Results 141 to 150 of about 830,992 (283)

Immune Checkpoint Inhibitor‐Associated Myocarditis With Myositis/Myasthenia Gravis Overlap Syndrome: Two Case Reports Highlighting Early Onset, Diagnostic Uncertainty, and Management Considerations

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Custom illustration created by the author in collaboration with the Mayo Clinic Digital Media Department. ABSTRACT Immune checkpoint‐inhibitors (ICIs) have revolutionized and significantly improved cancer care through remarkable efficacy, but significant adverse effects have been observed.
Artur Schneider, Nikita Jhawar, Deepica Reddy, Razvan Chirila   +3 more
wiley   +1 more source

Coxsackievirus B3 Infection Induced Viral Myocarditis by Regulating the Expression Pattern of Chemokines in Cardiac Myocytes

Iranian Journal of Allergy, Asthma and Immunology, 2009
Viral myocarditis is a common cardiovascular disease, which has greatly threatened human health. However, up to now, the pathogenesis of viral myocarditis has been unclear, which leads to the lack of its effective treatments.
Shen Yan, Cheng Kan Quan, Wei Chu Yi, Dong Xiong Si   +3 more
doaj  

The immunoproteasome‐specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis

EMBO Molecular Medicine, 2018
Severe heart pathology upon virus infection is closely associated with the immunological equipment of the host. Since there is no specific treatment available, current research focuses on identifying new drug targets to positively modulate predisposing ...
N. Althof, Carl Christoph Goetzke, Meike Kespohl, K. Voss, A. Heuser, S. Pinkert, Z. Kaya, K. Klingel, A. Beling   +8 more
semanticscholar   +1 more source

Early Onset Heart Failure due to RBM20 Variant: A Case Report Emphasizing Genetic Diagnosis and Arrhythmic Risk Stratification

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Transthoracic echocardiography demonstrating biventricular dilatation. Parasternal long‐ and short‐axis views and apical four‐ and two‐chamber views show marked left ventricular dilatation with increased end‐diastolic volume, associated with right ventricular dilatation.
Cristian Orlando Porras Bueno, Cesar Augusto Balaguera, Alejandro Mariño Correa, Edward Andrés Cáceres Méndez   +3 more
wiley   +1 more source

The cholinergic anti-inflammatory pathway ameliorates acute viral myocarditis in mice by regulating CD4+ T cell differentiation

Virulence, 2018
Many studies have found that abnormalities in the proportion and differentiation of CD4+ T cells (Th cells) are closely related to the pathogenesis of viral myocarditis (VMC). Our previous research indicates that the cholinergic anti-inflammatory pathway
De-Pu Zhou, Li-sha Ge, Guangwu Chen, Xiaohong Gu, Xing Chao, Zheng Cheng, Wenwen Zhang, Li Jia, Jiajin Lin, M. Chu, Yue-chun Li   +10 more
semanticscholar   +1 more source

Retrospective Case Series of Fulminant Metabolic Crisis in GSDIA: Persistent Lactic Acidosis Despite Correction of Hypoglycemia May Reflect Secondary Mitochondrial Dysfunction

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Although several advances in glycogen storage disorder (GSD) management have been made over the years, there is still increased morbidity and mortality in these patients, particularly among those with GSD type I (GSDI). Here, we describe a case series of five patients with GSDIa who presented with severe lactic acidosis and passed away without
Herodes Guzman, Nicole Stewart, Lauren Mitteer, Victoria Sanders, Rebecca Ganetzky, Diva D. De Leon   +5 more
wiley   +1 more source

THE EVOLUTION OF UNDERSTANDING OF THE IMMUNE SYSTEM'S ROLE IN THE PATHOGENESIS OF INFLAMMATORY MYOCARDIAL DISEASES: TH17-MEDIATED IMMUNE MECHANISMS

Кубанский научный медицинский вестник, 2014
The review article discusses recent advances in our understanding of viral myocarditis such as pathogenic role of infection and immune mechanisms in acute, sub-acute and chronic phases of the disease.
N. R. Paleev, P. N. Paleev, E. I. Ostrovsky, V. I. Karandashov, N. P. Sanina, N. N. Khishova, O. V. Moskalets, A. P. Linnik, A. N. Makarkov   +8 more
doaj  

Longitudinal Monitoring of Systemic Cytokines After Mild Zika Virus Infection Revealed an Association Between Th17 Polarization and Clinical and Serological Outcomes

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Zika virus (ZIKV) is a neurotropic virus that can cause a variety of neurological manifestations, ranging from mild forms to severe disorders like Guillain–Barré syndrome and congenital Zika syndrome. The pathophysiology of these complications is not fully understood, but they have been linked to host immune responses, particularly a ...
Solène Marquine, Marie Mura, Franck de Laval, Gilda Grard, Cyril Badaut, Sébastien Briolant, Aurélie Trignol   +6 more
wiley   +1 more source

Peptidomics in Different Phases of Severe Acute Pancreatitis Model

PROTEOMICS – Clinical Applications, Volume 20, Issue 1, January 2026.
ABSTRACT Severe acute pancreatitis (SAP) involves dynamic shifts from inflammation to immunosuppression, where peptidomic profile evolution may reveal prognostic biomarkers. Here, the plasma peptidome of rats with taurocholate‐induced SAP at 1, 3, 6, 12, and 24 h compared with controls was characterized using nLC‐MS/MS.
Roberto Rasslan, Marcia Kiyomi Koike, Marcel Cerqueira Cesar Machado, Luiz Felipe Martucci, Leo Kei Iwai, Rosangela Aparecida dos Santos Eichler, Edivaldo Massazo Utiyama, Emer Suavinho Ferro, Edna Frasson de Souza Montero   +8 more
wiley   +1 more source

Case Report: Three cases of clinically suspected viral myocarditis with recovery of left ventricular dysfunction

Frontiers in Cardiovascular Medicine
Viral myocarditis is an important cause of non-ischemic cardiomyopathy. Multiple clinical manifestations have been reported, including acute heart failure, cardiogenic shock, and ventricular arrhythmias.
Jonathan Brown, Hytham Rashid, Siva T. Sarva, Suhas Tatapudi, Jeby Kalathoor, Aswin Srinivasan, Michael Daniel, Syed Raza   +7 more
doaj   +1 more source