Results 51 to 60 of about 259,105 (298)

Subunit interactions of vesicular stomatitis virus envelope glycoprotein stabilized by binding to viral matrix protein [PDF]

Journal of Virology, 1992
The mechanism by which viral glycoproteins are incorporated into virus envelopes during budding from host membranes is a major question of virus assembly. Evidence is presented here that the envelope glycoprotein (G protein) of vesicular stomatitis virus binds to the viral matrix protein (M protein) in vitro with the specificity, reversibility, and ...
D S, Lyles, M, McKenzie, J W, Parce
openaire   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

NEDD4 family ubiquitin ligases associate with LCMV Z's PPXY domain and are required for virus budding, but not via direct ubiquitination of Z.

PLoS Pathogens, 2019
Viral late domains are used by many viruses to recruit the cellular endosomal sorting complex required for transport (ESCRT) to mediate membrane scission during viral budding.
Christopher M Ziegler, Loan Dang, Philip Eisenhauer, Jamie A Kelly, Benjamin R King, Joseph P Klaus, Inessa Manuelyan, Ethan B Mattice, David J Shirley, Marion E Weir, Emily A Bruce, Bryan A Ballif, Jason Botten   +12 more
doaj   +1 more source

A model system for antiviral siRNA therapeutics using exosome-based delivery

Molecular Therapy: Nucleic Acids, 2022
Emerging viral diseases, such as Ebola, SARS, MERS, and the pathogen causing COVID-19, SARS-CoV-2, present a challenge for the development of therapeutics because of strict biosafety handling procedures and rapid mutation of their genomes.
Margaret Wallen, Farrukh Aqil, Raghuram Kandimalla, Jeyaprakash Jeyabalan, Supipi Auwardt, Neha Tyagi, David J. Schultz, Wendy Spencer, Ramesh C. Gupta   +8 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Ciliated epithelial cell differentiation at air–liquid interface and respiratory syncytial virus infection using animal-free media and substrates

ERJ Open Research
Background Animal-derived components in cell culture, such as fetal bovine serum and extracellular matrix proteins, pose ethical concerns and contribute to variability in experimental outcomes.
Machaela Palor, Elizabeth K. Haughey, Jenny Herbert, Christopher O'Callaghan, Rosalind L. Smyth, Paolo De Coppi, Robert E. Hynds, Claire M. Smith   +7 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

HIV-1 Structural Proteins or Cell-Signaling Factors? That Is the Question!

Current Issues in Molecular Biology
The biological activity of structural HIV-1 proteins is not limited to ensuring a productive viral infection but also interferes with cellular homeostasis through intra- and extracellular signaling activation.
Michele Pellegrino, Francesca Giordano, Francesca De Amicis, Maria Marra, Paola Tucci, Stefania Marsico, Stefano Aquaro   +6 more
doaj   +1 more source

Obtaining and Immunologic Characterization of Filoviruses Recombinant Proteins VP40 and NP

Проблемы особо опасных инфекций, 2010
Full-size genes coding matrix proteins VP40 of Ebola virus (VE) and Marburg virus (VM) and nucleoprotein (NP) of VE were cloned. These genes expression in Escherichia coli and purification of their products by affinity chromatography using Ni-NTA agarose
A. V. Ivanova, E. I. Kazachinskaya, A. V. Kachko, E. L. Subbotina, A. V. Sorokin, I. A. Razumov, S. V. Neteosov, V. B. Loktev   +7 more
doaj   +1 more source

Association of Influenza Virus Matrix Protein with Ribonucleoproteins May Control Viral Growth and Morphology

Virology, 2002
The matrix protein (M1) of influenza virus plays a central role in viral replication. In relation to viral growth and morphology, we studied the RNP-binding activity of M1s from high-growth strain A/Puerto Rico/8/34 (A/PR8/34) and the relatively low-growth wild-type strain A/Nanchang/933/95.
Liu, Teresa, Muller, Jacqueline, Ye, Zhiping   +2 more
openaire   +2 more sources