expression of viral and host proteins. We have solved the structures of M from the vesicular stomatitis virus serotype
Stephen C Graham +9 more
doaj +1 more source