Results 101 to 110 of about 1,274,523 (300)

Antiretroviral therapy regimens associated with viral suppression in adolescents on HIV treatment in Kenya

HIV & AIDS Review. International Journal of HIV-Related Problems
Introduction According to 2021 UNAIDS report, there were approximately 99,159 adolescents living with human immunodeficiency virus (HIV) in Kenya, with a viral suppression rate of 67%.
Vickie C. Koske, Shiphrah N. Kuria, Edward O. Okonjo, Moses O. Otieno   +3 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Modelling correlates of adolescent and young people viral suppression pathway in Zambia: a Bayesian multi-state approach

Critical Public Health
This study aimed to look into the correlates of viral suppression in HIV-infected adolescents by utilizing Markov renewal multi-state survival models based on the Bayesian Approach, which use a deterministic posterior approximation.
Isaac Fwemba, Samuel Iddi, Yawson Alfred, Chris Guure, Jacques Tamuzi, Peter S. Nyasulu, Samuel Bosomprah   +6 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Early outcomes of South African children with persistent viral non-suppression following switch to dolutegravir-based antiretroviral therapy

Southern African Journal of HIV Medicine
Background: Since 2019 dolutegravir-based antiretroviral therapy (ART) has been introduced for South African children and adolescents living with HIV (CALHIV), including those with persistent viral non-suppression.
Mila Guerrini, Minette Maré, Claire Hulsman, Leonore Greybe, Juanita Lishman, Clair Edson, Thania Hisham, Lisa Frigati, Helena Rabie   +8 more
doaj   +1 more source

Effectiveness of antiretroviral therapy in the single-tablet regimen era

Revista de Saúde Pública, 2018
OBJECTIVE To evaluate the effectiveness of antiretroviral therapy and the associated factors according to the type of regimen used: Single Tablet Regimen or Multiple Tablet Regimen.
Juliana de Oliveira Costa, Maria das Graças Braga Ceccato, Micheline Rosa Silveira, Palmira de Fátima Bonolo, Edna Afonso Reis, Francisco de Assis Acurcio   +5 more
doaj   +1 more source

Viral Suppression and Its Associated Factors in HIV Patients on Highly Active Antiretroviral Therapy (HAART): A Retrospective Study in the Ho Municipality, Ghana

AIDS Research and Treatment, 2020
Background. The WHO targets to end HIV/AIDS as a public health problem by 2030. The introduction of the ambitious “90-90-90” strategy to attain this target is expected to be achieved by the year 2020.
Sylvester Yao Lokpo, Patrick Jnr Ofori-Attah, Louis Selassie Ameke, Christian Obirikorang, Verner Ndudiri Orish, Godsway Edem Kpene, Eric Agboli, Gideon Kye-Duodu, John Gameli Deku, Benedict Kwame Awadzi, Mark Noagbe, Seyram Tetteh Quarshie   +11 more
doaj   +1 more source

Reply: Beyond Viral Suppression

Open Forum Infectious Diseases, 2021
Christoph D Spinner, Eva Wolf, Christoph Boesecke   +2 more
openaire   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Treatment interruption and variation in tablet taking behaviour result in viral failure: a case-control study from Cape Town, South Africa. [PDF]

, 2011
BACKGROUND: Understanding of the impact of non-structured treatment interruption (TI) and variation in tablet-taking on failure of first-line antiretroviral therapy (ART) is limited in a resource-poor setting.
Orrell, Catherine, Lisa-Noelle Ncaca, Katharina Kranzer, Ncaca Lisa-Noelle, Orrell Catherine, Kranzer, Katharina, Ncaca, Lisa-Noelle, Catherine Orrell, Kranzer Katharina   +8 more
core   +1 more source