Results 141 to 150 of about 664,008 (371)

Ubiquitin-Regulated Nuclear-Cytoplasmic Trafficking of the Nipah Virus Matrix Protein Is Important for Viral Budding

PLoS Pathogens, 2010
Paramyxoviruses are known to replicate in the cytoplasm and bud from the plasma membrane. Matrix is the major structural protein in paramyxoviruses that mediates viral assembly and budding. Curiously, the matrix proteins of a few paramyxoviruses have been found in the nucleus, although the biological function associated with this nuclear localization ...
Michael P. Lake, Yao E. Wang, Alexander N. Freiberg, Arnold Park, Michael Wolf, Benhur Lee, Tatyana Yun, Michael R. Holbrook, Michael R. Holbrook, Mickey Pentecost, Betsabe Torres   +10 more
openaire   +5 more sources

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Entropic forces drive clustering and spatial localization of influenza A M2 during viral budding

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance For influenza virus to release from the infected host cell, controlled viral budding must finalize with membrane scission of the viral envelope.
Jesper J. Madsen, John M. A. Grime, J. Rossman, G. Voth   +3 more
semanticscholar   +1 more source

Interaction of silver nanoparticles with HIV-1 [PDF]

, 2005
The interaction of nanoparticles with biomolecules and microorganisms is an expanding field of research. Within this field, an area that has been largely unexplored is the interaction of metal nanoparticles with viruses. In this work, we demonstrate that
Burt, Justin L, Camacho-Bragado, Alejandra, Elechiguerra, Jose Luis, Gao, Xiaoxia, Lara, Humberto H, Morones, Jose R, Yacaman, Miguel Jose   +6 more
core   +3 more sources

Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications

Advanced Healthcare Materials, EarlyView.
Nanomaterial integration transforms biosensor capabilities through enhanced signal transduction, sensitivity, and selectivity. This review analyzes how nanoscale materials—from nanoparticles to nanosheets—leverage unique physicochemical properties to revolutionize electrochemical, optical, and electrical biosensing.
Younghak Cho, Yunyoung Choi, Yerim Jang, Hyejeong Seong   +3 more
wiley   +1 more source

In silico exploration of deep-sea fungal metabolites as inhibitor of Ebola and Marburg VP35 and VP40.

PLoS ONE
VP30 and VP40 proteins of Ebola and Marburg viruses have been recognized as potential targets for antiviral drug development due to their essential roles in the viral lifecycle.
Abdullah R Alanzi, Mohammed F Alajmi, Mohammed S Al-Dosari, Mohammad K Parvez, Moneerah J Alqahtani   +4 more
doaj   +1 more source

The Effects of Viral Structural Proteins on Acidic Phospholipids in Host Membranes

Viruses
Enveloped viruses rely on host membranes for trafficking and assembly. A substantial body of literature published over the years supports the involvement of cellular membrane lipids in the enveloped virus assembly processes.
Ricardo de Souza Cardoso, Akira Ono
doaj   +1 more source

Matrix-M™ adjuvant enhances immunogenicity of both protein- and modified vaccinia virus Ankara-based influenza vaccines in mice

Immunologic research, 2018
Influenza viruses continuously circulate in the human population and escape recognition by virus neutralizing antibodies induced by prior infection or vaccination through accumulation of mutations in the surface proteins hemagglutinin (HA) and ...
S. Magnusson, Arwen F Altenburg, K. Bengtsson, F. Bosman, R. D. de Vries, G. Rimmelzwaan, Linda Stertman   +6 more
semanticscholar   +1 more source

Papilloomiviiruse transkriptsiooni ja regulaatorvalgu E2 uurimine [PDF]

, 2018
Väitekirja elektrooniline versioon ei sisalda publikatsioonePapilloomiviirused on viiruste perekond, mis nakatab nii inimeste kui loomade epiteelrakke ja põhjustab papilloome ehk näsakasvajaid, mis võivad teatud tingimustes areneda halvaloomulisteks ...
Sankovski, Eve
core  

In silico screening of sugar alcohol compounds to inhibit viral matrix protein VP40 of Ebola virus

Molecular Biology Reports, 2019
Ebola virus is a virulent pathogen that causes highly lethal hemorrhagic fever in human and non-human species. The rapid growth of this virus infection has made the scenario increasingly complicated to control the disease. Receptor viral matrix protein (VP40) is highly responsible for the replication and budding of progeny virus.
Nagasundaram Nagarajan, Edward K. Y. Yapp, Nguyen Quoc Khanh Le, Hui-Yuan Yeh   +3 more
openaire   +4 more sources