The Interactions of Viral Matrix Proteins with Membranes [PDF]
Matrix proteins form the main structure of an enveloped virus, connecting the nucleocapsid to the phospholipid membrane. We have studied the M1 proteins from HRSV and Influenza A to determine their structural characteristics and the nature of their lipid binding.
Jim Freeth+2 more
semanticscholar +3 more sources
Restriction of Viral Replication by Mutation of the Influenza Virus Matrix Protein [PDF]
ABSTRACT The matrix protein (M1) of influenza virus plays an essential role in viral assembly and has a variety of functions, including association with influenza virus ribonucleoprotein (RNP). Our previous studies show that the association of M1 with viral RNA and nucleoprotein not only promotes formation of helical RNP but also is required ...
Teresa Liu, Zhiping Ye
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The Human Respiratory Syncytial Virus Matrix Protein Is Required for Maturation of Viral Filaments [PDF]
ABSTRACT An experimental system was developed to generate infectious human respiratory syncytial virus (HRSV) lacking matrix (M) protein expression (M-null virus) from cDNA. The role of the M protein in virus assembly was then examined by infecting HEp-2 and Vero cells with the M-null virus and assessing the impact on infectious virus ...
Ruchira Mitra+4 more
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Mechanisms of phosphatidylserine influence on viral production: A computational model of Ebola virus matrix protein assembly [PDF]
AbstractEbola virus (EBOV) infections continue to pose a global public health threat, with high mortality rates and sporadic outbreaks in Central and Western Africa. A quantitative understanding of the key processes driving EBOV assembly and budding could provide valuable insights to inform drug development.
Xiao Liu+5 more
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Efficient SIVcpz replication in human lymphoid tissue requires viral matrix protein adaptation [PDF]
SIVs infecting wild-living apes in west central Africa have crossed the species barrier to humans on at least four different occasions, one of which spawned the AIDS pandemic. Although the chimpanzee precursor of pandemic HIV-1 strains must have been able to infect humans, the capacity of SIVcpz strains to replicate in human lymphoid tissues (HLTs) is ...
Frédéric Bibollet‐Ruche+9 more
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Ebola virus (EBOV) causes severe hemorrhagic fevers in humans and non-human primates. While the role of the EBOV major matrix protein VP40 in morphogenesis is well understood, nothing is known about its contributions to the regulation of viral genome replication and/or transcription.
T. Hoenen+4 more
semanticscholar +4 more sources
Purified matrix protein of vesicular stomatitis virus blocks viral transcription in vitro. [PDF]
One of the major structural proteins of vesicular stomatitis virus is a small, nonglycosylated, matrix protein which associates with the nucleocapsid core during final stages of morphogenesis and budding. Biochemical and genetic studies suggested that the matrix protein regulates RNA synthesis both in vitro and in vivo.
Bishnu P. De+3 more
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The formation of influenza virus ribonucleoprotein (RNP) is a necessary step in viral assembly and maturation in infected cells, but the mechanism remains incompletely understood. Influenza virus proteins such as matrix (M1) and cellular proteins have been implicated in assembly and transport of RNP.
Xiaoyuan Huang+4 more
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Role of Viral Hemorrhagic Septicemia Virus Matrix (M) Protein in Suppressing Host Transcription [PDF]
ABSTRACT Viral hemorrhagic septicemia virus (VHSV) is a pathogenic fish rhabdovirus found in discrete locales throughout the Northern Hemisphere. VHSV infection of fish cells leads to upregulation of the host's virus detection response, but the virus quickly suppresses interferon (IFN) production and antiviral gene expression.
Ke Qi+11 more
+8 more sources
Intracellular Behavior of Rabies Virus Matrix Protein (M) Is Determined by the Viral Glycoprotein (G) [PDF]
AbstractTo investigate the nature and intracellular behavior of the matrix (M) protein of an avirulent strain (HEP‐Flury) of rabies virus, we cloned and sequenced the cDNA of the protein. Using expression vectors pZIP‐NeoSV(X)1 and pCDM8, the cDNA was transfected to animal cells (BHK‐21 and COS‐7) with or without coexpression of viral glycoprotein (G).
Koichiro Nakahara+6 more
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