Results 101 to 110 of about 1,666,541 (346)

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Nature, 2018
Individuals infected with HIV-1 require lifelong antiretroviral therapy, because interruption of treatment leads to rapid rebound viraemia. Here we report on a phase 1b clinical trial in which a combination of 3BNC117 and 10-1074, two potent monoclonal ...
Pilar Mendoza, H. Gruell, Lilian Nogueira, J. Pai, Allison L. Butler, Katrina G. Millard, C. Lehmann, I. Suárez, Thiago Y. Oliveira, J. C. Lorenzi, Yehuda Z. Cohen, C. Wyen, T. Kümmerle, Theodora Karagounis, Ching-Lan Lu, L. Handl, Cecilia Unson-O’Brien, R. Patel, Carola Ruping, M. Schlotz, M. Witmer-Pack, I. Shimeliovich, G. Kremer, E. Thomas, K. Seaton, Jill Horowitz, A. West, P. Bjorkman, G. Tomaras, R. Gulick, N. Pfeifer, G. Fätkenheuer, M. Seaman, F. Klein, M. Caskey, M. Nussenzweig   +35 more
semanticscholar   +1 more source

HIV testing, care and viral suppression among men who have sex with men and transgender individuals in Johannesburg, South Africa

PLoS ONE, 2020
Introduction Men who have sex with men and transgender individuals (MSM/TG) carry a disproportionately high burden of HIV, including in South Africa. However, there are few empirical population-representative estimates of viral suppression and the HIV ...
E. Fearon, Siyanda Tenza, Cecilia Mokoena, Kerushini Moodley, A. Smith, A. Bourne, P. Weatherburn, T. Palanee-Phillips   +7 more
semanticscholar   +1 more source

Beyond Viral Suppression [PDF]

Open Forum Infectious Diseases, 2021
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Socioeconomic determinants of suboptimal adherence to ART and elevated HIV viral load in twelve Sub-Saharan African countries: evidence from population HIV impact assessment survey data

Discover Public Health
Background This study identifies factors influencing viral load suppression among HIV-positive individuals in twelve sub-Saharan African (SSA) countries.
Boniface Simpoli Yohana, John Massito, Arbogast Moshi   +2 more
doaj   +1 more source

Adherence clubs and decentralized medication delivery to support patient retention and sustained viral suppression in care: Results from a cluster-randomized evaluation of differentiated ART delivery models in South Africa

PLoS Medicine, 2019
Background Differentiated antiretroviral therapy (ART) delivery models, in which patients are provided with care relevant to their current status (e.g., newly initiating, stable on treatment, or unstable on treatment) has become an essential part of ...
M. Fox, S. Pascoe, A. Huber, J. Murphy, Mokgadi Phokojoe, M. Gorgens, S. Rosen, D. Wilson, Y. Pillay, N. Fraser-Hurt   +9 more
semanticscholar   +1 more source

Therapy of Hepatitis B — Viral Suppression or Eradication? [PDF]

Hepatology, 2006
The practicing clinician is currently faced with a number of treatment options for chronic hepatitis B. Beginning in 1998 with the licensing of lamivudine and subsequently adefovir, the treatment paradigm shifted from 4 to 6 months of conventional alfa interferon to a year of nucleoside analog
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Changing how the third 95 is counted: suitable indicators for measuring U = U with findings from Taiwan

AIDS Research and Therapy
Introduction The World Health Organisation has implemented multiple HIV prevention policies and strived to achieve the 90-90-90 goal by 2020, achieving the 95-95-95 goal by 2030, which refers to 95% of patients living with HIV knowing their HIV status ...
Hsun-Yin Huang, Yu-Ching Huang, Hsiu-Yun Lo, Pei-Chun Chan, Chia-Chi Lee   +4 more
doaj   +1 more source