Results 101 to 110 of about 928,330 (381)
Molecular Oncology, EarlyView.PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang +6 more
wiley +1 more source
Viral self-assembly as a thermodynamic process [PDF]
Phys. Rev. Lett. 90, 248101 (2003), 2002 The protein shells, or capsids, of all sphere-like viruses adopt icosahedral symmetry. In the present paper we propose a statistical thermodynamic model for viral self-assembly. We find that icosahedral symmetry is not expected for viral capsids constructed from structurally identical protein subunits and that this symmetry requires (at least) two ...
arxiv +1 more source
Viruses, 2019 Mayaro (MAYV) and Una (UNAV) are emerging arboviruses belonging to the Alphavirus genus of the Togaviridae family. These viruses can produce febrile disease with symptoms such as fever, headache, myalgia, skin rash and incapacitating poly-arthralgia ...
Yessica Y. Llamas-González +4 more
doaj +1 more source
Discerning the relationship between geminiviral infection and vesicle trafficking using virus induced gene silencing [PDF]
, 2017 Tomato yellow leaf curl disease is one of the most important threats to tomato crops worldwide. One of its causal agents, Tomato yellow leaf curl Sardinian virus (TYLCSV) is a monopartite member of the genus Begomovirus from the family Geminiviridae. Due
Cana-Quijada, Pepe +3 more
core
Viral Aspects of Protein Phosphorylation
Journal of General Virology, 1988 The discovery that the protein encoded by the transforming gene of Rous sarcoma virus (RSV) has protein kinase activity (Collett & Erikson, 1978) brought the subject of protein phosphorylation to the general attention of virologists. Retrovirus protein kinases have been extensively reviewed (e.g.
David P. Leader, Matilda Katan
openaire +3 more sources
Molecular Oncology, EarlyView.High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive type of ovarian cancer with urgent need for new treatment strategies. This study evaluates plasma‐activated media (PAM) as a novel treatment for HGSOC, showing its ability to selectively induce oxidative stress and apoptosis in HGSOC cell lines, patient ascites cells and primary
Lorena T. Davies +9 more
wiley +1 more source
The Spanning Tree Model and the Assembly Kinetics of RNA Viruses [PDF]
arXiv, 2021 Single-stranded (ss) RNA viruses self-assemble spontaneously in solutions that contain the viral RNA genome molecules and the viral capsid proteins. The self-assembly of empty capsids can be understood on the basis of free energy minimization of rather simple models.
arxiv
Papilomavirus y cáncer de cérvix Papillomavirus in cervical carcinoma
Revista Colombiana de Obstetricia y Ginecología, 2003 La infección por el papilomavirus humano (pvh), es la enfermedad de transmisión sexual más común en el mundo. El pvh es causa necesaria para el desarrollo de cáncer de cérvix, pero no es suficiente ya que otros factores están involucrados en la ...
Hernán Cortés Yepes
doaj
Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP [PDF]
, 2008 Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell.
Bienkowska-Szewczyk, Krystyna +19 more
core
Non-viral approaches to gene therapy [PDF]
, 1993 Several advances in non-viral gene transfer technology have been reported over the past year. Cationic lipids have been successfully used to deliver genes in vivo, providing a clear alternative to recombinant viruses.
Behr +44 more
core +1 more source