Results 31 to 40 of about 38,667 (276)

Immunotherapy with DNA vaccine and live attenuated rubella/SIV gag vectors plus early ART can prevent SIVmac251 viral rebound in acutely infected rhesus macaques.

PLoS ONE, 2020
Anti-retroviral therapy (ART) has been highly successful in controlling HIV replication, reducing viral burden, and preventing both progression to AIDS and viral transmission. Yet, ART alone cannot cure the infection.
Konstantin Virnik, Margherita Rosati, Alexei Medvedev, Aaron Scanlan, Gabrielle Walsh, Frances Dayton, Kate E Broderick, Mark Lewis, Yvonne Bryson, Jeffrey D Lifson, Ruth M Ruprecht, Barbara K Felber, Ira Berkower   +12 more
doaj   +1 more source

Immunological biomarkers predict HIV-1 viral rebound after treatment interruption [PDF]

Nature Communications, 2015
AbstractTreatment of HIV-1 infection with antiretroviral therapy (ART) in the weeks following transmission may induce a state of ‘post-treatment control’ (PTC) in some patients, in whom viraemia remains undetectable when ART is stopped. Explaining PTC could help our understanding of the processes that maintain viral persistence.
Hurst, J, Hoffmann, M, Pace, M, Williams, J, Thornhill, J, Hamlyn, E, Meyerowitz, J, Willberg, C, Willberg, C, Koelsch, K, Robinson, N, Brown, H, Fisher, M, Kinloch, S, Cooper, D, Schechter, M, Tambussi, G, Fidler, S, Babiker, A, Weber, J, Kelleher, A, Phillips, R, Frater, A   +22 more
openaire   +5 more sources

Analytical Treatment Interruption after Short-Term Antiretroviral Therapy in a Postnatally Simian-Human Immunodeficiency Virus-Infected Infant Rhesus Macaque Model

mBio, 2019
To achieve long-term viral remission in human immunodeficiency virus (HIV)-infected children, novel strategies beyond early antiretroviral therapy (ART) will be necessary. Identifying clinical predictors of the time to viral rebound upon ART interruption
Ria Goswami, Ashley N. Nelson, Joshua J. Tu, Maria Dennis, Liqi Feng, Amit Kumar, Jesse Mangold, Riley J. Mangan, Cameron Mattingly, Alan D. Curtis, Veronica Obregon-Perko, Maud Mavigner, Justin Pollara, George M. Shaw, Katharine J. Bar, Ann Chahroudi, Kristina De Paris, Cliburn Chan, Koen K. A. Van Rompay, Sallie R. Permar   +19 more
doaj   +1 more source

Relationship between intact HIV-1 proviruses in circulating CD4+ T cells and rebound viruses emerging during treatment interruption. [PDF]

, 2018
Combination antiretroviral therapy controls but does not cure HIV-1 infection because a small fraction of cells harbor latent viruses that can produce rebound viremia when therapy is interrupted. The circulating latent virus reservoir has been documented
Barton, John, Caskey, Marina, Cohen, Yehuda Z, Cohn, Lillian B, Gruell, Henning, Jankovic, Mila, Klein, Florian, Lorenzi, Julio CC, Lu, Ching-Lan, Mendoza, Pilar, Nogueira, Lilian, Nussenzweig, Michel C, Oliveira, Thiago Y, Pai, Joy A   +13 more
core   +1 more source

Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys [PDF]

Nature, 2018
The latent viral reservoir is the critical barrier for the development of a cure for HIV-1 infection. Previous studies have shown direct antiviral activity of potent HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) administered when antiretroviral therapy (ART) was discontinued, but it remains unclear whether bNAbs can target the viral ...
Borducchi, Erica N., Liu, Jinyan, Nkolola, Joseph P., Cadena, Anthony M., Yu, Wen-Han, Fischinger, Stephanie, Broge, Thomas, Abbink, Peter, Mercado, Noe B., Chandrashekar, Abishek, Jetton, David, Peter, Lauren, McMahan, Katherine, Moseley, Edward T., Bekerman, Elena, Hesselgesser, Joseph, Li, Wenjun, Lewis, Mark G., Alter, Galit, Geleziunas, Romas, Barouch, Dan H.   +20 more
openaire   +2 more sources

