Results 31 to 40 of about 606,321 (264)

Viral dynamics during structured treatment interruptions of chronic human immunodeficiency virus type 1 infection [PDF]

, 2002
Although antiviral agents which block human immunodeficiency virus (HIV) replication can result in long-term suppression of viral loads to undetectable levels in plasma, long-term therapy fails to eradicate virus, which generally rebounds after a single ...
Ruiz, L, Javier Martinez-Picado, Clotet, B, Frost, SDW, Martinez-Picado, J, Lidia Ruiz, Leigh Brown, AJ, Simon D. W. Frost, Bonaventura Clotet, Andrew J. Leigh Brown   +9 more
core   +1 more source

A comparison between abacavir and efavirenz as the third drug used in combination with a background therapy regimen of 2 nucleoside reverse-transcriptase inhibitors in patients with initially suppressed viral loads [PDF]

, 2006
Background. Our objective was to compare the rate of viral rebound and therapy failure in patients receiving abacavir or efavirenz as the third drug ( in addition to 2 non-abacavir nucleosides) in combination antiretroviral therapy ( cART) and to compare
Phillips, AN, L. Sighinolfi, D'ARMINIO MONFORTE A, R. Cauda, MOIOLI MC, Monforte, AD, COZZI-LEPRI A, DI GIAMBENEDETTO S, M. Mena, Sighinolfi, L, SIGHINOLFI L, A. Cozzi Lepri, Lichtner, M, ICoNA Study Group, Arlotti, M, M. Lichtner, Bongiovanni, M, Mena, M, M. Arlotti, UCSC Roma HIV Cohort Study Group, CAUDA R, A. N. Phillips, De Luca, A, Di Giambenedetto, S, Cozzi-Lepri, A, DE LUCA A, BONGIOVANNI M, PHILLIPS AN, UCSC-Roma HIV Cohort Study Grp, Narciso, P, Cauda, R, IMIT Study Grp, IMIT Study Group, A. De Luca, ICoNA Study Grp, MENA M, ARLOTTI M, NARCISO P, LICHTNER M, M. C. Moioli, Moioli, MC, S. Di Giambenedetto, P. Narciso, M. Bongiovanni, A. d’Arminio Monforte   +44 more
core   +1 more source

Immunotherapy with DNA vaccine and live attenuated rubella/SIV gag vectors plus early ART can prevent SIVmac251 viral rebound in acutely infected rhesus macaques.

PLoS ONE, 2020
Anti-retroviral therapy (ART) has been highly successful in controlling HIV replication, reducing viral burden, and preventing both progression to AIDS and viral transmission. Yet, ART alone cannot cure the infection.
Konstantin Virnik, Margherita Rosati, Alexei Medvedev, Aaron Scanlan, Gabrielle Walsh, Frances Dayton, Kate E Broderick, Mark Lewis, Yvonne Bryson, Jeffrey D Lifson, Ruth M Ruprecht, Barbara K Felber, Ira Berkower   +12 more
doaj   +1 more source

Analytical Treatment Interruption after Short-Term Antiretroviral Therapy in a Postnatally Simian-Human Immunodeficiency Virus-Infected Infant Rhesus Macaque Model

mBio, 2019
To achieve long-term viral remission in human immunodeficiency virus (HIV)-infected children, novel strategies beyond early antiretroviral therapy (ART) will be necessary. Identifying clinical predictors of the time to viral rebound upon ART interruption
Ria Goswami, Ashley N. Nelson, Joshua J. Tu, Maria Dennis, Liqi Feng, Amit Kumar, Jesse Mangold, Riley J. Mangan, Cameron Mattingly, Alan D. Curtis, Veronica Obregon-Perko, Maud Mavigner, Justin Pollara, George M. Shaw, Katharine J. Bar, Ann Chahroudi, Kristina De Paris, Cliburn Chan, Koen K. A. Van Rompay, Sallie R. Permar   +19 more
doaj   +1 more source

Viral suppression and viral rebound among young adults living with HIV in Canada

Medicine, 2018
Describe the prevalence and covariates of viral suppression and subsequent rebound among younger (≤29 years old) compared with older adults.A retrospective clinical cohort study; eligibility criteria: documented HIV infection; resident of Canada; 18 years and over; first antiretroviral regimen comprised of at least 3 individual agents on or after ...
Palmer, Alexis, Gabler, Karyn, Rachlis, Beth, Ding, Erin, Chia, Jason, Bacani, Nic, Bayoumi, Ahmed M., Closson, Kalysha, Klein, Marina, Cooper, Curtis, Burchell, Ann, Walmsley, Sharon, Kaida, Angela, Hogg, Robert   +13 more
openaire   +2 more sources

Identifying correlates of viral rebound timing and viral control in SHIV-infected infant macaques after ART interruption. [PDF]

Sci Transl Med
Evaluation of HIV cure strategies requires antiretroviral therapy (ART) interruption, but ethical and clinical considerations make this difficult in children. Here, we used a pediatric preclinical model of simian-HIV (SHIV) infection to uncover features associated with time to viral rebound (TTR) and posttreatment control (PTC) of ...
Obregon-Perko V, Awasthi A, Barfield R, Berendam SJ, Yagnik B, Styles T, Tharp G, Gupta PM, Mensah G, Neja M, Kumar M, Fray E, Bu F, Pollara J, Tuyishime M, Ferrari G, Siliciano JD, Siliciano RF, Mavigner M, Silvestri G, Amara RR, Bosinger S, Fouda GG, Permar SR, Chan C, Chahroudi A.   +25 more
europepmc   +4 more sources

A multidimensional HIV-1 persistence model for clonal expansion and viral rebound in vitro. [PDF]

Cell Rep Methods, 2021
Using a replication-competent virus for prolonged in vitro culture, Matsuda et al. captured the heterogenous HIV-1 genome and integration site landscape, examined viral cytopathic effects and clonal expansion capacity, and tested drugs that can eliminate HIV-1-infected cells.
Eshetu A, Ho YC.
europepmc   +3 more sources

Quantitative analysis of viral persistence and transient viral load rebound from HIV clinical data [PDF]

2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011
Highly active antiretroviral therapy (HAART) suppresses HIV RNA viral load below the limit of detection for many patients. However, clinical data demonstrates that the HIV virus is not eradicated by HAART, even in patients who have had no detectable virus for 7 years [1].
Rutao Luo, Michael J. Piovoso, Ryan Zurakowski   +2 more
openaire   +2 more sources

Potential biomarkers: Predicting post-treatment viral rebound in rhesus macaques

Cell Reports Medicine, 2023
In this issue of Cell Reports Medicine, Aid and colleagues define peripheral blood biomarkers, which predict viral rebound after antiretroviral therapy (ART) discontinuation in SIV-infected rhesus macaques treated early with ART, providing insights into potential HIV cure strategies.1.
Yang, Chenbo, Xue, Jing
openaire   +2 more sources

Factors associated with viral suppression and rebound among adult HIV patients on treatment: a retrospective study in Ghana

AIDS Research and Therapy, 2022
Background Viral suppression remains the most desired outcome in the management of patients with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) and this can be achieved by an effective Antiretroviral Therapy (ART).
Stephen Opoku, Samuel Asamoah Sakyi, Nana Kwame Ayisi-Boateng, Anthony Kwame Enimil, Ebenezer Senu, Richard Owusu Ansah, Bismark Dankwah Aning, Diana Atsieno Ojuang, Doreen Nafula Wekesa, Fatima Osman Ahmed, Chidinma B. Okeke, Ama Darkoaa Sarfo   +11 more
doaj   +1 more source