Results 11 to 20 of about 38,667 (276)

HIV Antibody Fc N-Linked Glycosylation Is Associated with Viral Rebound [PDF]

Cell Reports, 2020
Summary: Changes in antibody glycosylation are linked to inflammation across several diseases. Alterations in bulk antibody galactosylation can predict rheumatic flares, act as a sensor for immune activation, predict gastric cancer relapse, track with ...
Rasmus Offersen, Wen-Han Yu, Eileen P. Scully, Boris Julg, Zelda Euler, Saheli Sadanand, Dario Garcia-Dominguez, Lu Zheng, Thomas A. Rasmussen, Madeleine F. Jennewein, Caitlyn Linde, Jessica Sassic, Giuseppe Lofano, Selena Vigano, Kathryn E. Stephenson, Stephanie Fischinger, Todd J. Suscovich, Mathias Lichterfeld, Douglas Lauffenburger, Erik S. Rosenberg, Todd Allen, Marcus Altfeld, Richelle C. Charles, Lars Østergaard, Martin Tolstrup, Dan H. Barouch, Ole S. Søgaard, Galit Alter   +27 more
doaj   +4 more sources

Symptom and Viral Rebound in Untreated SARS-CoV-2 Infection. [PDF]

Ann Intern Med, 2023
Although symptom and viral rebound have been reported after nirmatrelvir-ritonavir treatment, the trajectories of symptoms and viral load during the natural course of COVID-19 have not been well described.To characterize symptom and viral rebound in untreated outpatients with mild to moderate COVID-19.Retrospective analysis of participants in a ...
Deo R, Choudhary MC, Moser C, Ritz J, Daar ES, Wohl DA, Greninger AL, Eron JJ, Currier JS, Hughes MD, Smith DM, Chew KW, Li JZ, ACTIV-2/A5401 Study Team.   +13 more
europepmc   +6 more sources

Vesicular MicroRNA as Potential Biomarkers of Viral Rebound. [PDF]

Cells, 2022
Changes in the cellular microRNA (miRNA) expression profile in response to HIV infection, replication or latency have been reported. Nevertheless, little is known concerning the abundance of miRNA in extracellular vesicles (EVs). In the search for a reliable predictor of viral rebound, we quantified the amount of miR-29a, miR-146a, and miR-155 in two ...
Bazié WW, Boucher J, Traoré IT, Kania D, Somé DY, Alary M, Gilbert C.   +6 more
europepmc   +5 more sources

Viral Rebound Kinetics Correlate with Distinct HIV Antibody Features. [PDF]

mBio, 2021
Plasma viremia reoccurs in most HIV-infected individuals once antiretroviral therapy is interrupted, and interindividual differences in the kinetics of viral rebound have been associated with virological and immunological factors. Antibody features, including Fc functionality and Fc glycosylation, have been identified as sensitive surrogates for ...
Bartsch YC, Loos C, Rossignol E, Fajnzylber JM, Yuan D, Avihingsanon A, Ubolyam S, Jupimai T, Hirschel B, Ananworanich J, Lauffenburger DA, Li JZ, Alter G, Julg B.   +13 more
europepmc   +5 more sources

Time to Viral Rebound After Interruption of Modern Antiretroviral Therapies. [PDF]

Clin Infect Dis, 2022
AbstractBackgroundDevelopment of human immunodeficiency virus (HIV) remission strategies requires precise information on time to HIV rebound after treatment interruption, but there is uncertainty regarding whether modern antiretroviral therapy (ART) regimens and timing of ART initiation may affect this outcome.MethodsAIDS Clinical Trials Group (ACTG ...
Li JZ, Aga E, Bosch RJ, Pilkinton M, Kroon E, MacLaren L, Keefer M, Fox L, Barr L, Acosta E, Ananworanich J, Coombs R, Mellors JW, Landay AL, Macatangay B, Deeks S, Gandhi RT, Smith DM.   +17 more
europepmc   +6 more sources

Soluble markers of viral rebound and post-treatment HIV control. [PDF]

Curr Opin HIV AIDS
Purpose of review We focus on the different classes of biological molecules measurable in easily accessible bodily fluids that have the potential to serve as biomarkers for the HIV post-treatment controller (PTC) phenotype and/or the timing of viral rebound after stopping antiretroviral therapy (ART).
Giron LB, Pasternak AO, Abdel-Mohsen M.
europepmc   +5 more sources

Detecting Sources of Immune Activation and Viral Rebound in HIV Infection. [PDF]

J Virol, 2022
AbstractAntiretroviral therapy (ART) generally suppresses HIV replication to undetectable levels in peripheral blood, but immune activation associated with increased morbidity and mortality is sustained during ART, and infection rebounds when treatment is interrupted.
Wietgrefe SW, Duan L, Anderson J, Marqués G, Sanders M, Cummins NW, Badley AD, Dobrowolski C, Karn J, Pagliuzza A, Chomont N, Sannier G, Dubé M, Kaufmann DE, Zuck P, Wu G, Howell BJ, Reilly C, Herschhorn A, Schacker TW, Haase AT.   +20 more
europepmc   +3 more sources

Incidence of Viral Rebound After Treatment With Nirmatrelvir-Ritonavir and Molnupiravir.

JAMA Netw Open, 2022
ImportanceSome patients treated with nirmatrelvir-ritonavir have experienced rebound of COVID-19 infections and symptoms; however, data are scarce on whether viral rebound also occurs in patients with COVID-19 receiving or not receiving molnupiravir.ObjectiveTo examine the incidence of viral rebound in patients with COVID-19 who were treated with the ...
Wong GL, Yip TC, Lai MS, Wong VW, Hui DS, Lui GC.   +5 more
europepmc   +3 more sources

Viral Rebound Among Persons With Diagnosed HIV Who Achieved Viral Suppression, United States. [PDF]

J Acquir Immune Defic Syndr, 2020
Background: Some persons who achieve viral suppression may later experience viral rebound, potentially putting them at risk for transmitting HIV. We estimate the prevalence of, and describe factors associated with, viral rebound among adults with diagnosed HIV in the United States who had ≥2 viral load tests in a 12-month ...
Craw JA, Beer L, Tie Y, Jaenicke T, Shouse RL, Prejean J.   +5 more
europepmc   +4 more sources

Resurgence of HIV infection among men who have sex with men in Switzerland : mathematical modelling study [PDF]

, 2012
New HIV infections in men who have sex with men (MSM) have increased in Switzerland since 2000 despite combination antiretroviral therapy (cART). The objectives of this mathematical modelling study were: to describe the dynamics of the HIV epidemic in ...
Bezemer, Daniela, Bucher, Heiner C., de Wolf, Frank, Derendinger, Steven, Fraser, Christophe, Gebhardt, Martin, Glass, Tracy R., Jeannin, André, Low, Nicola, Swiss HIV, Cohort Study, van Sighem, Ard, Vernazza, Pietro, Vidondo, Beatriz   +12 more
core   +17 more sources