Results 11 to 20 of about 259,105 (298)

Vesicular Stomatitis Virus Matrix Protein Mutations That Affect Association with Host Membranes and Viral Nucleocapsids [PDF]

Journal of Biological Chemistry, 2008
Viral matrix (M) proteins bind the nucleoprotein core (nucleocapsid) to host membranes during the process of virus assembly by budding. Previous studies using truncated M proteins had implicated the N-terminal 50 amino acids of the vesicular stomatitis virus M protein in binding both membranes and nucleocapsids and a sequence from amino acids 75-106 as
Brooke A. Dancho, Margie O. McKenzie, John H. Connor, Douglas S. Lyles   +3 more
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Efficient HIV-1 replication can occur in the absence of the viral matrix protein [PDF]

The EMBO Journal, 1998
Matrix (MA), a major structural protein of retroviruses, is thought to play a critical role in several steps of the HIV-1 replication cycle, including the plasma membrane targeting of Gag, the incorporation of envelope (Env) glycoproteins into nascent particles, and the nuclear import of the viral genome in non-dividing cells.
Heide Reil
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ROLE OF HOST CELL GLYCOLYTIC PROTEINS; ALPHA ENOLASE AND PYRUVATE KINASE IN INFLUENZA A VIRUS INFECTED CELLS

International Journal of Infectious Diseases, 2023
Intro: Influenza A virus, a respiratory pathogen known to manipulate various cellular metabolic processes including glycolysis. Our earlier studies demonstrated the interaction of influenza A viral structural proteins; nucleoprotein and matrix protein ...
P. Goyal, M.S. Rajala
doaj   +1 more source

The Cytoplasmic Tail of Influenza A Virus Hemagglutinin and Membrane Lipid Composition Change the Mode of M1 Protein Association with the Lipid Bilayer

Membranes, 2021
Influenza A virus envelope contains lipid molecules of the host cell and three integral viral proteins: major hemagglutinin, neuraminidase, and minor M2 protein.
Larisa V. Kordyukova, Petr V. Konarev, Nataliya V. Fedorova, Eleonora V. Shtykova, Alexander L. Ksenofontov, Nikita A. Loshkarev, Lubov A. Dadinova, Tatyana A. Timofeeva, Sergei S. Abramchuk, Andrei V. Moiseenko, Lyudmila A. Baratova, Dmitri I. Svergun, Oleg V. Batishchev   +12 more
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Computational Drug Design against Ebola Virus Targeting Viral Matrix Protein VP30

Borneo Journal of Pharmacy, 2019
Ebola viral disease (EVD) is a deadly infectious hemorrhagic viral fever caused by the Ebola virus with a high mortality rate. Until date, there is no effective drug or vaccination available to combat this condition. This study focuses on designing an effective antiviral drug for Ebola viral disease targeting viral protein 30 (VP30) of Ebola virus ...
Arthi Venkatesan, Lavanya Ravichandran, J. Febin Prabhu Dass   +2 more
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The Matrix Protein of a Plant Rhabdovirus Mediates Superinfection Exclusion by Inhibiting Viral Transcription [PDF]

Journal of Virology, 2019
Superinfection exclusion (SIE) is a widespread phenomenon in which an established virus infection prevents reinfection by closely related viruses. Understanding the mechanisms governing SIE will not only advance our basic knowledge of virus infection cycles but may also lead to improved design of antiviral measures. Despite the significance of SIE, our
Xin Zhou, Kai Sun, Xueping Zhou, Andrew O. Jackson, Zhenghe Li   +4 more
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A Calcium-Fortified Viral Matrix Protein [PDF]

Structure, 2014
In this issue of Structure, Leyrat and colleagues provide the first structural analysis of the human metapneumovirus (HMPV) matrix protein, a key regulator of viral assembly. Though structurally similar to other matrix proteins, two calcium binding sites suggest intriguing differences in regulation.
Amarasinghe, Gaya K., Dutch, Rebecca Ellis   +1 more
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Purified matrix protein of vesicular stomatitis virus blocks viral transcription in vitro. [PDF]

Proceedings of the National Academy of Sciences, 1982
One of the major structural proteins of vesicular stomatitis virus is a small, nonglycosylated, matrix protein which associates with the nucleocapsid core during final stages of morphogenesis and budding. Biochemical and genetic studies suggested that the matrix protein regulates RNA synthesis both in vitro and in vivo.
Bishnu P. De, George B. Thornton, Daniel Luk, A K Banerjee   +3 more
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Mechanisms of phosphatidylserine influence on viral production: A computational model of Ebola virus matrix protein assembly [PDF]

Journal of Biological Chemistry, 2022
AbstractEbola virus (EBOV) infections continue to pose a global public health threat, with high mortality rates and sporadic outbreaks in Central and Western Africa. A quantitative understanding of the key processes driving EBOV assembly and budding could provide valuable insights to inform drug development.
Xiao Liu, Ethan J. Pappas, Monica L. Husby, Balindile B. Motsa, Robert V. Stahelin, Elsje Pienaar   +5 more
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The Deoptimization of Rabies Virus Matrix Protein Impacts Viral Transcription and Replication [PDF]

Viruses, 2019
Rabies virus (RABV) matrix (M) protein plays several important roles during RABV infection. Although previous studies have assessed the functions of M through gene rearrangements, this interferes with the position of other viral proteins. In this study, we attenuated M expression through deoptimizing its codon usage based on codon pair bias in RABV ...
Jun Luo, Yue Zhang, Qiong Zhang, Yuting Wu, Boyue Zhang, Meijun Mo, Qin Tian, Jing Zhao, Mingzhu Mei, Xiaofeng Guo   +9 more
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