Results 21 to 30 of about 259,105 (298)

Matrix protein Osteonectin (SPARC) reduces inflammation and mortality during viral myocarditis [PDF]

European Heart Journal, 2013
Rationale: Acute viral myocarditis (VM) is one of the leading causes of heart failure in young adults, lacking specific therapy. Osteonection (SPARC) is a non-structural matrix protein modulating cell-matrix interaction in the heart, and has been implicated in cardiac remodeling.
M. Rienks, D. Vanhoutte, J. Van Teeffelen, P. Carai, B. Eskens, A. Papageorgiou, S. Heymans   +6 more
openaire   +1 more source

Efficient SIVcpz replication in human lymphoid tissue requires viral matrix protein adaptation [PDF]

Journal of Clinical Investigation, 2012
SIVs infecting wild-living apes in west central Africa have crossed the species barrier to humans on at least four different occasions, one of which spawned the AIDS pandemic. Although the chimpanzee precursor of pandemic HIV-1 strains must have been able to infect humans, the capacity of SIVcpz strains to replicate in human lymphoid tissues (HLTs) is ...
Frédéric Bibollet‐Ruche, Anke Heigele, Brandon F. Keele, Juliet Easlick, Julie M. Decker, Jun Takehisa, Gerald H. Learn, Paul M. Sharp, Beatrice H. Hahn, Frank Kirchhoff   +9 more
openalex   +5 more sources

ANP32B is a nuclear target of henipavirus M proteins. [PDF]

PLoS ONE, 2014
Membrane envelopment and budding of negative strand RNA viruses (NSVs) is mainly driven by viral matrix proteins (M). In addition, several M proteins are also known to be involved in host cell manipulation.
Anja Bauer, Sebastian Neumann, Axel Karger, Ann-Kristin Henning, Andrea Maisner, Boris Lamp, Erik Dietzel, Linda Kwasnitschka, Anne Balkema-Buschmann, Günther M Keil, Stefan Finke   +10 more
doaj   +1 more source

The Matrix Protein of Vesicular Stomatitis Virus Binds Dynamin for Efficient Viral Assembly [PDF]

Journal of Virology, 2010
ABSTRACT Matrix proteins (M) direct the process of assembly and budding of viruses belonging to the Mononegavirales order. Using the two-hybrid system, the amino-terminal part of vesicular stomatitis virus (VSV) M was shown to interact with dynamin pleckstrin homology domain. This interaction was confirmed
Hélène, Raux, Linda, Obiang, Nicolas, Richard, Francis, Harper, Danielle, Blondel, Yves, Gaudin   +5 more
openaire   +2 more sources

Role of Viral Hemorrhagic Septicemia Virus Matrix (M) Protein in Suppressing Host Transcription [PDF]

Journal of Virology, 2017
ABSTRACT Viral hemorrhagic septicemia virus (VHSV) is a pathogenic fish rhabdovirus found in discrete locales throughout the Northern Hemisphere. VHSV infection of fish cells leads to upregulation of the host's virus detection response, but the virus quickly suppresses interferon (IFN) production and antiviral gene expression.
Ke, Qi, Weaver, Wade, Pore, Adam, Gorgoglione, Bartolomeo, Wildschutte, Julia H., Xiao, Peng, Shepherd, Brian S., Spear, Allyn, Malathi, Krishnamurthy, Stepien, Carol A., Vakharia, Vikram N., Leaman, Douglas W.   +11 more
openaire   +3 more sources

The Ebola Virus Matrix Protein VP40 Interacts With Several Host Protein Networks to Facilitate Viral Replication [PDF]

Current Clinical Microbiology Reports, 2015
The Ebola virus (EBOV) is a lipid-enveloped virus that is filamentous in shape and belongs to the Filoviridae family. EBOV can cause viral hemorrhagic fever in humans and non-human primates with high rates of fatality. Using a negative sense RNA genome that encodes just eight proteins, the lipid-enveloped EBOV can enter mammalian cells and undergo ...
Cary T. Frick, Robert V. Stahelin
openalex   +2 more sources

The Ebola virus matrix protein clusters phosphatidylserine, a critical step in viral budding [PDF]

, 2021
AbstractPhosphatidylserine (PS) has been shown to be a critical lipid factor in the assembly and spread of numerous lipid enveloped viruses. Here, we describe the ability of the Ebola virus (EBOV) matrix protein eVP40 to induce clustering of PS and promote viral budding in vitro, as well as the ability of an FDA approved drug, fendiline, to reduce PS ...
Monica L. Husby, Souad Amiar, Laura I. Prugar, Emily A. David, Caroline B. Plescia, Kathleen E. Huie, Jennifer M. Brannan, John M. Dye, Elsje Pienaar, Robert V. Stahelin   +9 more
openaire   +1 more source

Nuclear export of influenza viral ribonucleoprotein is temperature-dependently inhibited by dissociation of viral matrix protein

Virology, 2003
The influenza virus copies its genomic RNA in the nuclei of host cells, but the viral particles are formed at the plasma membrane. Thus, the export of new genome from the nucleus into the cytoplasm is essential for viral production. Several viral proteins, such as nucleoprotein (NP) and RNA polymerases, synthesized in the cytoplasm, are imported into ...
Sakaguchi, Atsushi, Hirayama, Etsuko, Hiraki, Akihiro, Ishida, Y.o-ichi, Kim, Jeman   +4 more
openaire   +2 more sources

Influenza viral matrix 1 protein aggravates viral pathogenicity by inducing TLR4-mediated reactive oxygen species production and apoptotic cell death

Cell Death & Disease, 2023
AbstractInfluenza virus is one of the most challenging viruses threating human health. Since infection with influenza virus triggers inflammatory responses and induces cell death, the molecular and cellular mechanisms by which the virus-infected cells undergo apoptotic and necrotic cell death have been widely studied.
Chang-Ung Kim, Dahwan Lim, Young Sang Kim, Bonsu Ku, Doo-Jin Kim   +4 more
openaire   +3 more sources

Cell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function

Nature Communications, 2022
Matriglycan, a repeating disaccharide on α-dystroglycan, is the receptor for Lassa virus and specific extracellular matrix proteins. Here, the authors demonstrate that matriglycan, in a length-dependent tunable manner, is both necessary and sufficient ...
M. Osman Sheikh, Chantelle J. Capicciotti, Lin Liu, Jeremy Praissman, Dahai Ding, Daniel G. Mead, Melinda A. Brindley, Tobias Willer, Kevin P. Campbell, Kelley W. Moremen, Lance Wells, Geert-Jan Boons   +11 more
doaj   +1 more source