Results 271 to 280 of about 361,433 (303)

Biosensor Characterization of Structure–Function Relationships in Viral Proteins

2004
Publisher Summary This chapter discusses the biosensor characterization of structure–function relationships in viral proteins. The most widely used biosensor instrument is the BIACORE. The chapter discusses the mapping of viral epitopes. The regions of the viral proteins recognized by the antibody are usually described in terms of amino-acid residues
Choulier, L., Altschuh, Danièle, Zeder-Lutz, G., van Regenmortel, M.H.V.   +3 more
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Kinetic Stability and Crystal Structure of the Viral Capsid Protein SHP

Journal of Molecular Biology, 2004
SHP, the capsid-stabilizing protein of lambdoid phage 21, is highly resistant against denaturant-induced unfolding. We demonstrate that this high functional stability of SHP is due to a high kinetic stability with a half-life for unfolding of 25 days at zero denaturant, while the thermodynamic stability is not unusually high.
Forrer P, Chang C, Ott D, Wlodawer A, Plückthun A   +4 more
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Modification of viral structural proteins of herpesvirus sylvilagus by glycosylation and phosphorylation

Journal of Virology, 1984
The structural proteins of herpesvirus sylvilagus, a lymphotropic gamma herpesvirus, were analyzed by sodium dodecyl sulfate and two-dimensional polyacrylamide gel electrophoreses. Modification of the proteins by glycosylation and phosphorylation was shown by the incorporation of [14C]glucosamine or 32Pi into material which comigrated with [35S ...
H, Rouhandeh, R, Cohrs
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Structural characterization of viral envelope proteins

2022
Infection by viruses having lipid bilayer envelopes proceeds through the fusion of the viral envelope with a membrane of the host cell. This reaction is catalyzed by viral envelope proteins, which are exposed on the virus surface. Viral envelope proteins are responsible for the two major steps in virus entry: 1)attachment to cellular receptor/s and 2 ...
openaire   +1 more source

Structure based sequence analysis of viral and cellular protein assemblies

Journal of Structural Biology, 2016
It is well accepted that, in general, protein structural similarity is strongly related to the amino acid sequence identity. To analyze in great detail the correlation, distribution and variation levels of conserved residues in the protein structure, we analyzed all available high-resolution structural data of 5245 cellular complex-forming proteins and
Daniel J, Montiel-García, Ranjan V, Mannige, Vijay S, Reddy, Mauricio, Carrillo-Tripp   +3 more
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Structure-guided discovery of viral proteins that inhibit host immunity

Cell
Viruses encode proteins that inhibit host defenses, but sifting through the millions of available viral sequences for immune-modulatory proteins has been so far impractical. Here, we develop a process to systematically screen virus-encoded proteins for inhibitors that physically bind host immune proteins.
Erez Yirmiya, Samuel J. Hobbs, Azita Leavitt, Ilya Osterman, Carmel Avraham, Dina Hochhauser, Barak Madhala, Marharyta Skovorodka, Joel M.J. Tan, Hunter C. Toyoda, Igor Chebotar, Maxim Itkin, Sergey Malitsky, Gil Amitai, Philip J. Kranzusch, Rotem Sorek   +15 more
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Enzyme regions in structural and viral proteins.

Protein sequences & data analysis, 1989
Enzyme sequences similar to structural and viral sequences are presented. Evolutionary and functional relationships are implicated from these findings.
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Functional analysis of viral nonstructural and structural proteins

1989
The genera Alphavirus and Flavivirus contain enveloped RNA viruses which are similar in size, morphology, and RNA content, and were once considered to belong to the same family, the Togaviridae. Recently the flaviviruses were reclassified as a separate family, the Flaviviridae, because they differ markedly from alphaviruses in replication strategy and ...
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Structural comparison of three viral “fusion” proteins

Biochemical Society Transactions, 1991
B H, Nicholson, M, Naase
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Structural Folds of Viral Proteins

2003
Michael S, Chapman, Lars, Liljas
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