Results 271 to 280 of about 540,107 (353)

Accumulation of mutations in nsp4, E, and the S2 subunit underlies mammalian cell tropism expansion and virulence attenuation of avian coronavirus. [PDF]

PLoS Pathog
Li Y, Zhang X, Liang R, Li R, Yang R, Zhang L, Zhao Y, Zhang G, Zhao J.   +8 more
europepmc   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Rewriting the viral script: post-translational modifications orchestrating SARS-CoV-2 pathogenesis and immune evasion. [PDF]

Front Microbiol
Qu J, Liu M, Zhou C.
europepmc   +1 more source

A Transmissible Gastroenteritis Coronavirus Nucleoprotein Epitope Elicits T Helper Cells That Collaborate in the in Vitro Antibody Synthesis to the Three Major Structural Viral Proteins

, 1995
Inés M. Antón, Carlos Suñé, Rob H. Meloen, Francisco Borrás‐Cuesta, Luis Enjuanes   +4 more
openalex   +2 more sources

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Respiratory enterovirus D68: virology, clinical surveillance, host-pathogen interactions, and therapeutic prospects. [PDF]

Front Cell Infect Microbiol
Gui Y, Han B, Wei J, Sun D, Zhou L, Yuan S, Xie W, Feng H.   +7 more
europepmc   +1 more source

The Unique Stacked Rings in the Nucleocapsid of the White Spot Syndrome Virus Virion Are Formed by the Major Structural Protein VP664, the Largest Viral Structural Protein Ever Found

, 2004
Jiann‐Horng Leu, Jyh-Ming Tsai, Han‐Ching Wang, Andrew H.-J. Wang, Chung‐Hsiung Wang, Guang‐Hsiung Kou, Chu‐Fang Lo   +6 more
openalex   +2 more sources

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

Signal peptidase complex mediates rotavirus VP7 processing and virion assembly. [PDF]

PLoS Pathog
Zhu X, Li E, Sanchez-Tacuba L, Beatty W, Li B, Ding S.   +5 more
europepmc   +1 more source

Structural modeling reveals viral proteins that manipulate host immune signaling [PDF]

Nitzan Tal, Romi Hadari, Renee B. Chang, Ilya А. Osterman, R.L. Jacobson, Erez Yirmiya, Nathalie Béchon, Dina Hochhauser, Mercedes Rivera, Barak Madhala, Jeremy Garb, Tanita Wein, Philip J. Kranzusch, Gil Amitai, Rotem Sorek   +14 more
openalex   +1 more source