Results 221 to 230 of about 1,214,456 (357)

An m⁶A methyltransferase confers host resistance by degrading viral proteins through ubiquitination. [PDF]

Nat Commun
Guo J, Zhang T, Xie H, Hu H, Shi C, Zhao Y, Yin J, Xu G, Wu Z, Wang P, Liu J, Liu P, Zhong K, Chen F, Chen J, Yang J.   +15 more
europepmc   +1 more source

The potato mop-top virus TGB2 protein and viral RNA associate with chloroplasts and viral infection induces inclusions in the plastids [PDF]

, 2012
Graham H. Cowan, Alison G. Roberts, Sean Chapman, Angelika Ziegler, Eugene I. Savenkov, L. Torrance   +5 more
openalex   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Evolution of BA.2.86 to JN.1 reveals that functional changes in non-structural viral proteins are required for fitness of SARS-CoV-2. [PDF]

J Virol
Tsujino S, Tsuda M, Nao N, Okumura K, Wang L, Oda Y, Mimura Y, Li J, Hashimoto R, Matsumura Y, Suzuki R, Suzuki S, Yoshimatsu K, Nagao M, Ito J, Takayama K, Sato K, Matsuno K, Tamura T, Tanaka S, Fukuhara T, Genotype to Phenotype Japan (G2P-Japan) Consortium.   +21 more
europepmc   +1 more source

Current research on viral proteins that interact with fibrillarin. [PDF]

Mol Biol Rep, 2023
Decle-Carrasco S, Rodríguez-Piña AL, Rodríguez-Zapata LC, Castano E.   +3 more
europepmc   +1 more source

4D Mapping of ZIF Biocomposites for High Protein Loading and Tunable Release Profiles

Advanced Functional Materials, EarlyView.
Systematic four‐dimensional mapping of zeolitic imidazolate framework biocomposites reveals how precursor ratios, total concentration, and washing define crystalline phase, protein loading, and release kinetics. This comprehensive study identifies conditions yielding record loading (∼85%) and precise phase–property correlations.
Michael R. Hafner, Francesco Carraro, Behnaz Abbasgholi‐NA, Simone Dal Zilio, Max Schmallegger, Helmar Wiltsche, Lingcong Ge, Michael R. Reithofer, Efwita Astria, Laura Villanova, Heinz Amenitsch, Christian Doonan, Paolo Falcaro   +12 more
wiley   +1 more source

Beyond Infection: The Role of Secreted Viral Proteins in Pathogenesis, Disease Severity and Diagnostic Applications. [PDF]

Cells
Herrera-Moro Huitron L, Cruz-Holguin VJ, Ulloa-Aguilar JM, De Jesús-González LA, Osuna-Ramos JF, Guzmán-Huerta M, de León-Bautista MP, León-Reyes G, García-Cordero J, Cedillo-Barrón L, Cerna-Cortes JF, León-Juárez M.   +11 more
europepmc   +1 more source

Data from A Viral Vaccine Encoding Prostate-Specific Antigen Induces Antigen Spreading to a Common Set of Self-Proteins in Prostate Cancer Patients

, 2023
Nancy J. Nesslinger, Alvin Wei Tian Ng, Kwong-Yok Tsang, Theresa Ferrara, Jeffrey Schlom, James L. Gulley, Brad H. Nelson   +6 more
openalex   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

In-silico study of approved drugs as potential inhibitors against 3CLpro and other viral proteins of CoVID-19. [PDF]

PLoS One
Aqeel I, Majid A, Alahmadi TJ, Althubaity A.   +3 more
europepmc   +1 more source