Factors associated with viral suppression and rebound among adult HIV patients on treatment: a retrospective study in Ghana

AIDS Research and Therapy, 2022
Background Viral suppression remains the most desired outcome in the management of patients with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) and this can be achieved by an effective Antiretroviral Therapy (ART).
Stephen Opoku, Samuel Asamoah Sakyi, Nana Kwame Ayisi-Boateng, Anthony Kwame Enimil, Ebenezer Senu, Richard Owusu Ansah, Bismark Dankwah Aning, Diana Atsieno Ojuang, Doreen Nafula Wekesa, Fatima Osman Ahmed, Chidinma B. Okeke, Ama Darkoaa Sarfo   +11 more
doaj   +1 more source

Socioeconomic status and treatment outcomes for individuals with HIV on antiretroviral treatment in the UK: cross-sectional and longitudinal analyses [PDF]

, 2016
Background: Few studies have assessed the effect of socioeconomic status on HIV treatment outcomes in settings with universal access to health care. Here we aimed to investigate the association of socioeconomic factors with antiretroviral therapy (ART ...
Apter, Beer, Broadhead, Burch, Chêne, Collazos, Elzi, Girardi, Glass, Goldman, Hawkins, Kalichman, Le Moing, Legarth, Marmot, Moralejo, Nachega, Paterson, Pellowski, Peyrot, Protopopescu, Rosin, Saracino, Saydah, Shacham, Sherr, Simoni, Simoni, Skingsley, Sobrino-Vegas, Speakman, Weiser, Woods, Zaragoza-Macias, Zou   +34 more
core   +6 more sources

Lack of Detectable HIV-1 Molecular Evolution during Suppressive Antiretroviral Therapy [PDF]

, 2014
A better understanding of changes in HIV-1 population genetics with combination antiretroviral therapy (cART) is critical for designing eradication strategies.
Angeline O'Shea, AS Perelson, B Joos, B Shi, C Shiu, Carry Poethke, Catherine Rehm, D McMahon, E Martinez, Elizabeth M. Anderson, F Maldarelli, F Maldarelli, Frank Maldarelli, G Achaz, H Hatano, H Mens, HF Gunthard, IM Rouzine, JB Dinoso, JM Benito, JM Coffin, JM Coffin, JM Cornuet, JM Llibre, John M. Coffin, John W. Mellors, Jonathan Spindler, JR Bailey, JW Cohen Stuart, K Tamura, L Ruiz, M Kearney, M Kearney, MA Martinez, MA Polis, Mary F. Kearney, MJ Buzon, N Llewellyn, Nicholas Kovacs, Q Zhang, RE Nettles, Robert F. Siliciano, RR Hudson, RT Gandhi, S Palmer, S Palmer, SA Yukl, Sloane Yu, T Elbeik, TA Wagner, TP Brennan, TW Chun, TW Chun, Wei Shao   +53 more
core   +11 more sources

Viral load and rebound in children with coronavirus disease 2019 during the first outbreak in Daegu city [PDF]

Clinical and Experimental Pediatrics, 2021
Background Viral load and shedding duration are highly associated with the transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection.
Mi Ae Chu, Yoon Young Jang, Dong Won Lee, Sung Hoon Kim, Namhee Ryoo, Sunggyun Park, Jae Hee Lee, Hai Lee Chung   +7 more
doaj   +1 more source

Predictions of time to HIV viral rebound following ART suspension that incorporate personal biomarkers.

PLoS Computational Biology, 2019
Antiretroviral therapy (ART) effectively controls HIV infection, suppressing HIV viral loads. Suspension of therapy is followed by rebound of viral loads to high, pre-therapy levels.
Jessica M Conway, Alan S Perelson, Jonathan Z Li   +2 more
doaj   +1 more source