Symptom and Viral Rebound in Untreated SARS-CoV-2 Infection. [PDF]
Ann Intern Med, 2023 BACKGROUND: Although symptom and viral rebound have been reported after nirmatrelvir-ritonavir treatment, the trajectories of symptoms and viral load during the natural course of COVID-19 have not been well described.
Deo R +13 more
europepmc +9 more sources
A theory for viral rebound after antiviral treatment: A study case for SARS-CoV-2 [PDF]
Mathematical BiosciencesA fraction of individuals infected with SARS-CoV-2 experienced rebounds when treated with effective antivirals such as Nirmatrelvir/Ritonavir (Paxlovid). Although this phenomenon has been studied from biological and statistical perspectives, the underlying dynamical mechanism is not yet fully understood.
Ignacio Sanchez +2 more
exaly +7 more sources
Plasma HIV viral rebound following protocol-indicated cessation of ART commenced in primary and chronic HIV infection. [PDF]
PLoS ONE, 2012 ObjectivesThe magnitude of HIV viral rebound following ART cessation has consequences for clinical outcome and onward transmission. We compared plasma viral load (pVL) rebound after stopping ART initiated in primary (PHI) and chronic HIV infection (CHI ...
Elizabeth Hamlyn +12 more
doaj +2 more sources
Viral rebound and clinical outcomes in hospitalized patients with COVID-19
International Journal of Infectious DiseasesObjectives: Viral rebound has emerged as a virologic characteristic. The study aimed to explore its determinants and impact on clinical outcomes. Methods: The study included adults hospitalized for COVID-19 at a tertiary hospital in Taiwan from January ...
Tzu-Ping Weng +5 more
doaj +2 more sources
Vesicular MicroRNA as Potential Biomarkers of Viral Rebound. [PDF]
Cells, 2022 Changes in the cellular microRNA (miRNA) expression profile in response to HIV infection, replication or latency have been reported. Nevertheless, little is known concerning the abundance of miRNA in extracellular vesicles (EVs). In the search for a reliable predictor of viral rebound, we quantified the amount of miR-29a, miR-146a, and miR-155 in two ...
Bazié WW +6 more
europepmc +5 more sources
An investigation of the possible extent of the re-spending rebound effect in the sphere of consumer products [PDF]
, 2002 A key method used to reduce the environmental impact of a product is to make it more energy efficient. Previous studies have found that the potential benefits from improved efficiency are often at least partially negated by increased use of the product.
Billett, EH, Chalkey, A, Harrison, DJ
core +7 more sources
Soluble markers of viral rebound and post-treatment HIV control. [PDF]
Curr Opin HIV AIDSPurpose of review We focus on the different classes of biological molecules measurable in easily accessible bodily fluids that have the potential to serve as biomarkers for the HIV post-treatment controller (PTC) phenotype and/or the timing of viral rebound after stopping antiretroviral therapy (ART).
Giron LB, Pasternak AO, Abdel-Mohsen M.
europepmc +6 more sources
Detecting Sources of Immune Activation and Viral Rebound in HIV Infection. [PDF]
J Virol, 2022 Abstract Antiretroviral therapy (ART) generally suppresses HIV replication to undetectable levels in peripheral blood, but immune activation associated with increased morbidity and mortality is sustained during ART, and infection rebounds when treatment is interrupted.
Wietgrefe SW +20 more
europepmc +3 more sources
Viral Rebound Kinetics Correlate with Distinct HIV Antibody Features. [PDF]
mBio, 2021 Plasma viremia reoccurs in most HIV-infected individuals once antiretroviral therapy is interrupted, and interindividual differences in the kinetics of viral rebound have been associated with virological and immunological factors. Antibody features, including Fc functionality and Fc glycosylation, have been identified as sensitive surrogates for ...
Bartsch YC +13 more
europepmc +6 more sources
Unified model of short- and long-term HIV viral rebound for clinical trial planning [PDF]
Journal of the Royal Society Interface, 2021 Jonathan Z Li +2 more
exaly +2 more sources