Results 251 to 260 of about 572,658 (301)

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Natural evidence of coronaviral 2'-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding. [PDF]

Signal Transduct Target Ther
Deng J, Yang S, Li Y, Tan X, Liu J, Yu Y, Ding Q, Fan C, Wang H, Chen X, Liu Q, Guo X, Gong F, Zhou L, Chen Y.   +14 more
europepmc   +1 more source

Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1

Cytoskeleton, EarlyView.
ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

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Fibronectin and Viral Pathogenesis

Clinical Infectious Diseases, 1987
Fibronectin is a dimeric high-molecular-weight glycoprotein composed of two similar but not identical subunits. Differences have been observed between plasma and cell-derived fibronectins, and molecular and sequencing studies have revealed a domain structure.
J, Keski-Oja, A, Hautanen, I, Julkunen
openaire   +2 more sources

Ferreting out viral pathogenesis

Nature Microbiology, 2019
Severe fever with thrombocytopenia virus is an emerging, highly lethal tick-borne pathogen with growing impact. In this issue of Nature Microbiology, two papers make major progress towards a better understanding of its so far incompletely understood mechanisms of virulence.
Jennifer Deborah, Wuerth, Friedemann, Weber   +1 more
openaire   +2 more sources

Editorial overview: Viral pathogenesis

Current Opinion in Virology, 2015
Viral pathogenesis studies the mechanisms whereby a virus causes disease. More broadly, however, viral pathogenesis encompasses all the processes that occur when a virus infects a host, independently of whether disease is induced or not. Indeed, the process of infection is of interest per se, regardless of disease outcome.
Guidotti, Luca G., Iannacone, Matteo
openaire   +2 more sources

Cytokine-induced viral purging — role in viral pathogenesis

Current Opinion in Microbiology, 1999
The control of viral infections was previously thought to rely exclusive ly on the antigen-specific destruction of infected cells by the antigen-specific destruction of infected cells by the immune system; however, recent studies have shown that several viral infections can be primarily controlled by noncytopathic, cytokine- dependent 'curative ...
GUIDOTTI, LUCA, Chisari FV
openaire   +3 more sources

Pathogenesis of Viral Lymphomas

2008
Epstein-Barr virus (EBV), Kaposi’s sarcoma herpesvirus (KSHV), also called Human Herpesvirus 8 (HHV-8), and human T-cell lymphotrophic virus (HTLV-1) are viruses that are well documented to be causally associated with lymphoid neoplasia in humans. Other viruses have also been proposed to be involved in lymphomagenesis, but their role may be indirect ...
Ethel, Cesarman, Enrique A, Mesri
openaire   +2 more sources

HIV heterogeneity and viral pathogenesis

AIDS, 1988
HIV research in the past year has elucidated many questions relevant to strategies for treatment and control. For instance, there is a greater understanding of the diversity of HIV isolates as well as the wide range of potential cells sensitive to infection.
B A, Castro, C, Cheng-Mayer, L A, Evans, J A, Levy   +3 more
openaire   +2 more sources