Results 251 to 260 of about 858,835 (303)

Structural Proteins of Bovine Viral Diarrhea Virus

American Journal of Veterinary Research, 1975
SUMMARY A procedure for the purification of radioactively labeled bovine viral diarrhea virus was critically evaluated. Purification of virus from artificial mixtures of unlabeled infected and labeled noninfected cells indicated that the extent of purification was approximately 100-fold with respect to host proteins.
R F, Pritchett, Y C, Zee
openaire   +2 more sources

NMR Analysis of Viral Protein Structures

2008
Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool to study the three-dimensional structure of proteins and nucleic acids at atomic resolution. Since the NMR data can be recorded in solution, conditions such as pH, salt concentration, and temperature can be adjusted so as to closely mimic the biomacromolecules natural milieu.
Andrew J, Dingley, Inken, Lorenzen, Joachim, Grötzinger   +2 more
openaire   +2 more sources

Structural Mechanism of Viral Tethering by the Anti‐Viral Protein BST‐2

The FASEB Journal, 2017
BST‐2/tetherin is a human extracellular transmembrane protein that serves as a host defense factor against HIV‐1, HIV‐2, SIV, and other viruses by inhibiting viral budding. Structurally, BST‐2 is a homo‐dimeric coiled‐coil that is connected to the host cell membrane by N and C terminal transmembrane anchors.
Kadir Ozcan, Christopher Berndsen
openaire   +1 more source

Biosensor Characterization of Structure–Function Relationships in Viral Proteins

2004
Publisher Summary This chapter discusses the biosensor characterization of structure–function relationships in viral proteins. The most widely used biosensor instrument is the BIACORE. The chapter discusses the mapping of viral epitopes. The regions of the viral proteins recognized by the antibody are usually described in terms of amino-acid residues
Choulier, L., Altschuh, Danièle, Zeder-Lutz, G., van Regenmortel, M.H.V.   +3 more
openaire   +2 more sources

The Atomic Structure of the Virally Encoded Antifungal Protein, KP6

Journal of Molecular Biology, 2013
Killer toxins are produced by several genera of yeast and filamentous fungi. A small proportion of Ustilago maydis strains produce killer toxins, to which they are resistant, but sensitive strains are the majority in the wild populations. There are three killer types (P1, P4 and P6) that secrete KP1, KP4 and KP6 toxins, respectively, which are produced
Aron, Allen, Elizabeth, Chatt, Thomas J, Smith   +2 more
openaire   +2 more sources

Structure based sequence analysis of viral and cellular protein assemblies

Journal of Structural Biology, 2016
It is well accepted that, in general, protein structural similarity is strongly related to the amino acid sequence identity. To analyze in great detail the correlation, distribution and variation levels of conserved residues in the protein structure, we analyzed all available high-resolution structural data of 5245 cellular complex-forming proteins and
Daniel J, Montiel-García, Ranjan V, Mannige, Vijay S, Reddy, Mauricio, Carrillo-Tripp   +3 more
openaire   +2 more sources

Curvature Dependence of Viral Protein Structures on Encapsidated Nanoemulsion Droplets

ACS Nano, 2008
Virus-like particles are biomimetic delivery vehicles that cloak nanoscale cores inside coatings of viral capsid proteins, offering the potential for protecting their contents and targeting them to particular tissues and cells. To date, encapsidation has been demonstrated only for a relatively limited variety of core materials, such as compressible ...
Connie B, Chang, Charles M, Knobler, William M, Gelbart, Thomas G, Mason   +3 more
openaire   +2 more sources

Structure-guided discovery of viral proteins that inhibit host immunity

Cell
Viruses encode proteins that inhibit host defenses, but sifting through the millions of available viral sequences for immune-modulatory proteins has been so far impractical. Here, we develop a process to systematically screen virus-encoded proteins for inhibitors that physically bind host immune proteins.
Erez Yirmiya, Samuel J. Hobbs, Azita Leavitt, Ilya Osterman, Carmel Avraham, Dina Hochhauser, Barak Madhala, Marharyta Skovorodka, Joel M.J. Tan, Hunter C. Toyoda, Igor Chebotar, Maxim Itkin, Sergey Malitsky, Gil Amitai, Philip J. Kranzusch, Rotem Sorek   +15 more
openaire   +2 more sources

SARS-CoV-2 spike protein: structure, viral entry and variants

Nature Reviews Microbiology
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a devastating global pandemic for 4 years and is now an endemic disease. With the emergence of new viral variants, COVID-19 is a continuing threat to public health despite the wide availability of vaccines.
Bing Chen, Michael Farzan, Hyeryun Choe
openaire   +2 more sources