Results 171 to 180 of about 928,330 (381)

Identification of antiviral roles for the exon-junction complex and nonsense-mediated decay in flaviviral infection. [PDF]

, 2019
West Nile virus (WNV) is an emerging mosquito-borne flavivirus, related to dengue virus and Zika virus. To gain insight into host pathways involved in WNV infection, we performed a systematic affinity-tag purification mass spectrometry (APMS) study to ...
Cherry, Sara, Dittmar, Mark, Jang, Gwendolyn M, Johnson, Jeffrey R, Kim, Grace, Krogan, Nevan J, Li, Minghua, Newton, Billy W, Ramage, Holly, Shah, Priya S, Truong, Billy, Von Dollen, John, Weinbren, Nathan   +12 more
core  

Viral protein synthesis in Friend erythroleukemia cell lines [PDF]

, 1977
Janis Racevskis, Gebhard Koch
openalex   +1 more source

Enhancing transporter activity in heterologous expression systems with SAHA: a 2500‐times more potent and odorless alternative to butyrate

FEBS Open Bio, EarlyView.
Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel, Maurice Tust, Samira Boussettaoui, Dietmar Fischer, Dirk Gründemann   +4 more
wiley   +1 more source

KEGG tools for classification and analysis of viral proteins. [PDF]

Protein Sci, 2023
Jin Z, Sato Y, Kawashima M, Kanehisa M.
europepmc   +1 more source

Icosahedral packing of RNA viral genomes [PDF]

arXiv, 2003
Recent studies reveal that certain viruses package a portion of their genome in a manner that mirrors the icosahedral symmetry of the protein container, or capsid. Graph theoretical constraints forbid exact realization of icosahedral symmetry. This paper proposes a model for the determination of quasi-icosahedral genome structures and discusses the ...
arxiv  

Structural Virology: The Key Determinants in Development of Antiviral Therapeutics

Viruses
Structural virology has emerged as the foundation for the development of effective antiviral therapeutics. It is pivotal in providing crucial insights into the three-dimensional frame of viruses and viral proteins at atomic-level or near-atomic-level ...
Tanuj Handa, Ankita Saha, Aarthi Narayanan, Elsa Ronzier, Pravindra Kumar, Jitin Singla, Shailly Tomar   +6 more
doaj   +1 more source

Tomato marchitez virus, a new plant picorna-like virus from tomato related to tomato torrado virus [PDF]

A new virus was isolated from a tomato plant from the state of Sinaloa in Mexico. This plant showed symptoms locally known as `marchitez disease¿: severe leaf necrosis, beginning at the base of the leaflets, and necrotic rings on the fruits.
Dullemans, A.M., Heuvel, J.F.J.M., van den, Maris, P.C., Verbeek, M., Vlugt, R.A.A., van der   +4 more
core   +2 more sources

Studies of Simian Sarcoma and Simian Sarcoma-Associated Virus: I. Analysis of Viral Structural Proteins, and Preparation and Characterization of Antiserum Specific for Viral Envelope Components [PDF]

, 1978
F Deinhardt, Carolyn M. Bergholz, Gerhard Hunsmann, Josef Schneider, H. Thiel, Werner Schäfer, Hartmut Beug   +6 more
openalex   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Predicting sub-population specific viral evolution [PDF]

arXiv
Forecasting the change in the distribution of viral variants is crucial for therapeutic design and disease surveillance. This task poses significant modeling challenges due to the sharp differences in virus distributions across sub-populations (e.g., countries) and their dynamic interactions.
arxiv