Results 31 to 40 of about 664,008 (371)

Nipah shell disorder, modes of infection, and virulence [PDF]

, 2020
The Nipah Virus (NiV) was first isolated during a 1998–9 outbreak in Malaysia. The outbreak initially infected farm pigs and then moved to humans from pigs with a case-fatality rate (CFR) of about 40%.
Dunker, A. Keith, Foster, James A., Goh, Gerard Kian-Meng, Uversky, Vladimir N.   +3 more
core   +1 more source

Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization

Science Advances, 2022
Measles virus, Nipah virus, and multiple other paramyxoviruses cause disease outbreaks in humans and animals worldwide. The paramyxovirus matrix (M) protein mediates virion assembly and budding from host cell membranes.
M. Norris, Monica L Husby, W. Kiosses, J. Yin, Roopashi Saxena, L. Rennick, Anja Heiner, S. Harkins, R. Pokhrel, S. Schendel, K. Hastie, S. Landeras-Bueno, Z. L. Salie, Benhur Lee, P. Chapagain, A. Maisner, W. Duprex, R. Stahelin, E. Saphire   +18 more
semanticscholar   +1 more source

Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding

EMBO reports, 2022
Phosphatidylserine (PS) is a critical lipid factor in the assembly and spread of numerous lipid-enveloped viruses. Here, we describe the ability of the Ebola virus (EBOV) matrix protein eVP40 to induce clustering of PS and promote viral budding in vitro, as well as the ability of an FDA-approved drug, fendiline, to reduce PS clustering and subsequent ...
Monica L Husby, Souad Amiar, Laura I Prugar, Emily A David, Caroline B Plescia, Kathleen E Huie, Jennifer M Brannan, John M Dye, Elsje Pienaar, Robert V Stahelin   +9 more
openaire   +2 more sources

Heparan Sulfate Proteoglycans in Viral Infection and Treatment: A Special Focus on SARS-CoV-2

International Journal of Molecular Sciences, 2021
Heparan sulfate proteoglycans (HSPGs) encompass a group of glycoproteins composed of unbranched negatively charged heparan sulfate (HS) chains covalently attached to a core protein.
V. De Pasquale, Miriam Shasa Quiccione, S. Tafuri, L. Avallone, L. Pavone   +4 more
semanticscholar   +1 more source

Association of Influenza Virus Matrix Protein with Ribonucleoproteins May Control Viral Growth and Morphology

Virology, 2002
The matrix protein (M1) of influenza virus plays a central role in viral replication. In relation to viral growth and morphology, we studied the RNP-binding activity of M1s from high-growth strain A/Puerto Rico/8/34 (A/PR8/34) and the relatively low-growth wild-type strain A/Nanchang/933/95.
Teresa Liu, Jacqueline Müller, Zhiping Ye   +2 more
openalex   +4 more sources

The Matrix Protein of Vesicular Stomatitis Virus Binds Dynamin for Efficient Viral Assembly [PDF]

Journal of Virology, 2010
ABSTRACT Matrix proteins (M) direct the process of assembly and budding of viruses belonging to the Mononegavirales order. Using the two-hybrid system, the amino-terminal part of vesicular stomatitis virus (VSV) M was shown to interact with dynamin pleckstrin homology domain. This interaction was confirmed
Danielle Blondel, Francis Harper, Nicolas Richard, Yves Gaudin, Hélène Raux, Linda Obiang   +5 more
openaire   +3 more sources

Understanding Viral Transmission Behavior via Protein Intrinsic Disorder Prediction: Coronaviruses [PDF]

, 2012
Besides being a common threat to farm animals and poultry, coronavirus (CoV) was responsible for the human severe acute respiratory syndrome (SARS) epidemic in 2002-4. However, many aspects of CoV behavior, including modes of its transmission, are yet to
Dunker, A. Keith, Goh, Gerard Kian-Meng, Uversky, Vladmir N.   +2 more
core   +3 more sources

Applying antibodies inside cells: Principles and recent advances in neurobiology, virology and oncology [PDF]

, 2020
To interfere with cell function, many scientists rely on methods that target DNA or RNA due to the ease with which they can be applied. Proteins are usually the final executors of function but are targeted only indirectly by these methods.
Marschall, Andrea, Mejias, Rebeca, Roewe, Julian, Zhang, Congcong, Ötjengerdes, Rina M.   +4 more
core   +1 more source

Intracellular Transport of HIV-1 Matrix Protein Associated with Viral RNA

World Journal of AIDS, 2013
HIV-1 matrix protein (MA) is a multifunctional structural protein localized on N terminus of Gag precursor p55. MA participates in HIV-1 assembly as membranotropic part of Gag precursor as well as an individual protein spliced from Gag early in infection. MA is found in the nuclei of infected cells and in plasma membrane, the site of virus assembly, in
А. І. Гоженко, Valentina Divocha, Galina K. Vorkunova, A. G. Bukrinskaya, Sergey I. Lupandin   +4 more
openalex   +4 more sources

Cell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function

Nature Communications, 2022
Matriglycan, a repeating disaccharide on α-dystroglycan, is the receptor for Lassa virus and specific extracellular matrix proteins. Here, the authors demonstrate that matriglycan, in a length-dependent tunable manner, is both necessary and sufficient ...
M. Osman Sheikh, Chantelle J. Capicciotti, Lin Liu, Jeremy Praissman, Dahai Ding, Daniel G. Mead, Melinda A. Brindley, Tobias Willer, Kevin P. Campbell, Kelley W. Moremen, Lance Wells, Geert-Jan Boons   +11 more
doaj   +1 more source