Results 81 to 90 of about 606,321 (264)

COVID-19 Rebound in Nirmatrelvir Plus Ritonavir Treatment and Control Groups: Prospective Cohort Study

Interactive Journal of Medical Research
BackgroundObservation of COVID-19 rebound after nirmatrelvir plus ritonavir (NPR) has driven important questions surrounding one of the only direct-acting antiviral treatments for COVID-19.
Jacqueline K Kueper, Kalyani Kottilil, Giorgio Quer, Danielle C Chiang, Emily G Spencer, Jyothi Purushotham, Edward Ramos, Leila Roumani, Kristian G Andersen, Eric J Topol, Jay A Pandit, Michael J Mina   +11 more
doaj   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Understanding early HIV-1 rebound dynamics following antiretroviral therapy interruption: The importance of effector cell expansion.

PLoS Pathogens
Most people living with HIV-1 experience rapid viral rebound once antiretroviral therapy is interrupted; however, a small fraction remain in viral remission for an extended duration.
Tin Phan, Jessica M Conway, Nicole Pagane, Jasmine Kreig, Narmada Sambaturu, Sarafa Iyaniwura, Jonathan Z Li, Ruy M Ribeiro, Ruian Ke, Alan S Perelson   +9 more
doaj   +1 more source

Determinants of post-treatment rebound setpoint viral load.

, 2023
We analysed animals from the three cohorts to understand factors associated with the post-rebound setpoint viral level. Viral load at treatment (A) and peak viral load before treatment (B) where poorly predictive of post-rebound setpoint viral load when ...
Christine M. Fennessey (10777108), Gregory Q. Del Prete (10994503), Mirko Paiardini (243070), Steffen S. Docken (3155133), Justin L. Harper (7517858), Mykola Pinkevych (125551), Miles P. Davenport (8201889), Michael R. Betts (11682040), Brandon F. Keele (7450001), Afam A. Okoye (11965448), Maria Pino (109981)   +10 more
core   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Rebound of HBV DNA after cessation of nucleos/tide analogues in chronic hepatitis B patients with undetectable covalently closed

JHEP Reports, 2020
Background & Aims: Nucleos(t)ide analogues (NUCs) effectively suppress serum HBV DNA. Previously, we have identified 21 patients with undetectable covalently closed circular DNA (cccDNA) upon long-term NUC therapy.
Ching-Lung Lai, Danny Ka-Ho Wong, Gerald Tsz-Yau Wong, Wai-Kay Seto, James Fung, Man-Fung Yuen   +5 more
doaj   +1 more source

Energy Elasticities and the Rebound Effect: A Comprehensive Empirical Analysis [PDF]

, 2016
In diesem Forschungsprojekt werden aktuelle Preis- und Einkommenselastizitäten für Energie und andere Produktionsfaktoren bzw. Konsumgütergruppen in der Schweiz geschätzt. Im Weiteren wird der Rebound-Effekt für den privaten Transport untersucht.
Müller, Daniel, Mohler, Lukas, Deininger, Sebastian   +2 more
core  

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Duration of post-rebound viral control to <10,000 copies/ml.

, 2023
In order to compare the duration of post-rebound control, we compared the proportion of each cohort that maintained post-rebound viral loads below 10,000 copies per ml at different times after ATI.
Christine M. Fennessey (10777108), Gregory Q. Del Prete (10994503), Mirko Paiardini (243070), Steffen S. Docken (3155133), Justin L. Harper (7517858), Mykola Pinkevych (125551), Miles P. Davenport (8201889), Michael R. Betts (11682040), Brandon F. Keele (7450001), Afam A. Okoye (11965448), Maria Pino (109981)   +10 more
core   +1 more source