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Viral pathogenesis: Unlocking Ebola persistence
Nature Microbiology, 2017The 2013–2016 West African Ebola virus outbreak evidenced that the virus can persist in survivors long-term, leading to sequelae and risks of new transmission chains. Ebola virus has now been shown to behave similarly in rhesus macaques, enabling their use to study persistence and intervention strategies.
Trina, Racine, Gary P, Kobinger
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Pathogenesis of viral hepatitis
Baillière's Clinical Gastroenterology, 1990Over the past few years there has been increasing understanding of the pathogenesis of viral hepatitis. This review will be confined to hepatitis B and will not consider other viruses affecting the liver, such as cytomegalovirus, herpesvirus and the Epstein Barr virus.
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2021
In biliary atresia (BA), extrahepatic bile ducts are initially affected and extrahepatic biliary obstruction causes cholestasis, a decrease in bile flow, leading to subsequent liver damage and a progressive loss of intrahepatic bile ducts. As speculated etiology of BA, although several viruses have been detected in the liver and biliary remnants in ...
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In biliary atresia (BA), extrahepatic bile ducts are initially affected and extrahepatic biliary obstruction causes cholestasis, a decrease in bile flow, leading to subsequent liver damage and a progressive loss of intrahepatic bile ducts. As speculated etiology of BA, although several viruses have been detected in the liver and biliary remnants in ...
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IMMUNOBIOLOGY AND PATHOGENESIS OF VIRAL HEPATITIS
Annual Review of Pathology: Mechanisms of Disease, 2006Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV) and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause persistent infection, cirrhosis, and liver cancer. HBV and HCV are noncytopathic viruses and, thus, immunologically mediated events play an important role in the pathogenesis and ...
GUIDOTTI, LUCA, Chisari FV
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Pathogenesis of viral hemorrhagic fever
Current Opinion in Immunology, 2005Single-stranded RNA viruses from four different families cause a syndrome of fever and malaise, 'capillary leak' with loss of plasma volume, and coagulation defects which can lead to bleeding. Although direct cytopathic effects can contribute to disease severity, most features of illness are caused by innate immune responses, as the systemic spread of ...
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Proteomic Dissection of Viral Pathogenesis
2008Many factors play into the complexity of viral pathogenesis. Understanding viral pathogenesis is key to developing vaccines and treatments for viral diseases. One emerging area of research is proteomics, which is the study of the protein complement and functions of the genome.
H C, Liu, J, Hicks, D, Yoo
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Molecular pathogenesis of viral hepatitis
Journal of Gastroenterology and Hepatology, 2000Abstract The global burden of chronic liver disease caused by persistent infection with hepatitis B and C viruses has meant the urgent development of therapeutic strategies designed to control active replication and therefore prevent subsequent clinical sequelae.
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Pathogenesis of viral hepatitis.
Journal of biological regulators and homeostatic agents, 2003The aim of our research is to use animal models to elucidate the molecular basis for viral clearance and liver disease in the pathogenesis of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. The results herein discussed provide insight into immunological and virological processes that may lead to the development of new therapeutic ...
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Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract
Nature Reviews Microbiology, 2021David F Boyd +2 more
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