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Microbiology Spectrum, 2023 The pathogenicity of a virus to a specific host species is an inerratic and describable ability of a virus to cause infection but is generally shaped by a variety of abiotic and biotic factors.
Huan Yu +6 more
doaj +1 more source
Host and Viral Proteins Modulating Ebola and Marburg Virus Egress
Viruses, 2019 The filoviruses Ebolavirus and Marburgvirus are among the deadliest viral pathogens known to infect humans, causing emerging diseases with fatality rates of up to 90% during some outbreaks.
T. Gordon +4 more
semanticscholar +1 more source
Minimum energy paths for conformational changes of viral capsids [PDF]
, 2017 In this work we study how a viral capsid can change conformation using techniques of Large Deviations Theory for stochastic differential equations. The viral capsid is a model of a complex system in which many units - the proteins forming the capsomers -
Cermelli, Paolo +2 more
core +2 more sources
The Ebola virus matrix protein clusters phosphatidylserine, a critical step in viral budding [PDF]
, 2021 AbstractPhosphatidylserine (PS) has been shown to be a critical lipid factor in the assembly and spread of numerous lipid enveloped viruses. Here, we describe the ability of the Ebola virus (EBOV) matrix protein eVP40 to induce clustering of PS and promote viral budding in vitro, as well as the ability of an FDA approved drug, fendiline, to reduce PS ...
Kathleen E. Huie +9 more
openaire +2 more sources
Scientific Reports, 2017 Polyhedra can encapsulate other proteins and have potential applications as protein stabilizers. The extremely stable polyhedra matrix may provide a platform for future engineered micro-crystal devices.
Zhong-Jian Guo +6 more
doaj +1 more source
Veterinary Research, 2019 Nuclear localization of paramyxovirus proteins is crucial for virus life cycle, including the regulation of viral replication and the evasion of host immunity.
Zhiqiang Duan +5 more
semanticscholar +1 more source
Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]
, 2014 The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis +1 more
core +4 more sources
Journal of General Virology, 1994 The matrix (M) protein is viewed as the regulator of paramyxovirus particle assembly and budding. Accordingly it was observed to be mutated, and/or decreased in amount, in cases where virus particle production was significantly reduced. Here, a non-productive [non-defective and defective interfering (DI)] Sendai virus infection of COS cells is ...
Geneviève Mottet +2 more
openaire +3 more sources
Influenza virus morphogenesis and budding. [PDF]
, 2009 Influenza viruses are enveloped, negative stranded, segmented RNA viruses belonging to Orthomyxoviridae family. Each virion consists of three major sub-viral components, namely (i) a viral envelope decorated with three transmembrane proteins ...
Balogun, Rilwan A +4 more
core +1 more source
Chicken bromodomain-containing protein 2 interacts with the Newcastle disease virus matrix protein and promotes viral replication [PDF]
Veterinary Research, 2020 AbstractBromodomain-containing protein 2 (BRD2) is a nucleus-localized serine-threonine kinase that plays pivotal roles in the transcriptional control of diverse genes. In our previous study, the chicken BRD2 (chBRD2) protein was found to interact with the Newcastle disease virus (NDV) matrix (M) protein using a yeast two-hybrid screening system, but ...
Duan, Zhiqiang +7 more
openaire +5 more sources