Results 201 to 210 of about 361,433 (303)

ViralMultiNet: A structure-aware multimodal framework for viral protein function prediction in wastewater surveillance. [PDF]

PLoS One
Liu F, Lai T, Xu W, Li G.
europepmc   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Minimal Genome, Maximal Effect: How Polyomavirus Genomes Are Capable of Complex Pathogenesis. [PDF]

Viruses
Lano M, Milavetz B.
europepmc   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

A Systematic Evaluation of Protein Phase Separation Predictors across Diverse Protein Landscapes. [PDF]

Comput Struct Biotechnol J
Gilroy KE, Barr JN.
europepmc   +1 more source

The TTV1-encoded viral protein TPX: primary structure of the gene and the protein

Nucleic Acids Research, 1990
Horst Neumann, Wolfram Zillig
openaire   +3 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Chikungunya virus nsP2: Insights into viral replication, pathogenesis, and therapeutic targeting. [PDF]

Virulence
Xu S, Li K, Tan Q, Yuan L, Huang R, Feng Y, Xu K, Zhu Z, Deng L, Deng Y, Ren Y, Yang J, Yang X.   +12 more
europepmc   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Modulation of Host Innate Immune Response by Highly Pathogenic Human Coronaviruses during Viral Infection. [PDF]

J Microbiol Biotechnol
Kim YJ, Lee SJ, Lee W, Kim SJ, Ahn DG.
europepmc   +1 more source