Results 71 to 80 of about 664,008 (371)

The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress

Scientific Reports, 2016
VP40 is one of eight proteins encoded by the Ebola Virus (EBOV) and serves as the primary matrix protein, forming virus like particles (VLPs) from mammalian cells without the need for other EBOV proteins.
Kristen A. Johnson, G. Taghon, Jordan L. Scott, R. Stahelin   +3 more
semanticscholar   +1 more source

AAVR-Displaying Interfaces: Serotype-Independent Adeno-Associated Virus Capture and Local Delivery Systems. [PDF]

, 2019
Interfacing gene delivery vehicles with biomaterials has the potential to play a key role in diversifying gene transfer capabilities, including localized, patterned, and controlled delivery. However, strategies for modifying biomaterials to interact with
Cho, Mira, Jang, Jae-Hyung, Kim, Seung-Hyun, Lee, Heehyung, Lee, Slgirim, Schaffer, David V   +5 more
core   +1 more source

Matrix proteins as centralized organizers of negative-sense RNA virions.

Frontiers in Bioscience, 2013
Matrix proteins are essential components of most negative-sense RNA, enveloped viruses. They serve a wide range of duties ranging from self-driven membrane budding and coordination of other viral components to modulation of viral transcription.
Lassi J Liljeroos, S. Butcher
semanticscholar   +1 more source

Helical ordering of envelope‐associated proteins and glycoproteins in respiratory syncytial virus

EMBO Journal, 2021
Human respiratory syncytial virus (RSV) causes severe respiratory illness in children and the elderly. Here, using cryogenic electron microscopy and tomography combined with computational image analysis and three‐dimensional reconstruction, we show that ...
M. Conley, Judith M. Short, Andrew M. Burns, J. Streetley, J. Hutchings, Saskia E Bakker, B. J. Power, Hussain Jaffery, Joanne Haney, G. Zanetti, P. Murcia, M. Stewart, R. Fearns, Swetha Vijayakrishnan, D. Bhella   +14 more
semanticscholar   +1 more source

Breakthrough Solution for Antimicrobial Resistance Detection: Surface‐Enhanced Raman Spectroscopy‐based on Artificial Intelligence

Advanced Materials Interfaces, EarlyView., 2023
This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi, Munevver Akdeniz, Awel Olsido Ahmed, Mine Altunbek, Omer Aydin   +4 more
wiley   +1 more source

Function, Architecture, and Biogenesis of Reovirus Replication Neoorganelles

Viruses, 2019
Most viruses that replicate in the cytoplasm of host cells form neoorganelles that serve as sites of viral genome replication and particle assembly. These highly specialized structures concentrate viral proteins and nucleic acids, prevent the activation ...
Raquel Tenorio, Isabel Fernández de Castro, Jonathan J. Knowlton, Paula F. Zamora, Danica M. Sutherland, Cristina Risco, Terence S. Dermody   +6 more
doaj   +1 more source

Deep sequencing of protease inhibitor resistant HIV patient isolates reveals patterns of correlated mutations in Gag and protease. [PDF]

PLoS Computational Biology, 2015
While the role of drug resistance mutations in HIV protease has been studied comprehensively, mutations in its substrate, Gag, have not been extensively cataloged.
William F Flynn, Max W Chang, Zhiqiang Tan, Glenn Oliveira, Jinyun Yuan, Jason F Okulicz, Bruce E Torbett, Ronald M Levy   +7 more
doaj   +1 more source

Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias?

Viruses, 2019
Heparan sulfate proteoglycans (HSPG) are composed of unbranched, negatively charged heparan sulfate (HS) polysaccharides attached to a variety of cell surface or extracellular matrix proteins.
V. Cagno, E. Tseligka, Samuel T. Jones, C. Tapparel   +3 more
semanticscholar   +1 more source

Anticancer Gene Transfer for Cancer Gene Therapy [PDF]

, 2014
Gene therapy vectors are among the treatments currently used to treat malignant tumors. Gene therapy vectors use a specific therapeutic transgene that causes death in cancer cells.
A Aiuti, A Aiuti, A Biffi, A Winkeler, AD Bucheit, AW Tong, B Everts, B Kaur, B Moss, B Vogelstein, BR Dix, C Alvarez-Breckenridge, C Heise, C Schliemann, C Springfeld, CC O’Shea, CE Gomez, CE Thomas, CJ Sherr, CM Lai, D Hanahan, D Meirow, D Moroziewicz, D Piwnica-Worms, DF Stojdl, DR Koehler, DR Koehler, E Kelly, EJ Boviatsis, F Simonelli, FJ Morling, GD Trobridge, HA Hoster, HD Klenk, HH Wong, I Friedrich, J Ansari, J Chou, J Cinatl Jr, J Clarke, J Foloppe, J Fueyo, J Hardcastle, J Jin, J Sinkovics, J Veerapong, JA Noser, JC Deutekom van, JM Bergelson, JM Markert, JN Harada, JR Bischoff, JW Bainbridge, K Boztug, K Hamada, K Iguchi, K Nakano, KD Smith, KW Peng, KW Peng, KW Peng, KW Reichard, KX Zhang, L Chen, L Yuan, M Ahonen, M Bergmann, M Chase, M Egeblad, M Kinali, M Sauane, MA Kay, MA Passini, MA Stoff-Khalili, ML Lamfers, MS Ferguson, N Cartier, N Cartier, N Natarajan, N Nayerossadat, NK Green, NL Fox, O Hallgren, O Meier, OG Donnelly, P Msaouel, P Msaouel, PA Lewitt, PG Spear, Q Wu, R Cattaneo, R Cattaneo, R Stripecke, R Waehler, RM Lorence, S Aggarwal, S Chalikonda, S Cirak, S Goverdhana, S Grimm, S Inoue, S Jones, S Kumar, S Nagano, S Suzuki, SA Vorburger, SK Pal, T Flotte, T Gianni, T Kuroda, T Mineta, T Muster, T Sasaki, T Todo, T Todo, T Todo, TC Doyle, TG Huang, WW Spurbeck, X Wang, Y Yi, YY Mahller, Z Peng, Z Zhang, ZS Guo, ZS Guo   +125 more
core   +1 more source

Preparation of nuclear matrices from cultured cells: subfractionation of nuclei in situ [PDF]

, 1984
Analyses of the different structural systems of the nucleus and the proteins associated with them pose many problems. Because these systems are largely overlapping, in situ localization studies that preserve the in vivo location of proteins and cellular ...
Deppert, Wolfgang, Staufenbiel, Matthias
core   +2 more sources