Results 61 to 70 of about 606,321 (264)
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Virological and immunological outcome of treatment interruption in HIV-1-infected subjects vaccinated with MVA-B. [PDF]
PLoS ONE, 2017 The most relevant endpoint in therapeutic HIV vaccination is the assessment of time to viral rebound or duration of sustained control of low-level viremia upon cART treatment cessation.
Miriam Rosás-Umbert +16 more
doaj +1 more source
Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier +3 more
wiley +1 more source
CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques
Nature Communications, 2019 Viral rebound following discontinuation of antiretroviral therapy (ART) is a major obstacle for HIV cure. Here, the authors show that adoptive cellular therapy using autologous Env-specific T cells augmented by therapeutic vaccination can control viral ...
Jin Fan +9 more
doaj +1 more source
Increased risk of virologic rebound in patients on antiviral therapy with a detectable HIV load <48 copies/mL. [PDF]
PLoS ONE, 2012 We investigated the independent effects of HIV-1 "target not detected" measurements versus those that were detectable but below the limit of quantification by Taqman RT-PCR assay on subsequent viral rebound as there are conflicting data regarding the ...
Timothy J Henrich +2 more
doaj +1 more source
Negative Rebound and Disinvestment Effects in Response to an Improvement in Energy Efficiency in the UK Economy [PDF]
, 2003 This paper discusses the negative rebound and disinvestment effects arising in response to an improvement in energy efficiency in the UK ...
Turner, Karen
core +4 more sources
Advanced Functional Materials, EarlyView.A geometry‐reconfigured additive manufacturing strategy converts planar printed soft materials into soft compact neural probes with integrated hydrogel electrodes and microfluidic channels. The resulting NeuroMAP platform enables scalable multichannel recording, localized chemical delivery, stable in vivo electrophysiological recording, and reduced ...
Hyunjin Lee +15 more
wiley +1 more source
Advanced Robotics Research, EarlyView.This article introduces a soft wearable eyelid sling device incorporating a hydraulic soft artificial muscle (SAM) for achieving complete closure of an eyelid. The SAM is driven by a cam mechanism that provides a displacement profile closely matched with those of a healthy eyelid.
Patrick Pruscino +7 more
wiley +1 more source
Frontiers in Immunology, 2017 Human immunodeficiency virus (HIV) infects millions of people worldwide, and new cases continue to emerge. Once infected, the virus cannot be cleared by the immune system and causes acquired immunodeficiency syndrome.
Yew Ann Leong +3 more
doaj +1 more source
PLoS ONE, 2021 A therapeutic vaccine that induces lasting control of HIV infection could eliminate the need for lifelong adherence to antiretroviral therapy. This study investigated a therapeutic DNA vaccine delivered with a single adjuvant or a novel combination of ...
Hillary Claire Tunggal +8 more
doaj +1 more source